A whole-brain connectivity map of mouse insular cortex

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Sept. 17, 2020

The insular cortex (IC) plays key roles in emotional and regulatory brain functions is affected across psychiatric diseases. However, the brain-wide connections of mouse IC have not been comprehensively mapped. Here, we traced whole-brain inputs outputs its rostro-caudal extent. We employed cell-type-specific monosynaptic rabies virus tracings to characterize afferent onto either excitatory or inhibitory neurons, adeno-associated viral label efferent axons. While connectivity between other cortical regions was highly bidirectional, with subcortical structures often unidirectional, revealing prominent cortical-to-subcortical subcortical-to-cortical pathways. posterior medial exhibited resembling patterns, while anterior distinct, suggesting two major functional compartments. Our results provide insights into anatomical architecture thus a structural basis guide investigations complex functions.

Language: Английский

---

A Motivational and Neuropeptidergic Hub: Anatomical and Functional Diversity within the Nucleus Accumbens Shell

Neuron, Journal Year: 2019, Volume and Issue: 102(3), P. 529 - 552

Published: May 1, 2019

Language: Английский

---

Striatal Local Circuitry: A New Framework for Lateral Inhibition

Neuron, Journal Year: 2017, Volume and Issue: 96(2), P. 267 - 284

Published: Oct. 1, 2017

Language: Английский

---

Spatial and temporal scales of dopamine transmission

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(6), P. 345 - 358

Published: April 9, 2021

Language: Английский

---

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

Neuron, Journal Year: 2020, Volume and Issue: 107(5), P. 891 - 908.e8

Published: July 17, 2020

Language: Английский

---

Decoding molecular and cellular heterogeneity of mouse nucleus accumbens

Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(12), P. 1757 - 1771

Published: Oct. 18, 2021

Language: Английский

---

Persistent enhancement of basolateral amygdala-dorsomedial striatum synapses causes compulsive-like behaviors in mice

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 8, 2024

Abstract Compulsive behaviors are observed in a range of psychiatric disorders, however the neural substrates underlying not clearly defined. Here we show that basolateral amygdala-dorsomedial striatum (BLA-DMS) circuit activation leads to manifestation compulsive-like behaviors. We revealed BLA neurons projecting DMS, mainly onto dopamine D1 receptor-expressing neurons, largely overlap with neuronal population responds aversive predator stress, widely used anxiogenic stressor. Specific optogenetic BLA-DMS induced strong anxiety response followed by compulsive grooming. Furthermore, developed mouse model for compulsivity displaying wide spectrum chronically activating circuit. In these mice, persistent molecular changes at synapses were causally related phenotypes. Together, our study demonstrates involvement emergence enduring via its synaptic changes.

Language: Английский

---

A Spatiomolecular Map of the Striatum

Cell Reports, Journal Year: 2019, Volume and Issue: 29(13), P. 4320 - 4333.e5

Published: Dec. 1, 2019

The striatum is organized into two major outputs formed by striatal projection neuron (SPN) subtypes with distinct molecular identities. In addition, histochemical division patch and matrix compartments represents an additional spatial organization, proposed to mirror a motor-motivation regionalization. To map the diversity of versus SPNs, we genetically labeled mu opioid receptor (Oprm1) expressing neurons performed single-nucleus RNA sequencing. This allowed us establish definitions patch, matrix, exopatch as well identification Col11a1+ striatonigral SPNs. At tissue level, mapping expression candidate markers reveals organization domains, which are conserved in non-human primate brain. cell-type independent instead represent code found across all SPNs within domain. spatiomolecular establishes formal system for targeting studying subregions subtypes, beyond classical striatopallidal division.

Language: Английский

---

Nucleus Accumbens Modulation in Reward and Aversion

Cold Spring Harbor Symposia on Quantitative Biology, Journal Year: 2018, Volume and Issue: 83, P. 119 - 129

Published: Jan. 1, 2018

The nucleus accumbens (NAc) is a key node of the brain's circuitry that responsible for translating motivation into action. It has been implicated in playing critical roles virtually all forms adaptive and pathological motivated behaviors. subject to modulation by broad array inputs influence NAc activity complex ways are still poorly understood. Here, we briefly review current knowledge about behavioral consequences modulation, focusing on recent studies use novel techniques developed implemented over last decade.

Language: Английский

---

Cholinergic modulation of striatal microcircuits

European Journal of Neuroscience, Journal Year: 2018, Volume and Issue: 49(5), P. 604 - 622

Published: May 24, 2018

The purpose of this review is to bridge the gap between earlier literature on striatal cholinergic interneurons and mechanisms microcircuit interaction demonstrated with use newly available tools. It well known that main source high level acetylcholine in striatum, compared other brain regions, interneurons. These provide an extensive local innervation suggests they may be a key modulator microcircuits. Supporting idea requires consideration functional properties these interneurons, their influence medium spiny neurons, interactions synaptic regulators. Here, we underline effects intrastriatal extrastriatal afferents onto discuss activation pre- postsynaptic muscarinic nicotinic receptors participate modulation neuronal interactions. We further address recent findings about corelease transmitters actions striosome matrix compartments. In addition, summarize evidence acetylcholine-mediated plasticity propose roles for normal physiology. A short examination role neurological disorders such as Parkinson's, Huntington's, Tourette's pathologies dystonia also included.

Language: Английский

---