Wearable Ultrasound Devices for Biomedical Applications DOI Creative Commons
Muyao Wang, Jia Lu,

Haicheng Li

et al.

Published: April 4, 2025

ABSTRACT Wearable devices possess excellent flexibility and can conform to irregular surfaces, extensively changing human healthcare fields. Ultrasonic technology, with its extensive penetration depth, nondestructive nature, versatile functionalities, has been widely applied in the diagnosis treatment of various diseases. However, traditional ultrasound are often bulky rigid, significantly limiting their further development biomedical field. flexible combine advantages wearable electronics providing real‐time, continuous, strategies for applications. seamlessly skin or organ substantially enhancing working performance, durability, comfort. Here, we review recent advancements developing applications, including materials, structural design, applications We provide an overview utilized hemodynamics monitoring, deep‐tissue energy transmission, closed‐loop therapy. Finally, discuss existing challenges future trends devices.

Language: Английский

Materials and Structural Designs toward Motion Artifact-Free Bioelectronics DOI
Byeonghak Park,

Chanho Jeong,

Jehyung Ok

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(10), P. 6148 - 6197

Published: May 1, 2024

Bioelectronics encompassing electronic components and circuits for accessing human information play a vital role in real-time continuous monitoring of biophysiological signals electrophysiology, mechanical physiology, electrochemical physiology. However, noise, particularly motion artifacts, poses significant challenge accurately detecting analyzing target signals. While software-based "postprocessing" methods signal filtering techniques have been widely employed, challenges such as distortion, major requirement accurate models classification, power consumption, data delay inevitably persist. This review presents an overview noise reduction strategies bioelectronics, focusing on reducing artifacts improving the signal-to-noise ratio through hardware-based approaches "preprocessing". One main stress-avoiding is elastic energies applied to bioelectronics prevent stress-induced artifacts. Various including strain-compliance, strain-resistance, stress-damping using unique materials structures explored. Future research should optimize structure designs, establish stable processes measurement methods, develop selectively separating processing overlapping noises. Ultimately, these advancements will contribute development more reliable effective healthcare diagnostics.

Language: Английский

Citations

13
Dry ionic conductive elastomers based on polymeric deep eutectic solvents for bioelectronics DOI
Matías L. Picchio, Antonio Dominguez‐Alfaro, Roque J. Minari

et al.

Journal of Materials Chemistry C, Journal Year: 2024, Volume and Issue: 12(30), P. 11265 - 11284

Published: Jan. 1, 2024

This review highlights the recent progress on polymerizable deep eutectic solvents (PDES) and polyDES as liquid-free ionic elastomers in bioelectronics discusses future directions how these functional polymers can expand field.

Language: Английский

Citations

10
Soft Bioelectronics for Heart Monitoring DOI
Hadi Mirzajani, Michaël Kraft

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(9), P. 4328 - 4363

Published: Sept. 6, 2024

Cardiovascular diseases (CVDs) are a predominant global health concern, accounting for over 17.9 million deaths in 2019, representing approximately 32% of all fatalities. In North America and Europe, adults undergo cardiac surgeries annually. Despite the benefits, such pose risks require precise postsurgery monitoring. However, during postdischarge period, where monitoring infrastructures limited, continuous vital signals is hindered. this area, introduction implantable electronics altering medical practices by enabling real-time out-of-hospital physiological biological information postsurgery. The multimodal bioelectronic platforms have capability heart sensing stimulation, both settings. Furthermore, with emergence machine learning algorithms into healthcare devices, next-generation implantables will benefit artificial intelligence (AI) connectivity skin-interfaced to provide more user-specific results. This Review outlines recent advancements bioelectronics their utilization cardiovascular monitoring, highlighting transformative deployment stimulation toward reaching truly personalized compatible Sustainable Development Goal 3.4 WHO 2030 observatory roadmap. also discusses challenges future prospects these devices.

