Nanotechnology Reviews,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 1, 2024
Abstract
Immunotherapy
is
currently
the
main
treatment
for
malignant
tumors
by
activating
immune
cell.
Metabolic
reprogramming
in
tumor
microenvironment
can
greatly
affect
function
of
cell,
and
T
cell
anti-tumor
effector
Therefore,
cell-based
immunometabolic
therapy
improve
clinical
efficacy.
In
therapy,
regular
agents
conventional
forms
are
difficult
to
achieve
intended
efficacy
due
poor
permeability
low
cellular
uptake.
Nanoparticle-based
strategy
serve
as
optimal
targeted
drug
delivery
system
co-encapsulation
multiple
therapeutic
stable
loading.
Here,
we
intend
summarize
examples
nanoparticles
provide
a
comprehensive
helpful
review
covering
notable
vital
applications
nanotechnology-based
strategies
therapy.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 29, 2024
Amino
acid
metabolism
plays
a
pivotal
role
in
tumor
microenvironment,
influencing
various
aspects
of
cancer
progression.
The
metabolic
reprogramming
amino
acids
cells
is
intricately
linked
to
protein
synthesis,
nucleotide
modulation
signaling
pathways,
regulation
cell
metabolism,
maintenance
oxidative
stress
homeostasis,
and
epigenetic
modifications.
Furthermore,
the
dysregulation
also
impacts
microenvironment
immunity.
can
act
as
molecules
that
modulate
immune
function
tolerance
within
reshaping
anti-tumor
response
promoting
evasion
by
cells.
Moreover,
influence
behavior
stromal
cells,
such
cancer-associated
fibroblasts,
regulate
ECM
remodeling
promote
angiogenesis,
thereby
facilitating
growth
metastasis.
Understanding
intricate
interplay
between
crucial
significance.
Expanding
our
knowledge
multifaceted
roles
holds
significant
promise
for
development
more
effective
therapies
aimed
at
disrupting
dependencies
modulating
enhance
responses
inhibit
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(23)
Published: Feb. 15, 2024
Abstract
High‐performance
theranostic
systems
are
of
paramount
importance
for
achieving
precise
image‐guided
cancer
immunotherapy.
Here,
a
novel
nanoplatform
is
presented
that
integrates
aggregation‐induced
emission
luminogen
(AIEgen)
with
prussian
blue
(PB)
nanocatalyzer
robust
The
AIEgen
dimethylamine
substitution
demonstrates
compelling
near‐infrared
(NIR)
light‐induced
photothermal
conversion
and
photodynamic
therapy
(PDT)
capabilities.
By
incorporating
into
porous
PBNPs,
further
enveloped
within
M1
macrophage
membrane,
tumor‐specific
nanoagent
constructed.
This
strategic
integration
effectively
constrains
the
molecular
motion
AIEgen,
leading
to
amplified
NIR‐II
fluorescence
brightness
PDT
attributes.
Moreover,
PBNPs
can
catalyze
tumor‐overexpressed
H
2
O
generate
oxygen
boost
efficacy,
PB's
NIR
absorption
also
intensifies
photoacoustic
imaging
effect.
provides
comprehensive
information
photoimmunotherapy
in
orthotopic
breast
cancer‐bearing
mice.
Leveraging
its
potent
immunogenic
cell
death
effect,
not
only
significantly
inhibits
growth,
but
generates
whole‐cell
therapeutic
vaccine
protect
mice
from
tumor
rechallenge.
In
highly
malignant
post‐surgery
models,
enables
both
accurate
identification
residual
tumors
efficient
inhibition
postoperative
recurrence
pulmonary
metastasis.
study
will
offer
valuable
insights
creating
efficacious
multifaceted
protocols.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4717 - 4737
Published: July 27, 2024
Over
the
past
decade,
research
has
increasingly
identified
unique
dysregulations
in
lipid
metabolism
within
tumor
microenvironment
(TME).
Lipids,
diverse
biomolecules,
not
only
constitute
biological
membranes
but
also
function
as
signaling
molecules
and
energy
sources.
Enhanced
synthesis
or
uptake
of
lipids
TME
significantly
promotes
tumorigenesis
proliferation.
Moreover,
secreted
into
influence
tumor-resident
immune
cells
(TRICs),
thereby
aiding
survival
against
chemotherapy
immunotherapy.
