Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: May 14, 2025

Extracellular vesicles (EVs), a diverse population of bilayer lipid-membrane secreted by cells, have emerged as ideal drug carriers due to their efficient cellular uptake and targeted delivery capabilities. Advancements in medical bioengineering collaborations enabled EVs be engineered for specific marker expression or therapeutic cargo transport, positioning them promising modality treating cancer, neurological disorders, cardiovascular diseases, beyond. EV-based strategies offer distinct advantages, including facilitation intercellular communication immune modulation, high biocompatibility stability, the ability traverse blood-brain barrier, potential synergistic interactions with encapsulated therapeutics enhance efficacy. This review explores EV isolation scalable production, emphasizing cost-effective reproducible manufacturing strategies, cargo-loading methodologies, applications. Additionally, current landscape delivery, clinical translation prospects, prevailing challenges are examined provide comprehensive perspective on systems.

Language: Английский

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium Falciparum

ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

The limited understanding of the mechanism action (MoA) several antimalarials and rise drug resistance toward existing malaria therapies emphasizes need for new strategies to uncover molecular target compounds in

Language: Английский