Language: Английский

Citations

9
Self-Healable, Stretchable, and Super-Soft Bottlebrush Polyester Elastomers for Highly Sensitive Flexible Sensors DOI
Xiaohui Yu, Yufei Wang, Mengke Li

et al.

ACS Applied Polymer Materials, Journal Year: 2023, Volume and Issue: 5(4), P. 2750 - 2759

Published: March 21, 2023

While much effort has been devoted to the creation of super-soft elastomers, there is a dearth research aimed at self-healable and renewable elastomers. Herein, self-healing elastomers are developed based on bottlebrush architecture design dynamic associative transesterification. The polymer precursors generated by ring-opening metathesis polymerization (ROMP) norbornene-terminated macromonomer poly(ε-caprolactone-co-l-lactide) (PCLLA) (NB-PCLLA). After introducing alkyne groups onto end PCLLA side chains, polymers cross-linked achieve elastomer networks via UV-induced "click" thiol-yne reaction between terminal dithiothreitol (DTT) additive. resulting materials exhibit shear modulus as low 17 kPa, high stretchability with breaking strains large 315%, efficiency 95.6% an elevated temperature 80 °C. Taking super-softness advantage, flexible sensor devices assembled prepared elastomer, which highly sensitive deformation gauge factor 0.347. This work demonstrates that high-performance biodegradable unique properties conventional linear impossibly possess can be easily constructed molecular using building blocks.

Language: Английский

Citations

22
An Antidehydration Hydrogel Based on Zwitterionic Oligomers for Bioelectronic Interfacing DOI
Ke He, Pingqiang Cai, Shaobo Ji

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 30, 2023

Abstract Hydrogels are ideal interfacing materials for on‐skin healthcare devices, yet their susceptibility to dehydration hinders practical use. While incorporating hygroscopic metal salts can prevent and maintain ionic conductivity, concerns arise regarding toxicity due the passage of small ions through skin barrier. Herein, an antidehydration hydrogel enabled by incorporation zwitterionic oligomers into its network is reported. This exhibits exceptional water retention properties, maintaining ≈88% weight at 40% relative humidity, 25 °C 50 days about 84% after being heated 3 h. Crucially, molecular design embedded prevents penetration epidermis, as evidenced experimental simulation results. The allows stable signal acquisition in electrophysiological monitoring humans plants under low‐humidity conditions. research provides a promising strategy development epidermis‐safe biocompatible interfaces devices.

Language: Английский

Citations

21
Soft Bioelectronics Using Nanomaterials and Nanostructures for Neuroengineering DOI
Min Jeong Kim, Hyun‐Jin Lee, Seonghyeon Nam

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(11), P. 1633 - 1647

Published: May 16, 2024

ConspectusThe identification of neural networks for large areas and the regulation neuronal activity at single-neuron scale have garnered considerable attention in neuroscience. In addition, detecting biochemical molecules electrically, optically, chemically controlling functions are key research issues. However, conventional rigid bulky bioelectronics face challenges applications, including mechanical mismatch, unsatisfactory signal-to-noise ratio, poor integration multifunctional components, thereby degrading sensing modulation performance, long-term stability biocompatibility, diagnosis therapy efficacy. Implantable been developed to be mechanically compatible with brain environment by adopting advanced geometric designs utilizing intrinsically stretchable materials, but such advances not able address all aforementioned challenges.Recently, exploration nanomaterial synthesis nanoscale fabrication strategies has facilitated design unconventional soft properties similar those tissues submicrometer-scale resolution comparable typical neuron sizes. The introduction nanotechnology provided improved spatial resolution, selectivity, single targeting, even multifunctionality. As a result, this state-of-the-art integrated two main types, i.e., synthesized nanomaterials structures. functional can assembled compose bioelectronics, allowing easy customization their functionality meet specific requirements. unique structures implemented could maximize performance terms stimulation. Such nanobioelectronics demonstrated applicability recording over long period intracellular level incorporation multiple functions, as electrical, optical, chemical stimulation functions.In Account, we will discuss technical pathways implementing nanostructures application neuroengineering. We traced historical development from deformable devices conform neuroengineering Recent approaches that introduced into enhanced spatiotemporal endowed various device functions. These nanobioelectronic technologies discussed categories: describe nanomaterial-integrated exhibiting functionalities modalities depending on nanomaterials. Meanwhile, explained superior administration methods. also exemplified applications across modalities, showcasing clinical treatment neurological diseases, tumors, epilepsy, Parkinson's disease. Finally, direction next-generation technologies.