This
review
aims
to
highlight
recent
advancements
understanding
both
TRICs,
with
a
particular
emphasis
on
exogenous
endogenous
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: May 7, 2024
Abstract
Metal
complexes
have
recently
attracted
a
lot
of
attention,
particularly
as
anticancer
and
antibacterial
agents,
owing
to
their
versatile
mechanisms
easily
tunable
characteristics.
However,
the
application
such
compounds
in
medical
context,
especially
cancer
treatment,
has
been
hampered
due
limited
solubility
stability
water
aqueous
solutions,
well
lack
selectivity.
To
address
these
limitations,
several
approaches
developed
improve
targeted
delivery
solubility.
The
first
strategy
involves
physical
encapsulation
metal
within
carriers
facilitate
controlled
drug
release.
second
covalently
linking
polymers,
creating
prodrugs
that
can
be
converted
active
drugs
at
more
controllable
rate.
Despite
increasing
variety
polymers
available,
need
develop
those
able
metabolized
by
body,
producing
non‐toxic
residues,
remains
crucial
for
effective
area
diseases
cancer.
In
this
perspective
article,
an
overview
recent
developments
using
biodegradable
therapy
is
provided.
It
specifically
highlighting
how
formed
nanoparticles
(NPs)
enhance
selectivity
toxicity
toward
cells
compared
parent
complex,
while
simultaneously
reducing
harmful
side
effects
traditional
chemotherapies,
opening
door
them
combination
therapies
(PDT,
PTT).
Small,
Journal Year:
2024,
Volume and Issue:
20(47)
Published: Aug. 16, 2024
Triple-negative
breast
cancer
(TNBC)
responds
poorly
to
immunotherapy
due
insufficient
immunogenicity
and
highly
immunosuppressive
tumor
microenvironment
(TME).
Herein,
an
intelligent
calcium/cobalt-based
nanomodulator
(Ca,Co)CO
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(39), P. 26784 - 26798
Published: Sept. 20, 2024
Accurate
imaging
and
precise
treatment
are
critical
to
controlling
the
progression
of
pancreatic
cancer.
However,
current
approaches
for
cancer
theranostics
suffer
from
limitations
in
tumor
specificity
invasive
surgery.
Herein,
a
cancer-specific
phototheranostic
modulator
(AuHQ)
dominated
by
aggregation-induced
emission
(AIE)
luminogens-tethered
gold
nanoparticles
is
meticulously
designed
facilitate
prominent
fluorescence-photoacoustic
bimodal
imaging-guided
photothermal
immunotherapy.
Once
reaching
microenvironment
(TME),
peptide
Ala-Gly-Phe-Ser-Leu-Pro-Ala-Gly-Cys
(AGFSLPAGC)
linkage
within
AuHQ
can
be
specifically
cleaved
overexpressed
enzyme
Cathepsin
E
(CTSE),
triggering
dual
self-assembly
AuNPs
AIE
luminogens.
The
aggregation
mediated
enzymatic
cleavage
results
potentiated
therapy
(PTT)
under
near-infrared
(NIR)
laser
irradiation,
induced
immunogenic
cell
death
(ICD),
enhanced
photoacoustic
imaging.
Simultaneously,
luminogen
aggregates
formed
hydrophobic
interaction
generate
fluorescence,
enabling
real-time
specific
fluorescence
Furthermore,
coadministration
an
indoleamine
2,3-dioxygenase
1
(IDO1)
inhibitor
with
address
PTT
efficacy
imposed
immunosuppressive
TME
leverage
synergistic
potential
activate
systemic
antitumor
immunity.
Thus,
this
well-designed
facilitates
intelligent
therapeutic
agents,
providing
efficient
approach
theranostics.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
Higher
and
richer
nutrient
requirements
are
typical
features
that
distinguish
tumor
cells
from
AU:
cells,
ensuring
adequate
substrates
energy
sources
for
cell
proliferation
migration.
Therefore,
deprivation
strategies
based
on
targeted
technologies
can
induce
impaired
viability
in
which
more
sensitive
than
normal
cells.
In
this
review,
nutrients
required
by
related
metabolic
pathways
introduced,
anti-tumor
developed
to
target
described.
addition
the
nutritional
characteristics
of
other
microenvironment
(including
macrophages,
neutrophils,
natural
killer
T
cancer-associated
fibroblasts)
new
also
summarized.
conclusion,
recent
advances
targeting
blockade
reviewed,
challenges
prospects
these
discussed,
theoretical
significance
optimizing
clinical
application
nutrition
strategies.
