Nonradical
Fenton-like
catalysis
offers
an
opportunity
to
degrade
extracellular
antibiotic
resistance
genes
(eARGs).
However,
high-loading
single-atom
catalysts
(SACs)
with
controllable
configurations
are
urgently
required
selectively
generate
high-yield
nonradicals.
Herein,
we
constructed
Fe
SACs
(5.4-34.2
wt
%)
uniform
Fe-N4
sites
via
optimized
coordination
balance
of
supermolecular
assembly
for
peroxymonosulfate
activation.
The
selectivity
singlet
oxygen
(1O2)
generation
and
its
contribution
eARGs
degradation
were
both
>98%.
This
targeting
strategy
oxidizing
guanines
low
ionization
potentials
by
1O2
allowed
7
log
within
10
min
eliminated
their
transformation
2
min,
outperforming
most
reported
advanced
oxidation
processes.
Relevant
interactions
between
revealed
at
a
single-molecule
resolution.
exhibited
excellent
universality
stability
different
water
matrices.
These
findings
provide
promising
route
constructing
efficient
selective
treatment.
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(6), P. 565 - 565
Published: June 17, 2024
The
understanding
of
antibiotic
resistance,
one
the
major
health
threats
our
time,
is
mostly
based
on
dated
and
incomplete
notions,
especially
in
clinical
contexts.
“canonical”
mechanisms
action
pharmacodynamics
antibiotics,
as
well
methods
used
to
assess
their
activity
upon
bacteria,
have
not
changed
decades;
same
applies
definition,
acquisition,
selective
pressures,
drivers
resistance.
As
a
consequence,
strategies
improve
usage
overcome
resistance
ultimately
failed.
This
review
gathers
most
“non-canonical”
notions
antibiotics
resistance:
from
alternative
limitations
susceptibility
testing
wide
variety
lateral
gene
transfer
mechanisms,
ubiquity,
societal
factors
maintaining
Only
by
having
“big
picture”
view
problem
can
adequate
harness
be
devised.
These
must
global,
addressing
many
aspects
that
drive
increasing
prevalence
resistant
bacteria
aside
use
antibiotics.
