Cellular Signalling, Journal Year: 2024, Volume and Issue: 126, P. 111529 - 111529
Published: Nov. 28, 2024
Language: Английский
Advanced Science, Journal Year: 2024, Volume and Issue: 11(44)
Published: Oct. 8, 2024
Abstract RNA‐modifying proteins, classified as “writers,” “erasers,” and “readers,” dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing stability, functionality, interactions. To date, over 170 distinct modifications more than 100 enzymes have been identified, with ongoing research expanding these numbers. Although significant progress has made in understanding modification, the regulatory mechanisms that govern proteins themselves remain insufficiently explored. Post‐translational (PTMs) such phosphorylation, ubiquitination, acetylation are crucial modulating function behavior of proteins. However, full extent PTM influence on their role disease development remains to be fully elucidated. This review addresses gaps offering a comprehensive analysis roles PTMs play regulating Mechanistic insights provided into how alter biological processes, contribute cellular function, drive progression. In addition, current landscape is examined, highlighting therapeutic potential targeting for precision medicine. By advancing networks, this seeks facilitate effective strategies inspire future critical area
Language: Английский
Citations
4
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(10)
Published: March 4, 2025
Viruses have evolved unique strategies to circumvent host control of protein synthesis and enable viral in the face response. Defining factors that regulate messenger RNA (mRNA) translation is thus critical understand how viruses replicate cause disease. To identify might mRNA translation, we developed a technique for identifying proteins associated with native expressed from its endogenous promoter genomic locus. This approach uses guide target dCas13b fused biotin ligase domain specific RNA, where it covalently labels close proximity. Using this approach, identified multiple transcripts encoding human cytomegalovirus (HCMV) IE1 IE2 found several positively or negatively HCMV replication. We confirmed one such protein, cellular Y-box binding 1 (YBX1), binds immediate early mRNAs required efficient expression virus Ablating YBX1 reduced association polysomes, demonstrating role as positive regulator translation. These results provide powerful tool unraveling RNA–protein interactions can be used wide range biological processes reveal gene expression.
Language: Английский
Citations
0
Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2373 - 2373
Published: Nov. 20, 2024
RNA modification is a key posttranscriptional process playing various biological roles, and one which has been reported to exist extensively in cellular RNAs. Interestingly, recent studies have shown that viral RNAs also contain variety of modifications, are regulated dynamically by host machinery play critical roles different stages the life cycle. In this review, we summarize reports four typical modifications on RNAs, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N4-acetylcytosine (ac4C), N1-methyladenosine (m1A), describe molecular mechanisms these processes, illustrate their impacts replication, pathogenicity, innate immune responses. Notably, find viruses share some common features generation, regulation, function, highlighting potential for related serve as targets or bases development antiviral therapeutics vaccines.
Language: Английский
Citations
2
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 189223 - 189223
Published: Nov. 1, 2024
Language: Английский
Citations
0
Cellular Signalling, Journal Year: 2024, Volume and Issue: 126, P. 111529 - 111529
Published: Nov. 28, 2024
Language: Английский
Citations
0