Hydrophilic Poly(meth)acrylates by Controlled Radical Branching Polymerization: Hyperbranching and Fragmentation

Macromolecules, Journal Year: 2024, Volume and Issue: 57(11), P. 5368 - 5379

Published: May 29, 2024

Topology significantly impacts polymer properties and applications. Hyperbranched polymers (HBPs) synthesized via atom transfer radical polymerization (ATRP) using inimers typically exhibit broad molecular weight distributions limited control over branching. Alternatively, copolymerization of inibramers (IB), such as α-chloro/bromo acrylates with vinyl monomers, yields HBPs precise uniform Herein, we described the synthesis hydrophilic HB polyacrylates in water by copolymerizing a water-soluble IB, oligo(ethylene oxide) methyl ether 2-bromoacrylate (OEOBA), various acrylate comonomers. Visible-light-mediated controlled branching (CRBP) dual catalysis eosin Y (EY) copper complexes resulted weights (Mn = 38 000 to 170 000) degrees (2%–24%). Furthermore, optimized conditions enabled successful application OEOBA synthesize linear-hyperbranched block copolymers hyperbranched protein hybrids (HB-PPH), demonstrating its potential advance complex macromolecular architecture under environmentally benign conditions. Copolymerization methacrylate monomer, (OEOMA500), inibramer was accompanied fragmentation β-carbon C–C bond scission subsequent growth chains from fragments. computational studies investigating depending on IB comonomer structure supported experimental observations. This work expands toolkit for CRBP highlights critical influence reaction outcomes.

Language: Английский

---

Polymer–drug and polymer–protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(4)

Published: July 1, 2024

Polymer-drug conjugates and polymer-protein have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by conjugation therapeutic molecules or functional moieties to polymers, enabling range benefits including extended circulation times, targeted delivery, controlled release, decreased immunogenicity. This review delves into recent advancements challenges clinical translations preclinical studies polymer-drug conjugates. The design principles functionalization strategies crucial development these were explored followed structural properties characteristics various polymer carriers. also identifies significant obstacles translation provides insights directions their future development. article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease.

Language: Английский

---

ATRP with ppb Concentrations of Photocatalysts

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(42), P. 28994 - 29005

Published: Oct. 10, 2024

In atom transfer radical polymerization (ATRP), dormant alkyl halides are intermittently activated to form growing radicals in the presence of a Cu

Language: Английский

---

N-substituted 1,8-naphtalene imide-based (macro)initiator for investigation of photochemically induced ATRP process

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113789 - 113789

Published: Feb. 1, 2025

Language: Английский

---

Tailoring polymer architectures to drive molecular sieving in protein-polymer hybrids

Sustainable Chemistry and Pharmacy, Journal Year: 2025, Volume and Issue: 45, P. 101988 - 101988

Published: March 14, 2025

Language: Английский

---

Polymer Conjugation Benefits Proteins Beyond Simply Extended Half-life

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

---

A General Approach to Predict and Tailor the Nanoscale Permeability of Comb‐Shaped Polymer Coatings

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

Abstract Comb‐shaped polymers such as poly(oligoethylene glycol monomethyl ether) methacrylate) (pOEGMA) are used to produce molecular sieving coatings on proteins. The mechanisms and phenomena implicated in the experimentally observed properties have been recently characterized by simulation. These result from an interplay between steric hindrance, microenvironmental effects, modified protein dynamics. Steric particular, is expected vary considerably a function of geometric parameters system (protein size, polymer grafting density, etc.). In this work, size‐selective permeability characteristics comb‐polymer systematically explored across very broad parameter space gain universal predictive view sieving, for application systems with different dimensions. All features data can be understood when three distinct regimes considered: i) no‐interactions, ii) weak‐interactions, iii) strong‐interactions adjacent chains. Primary secondary considerations provided tuning coating adjust size threshold sieving. corresponding qualitative physical pictures quantitative analyses give robust framework understand that will accelerate development future coatings.

Language: Английский

---

Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10386 - 10386

Published: Sept. 26, 2024

Mechanosensing and mechanotransduction pathways between the Extracellular Matrix (ECM) cells form essential crosstalk that regulates cell homeostasis, tissue development, morphology, maintenance, function. Understanding these mechanisms involves creating an appropriate support elicits signals to guide cellular functions. In this context, polymers can serve as ideal molecules for producing biomaterials designed mimic characteristics of ECM, thereby triggering responsive closely resemble those induced by a natural physiological system. The generated specific stimuli depend on different or synthetic origins polymers, chemical composition, assembly structure, physical surface properties biomaterials. This review discusses most widely used their customization develop with tailored properties. It examines how biomaterials-based be harnessed replicate functions biological cells, making them suitable biomedical biotechnological applications.

Language: Английский

---

Riboflavin‐Catalyzed Photoinduced Atom Transfer Radical Polymerization

Macromolecular Chemistry and Physics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 20, 2024

Abstract The photoATRP of methyl acrylate (MA) is investigated using riboflavin (RF) and CuBr 2 /Me 6 TREN as a dual catalyst system under green LED irradiation (λ ≈ 525 nm). Both RF enhanced oxygen tolerance, enabling effective ATRP in the presence residual oxygen. High molar mass polymers (up to M n 129 000 g·mol −1 ) with low dispersity ( Đ ≤ 1.16) are prepared, chain‐end fidelity confirmed through successful chain extension. molecular masses obtained polymer increased linearly conversion showed high initiation efficiency. Mechanistic studies by laser flash photolysis reveal that predominant activator generation mechanism reductive quenching Me (83%, [CuBr ]/[Me TREN] = 1/3 condition), supported polymerization kinetics thermodynamic calculations.

Language: Английский

---

Heterogenous catalysis for oxygen tolerant photoredox atom transfer radical polymerization and small-molecule dehalogenation

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(41), P. 4264 - 4280

Published: Jan. 1, 2024

Heterogeneous photocatalysts (PCs) have garnered attention for their sustainability and cost-effectiveness.

Language: Английский

---