Language: Английский

Citations

7
Self‐Healing Materials for Bioelectronic Devices DOI Creative Commons
Claire Liu, Shana O. Kelley, Zongjie Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 6, 2024

Abstract Though the history of self‐healing materials stretches far back to mid‐20 th century, it is only in recent years where such unique classes have begun find use bioelectronics—itself a burgeoning area research. Inspired by natural ability biological tissue self‐repair, play multifaceted role context soft, wireless bioelectronic systems, that they can not serve as protective outer shell or substrate for internal electronic circuitry—analogous mechanical barrier skin provides human body—but also, and most importantly, act an active sensing safeguard against damage preserve device functionality enhance overall durability. This perspective presents historical overview, general design principles, developments, future outlook devices, which integrates topics many research disciplines—from science chemistry electronics bioengineering—together.

Language: Английский

Citations

6
Recent Progress in Bio‐Integrated Intelligent Sensing System DOI Creative Commons
Mengwei Liu, Yujia Zhang, Tiger H. Tao

et al.

Advanced Intelligent Systems, Journal Year: 2022, Volume and Issue: 4(6)

Published: March 10, 2022

It is incontrovertible that the bioelectronic enabled bio‐integrated system one of most promising technologies in upcoming decades. Driven by great versatility emerging artificial intelligence, machine‐learning‐supported intelligent sensing (BISS) capable achieving data processing and recognition while conducting multimodal human‐centered sensing; such facilitated systems capitalize benefits both bioelectronics supporting algorithm, enabling accurate physiological/somatosensory at cost certain computing resources. Herein, an overview recent progress BISS presented, with emphasis on high‐tech applications innovations combining flexible sensors algorithmic systems. The main can be divided into three categories, including implantable, skin‐mounted, wearable BISS, which have different requirements for materials, fabrication methods, algorithms, respectively. Advances these areas open new avenues employing as future human–machine interfaces personalized healthcare, human enhancement, well other broad applications.

Language: Английский

Citations

21
Recent advances in soft, implantable electronics for dynamic organs DOI
Won Bae Han, Tae‐Min Jang, Beomjune Shin

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 261, P. 116472 - 116472

Published: June 6, 2024

Language: Английский

Citations

4
Recent Advances in Hydrogel‐Based Soft Bioelectronics and its Convergence with Machine Learning DOI

Eun Seo Lee,

Min Young Lee, Dae‐Hyeong Kim

et al.

Advanced Engineering Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 8, 2024

Recent advancements in artificial intelligence (AI) technologies, particularly machine learning (ML) techniques, have opened up a promising frontier the development of intelligent soft bioelectronics, demonstrating unparalleled performance interfacing with human body. Hydrogels, owing to their unique combination biocompatibility, tunable mechanical properties, and high water content, emerged as versatile platform for constructing bioelectronic devices. Functionalized hydrogels, such conductive can efficiently capture biosignals from various target tissues while seamlessly forming conformal reliable interfaces. They also function an intermediary layer between biological bioelectronics diagnosis therapy purposes. Meanwhile, ML has demonstrated its efficacy processing extensive datasets collected bioelectronics. The convergence hydrogel‐based unlocked myriad possibilities unprecedented diagnostics, therapeutics, beyond. In this review, latest advances are introduced. After briefly describing materials device strategies high‐performance hydrogel how be integrated augment functionalities is discussed. examples ML‐integrated then Finally, review concluded by introducing future potential applications AI alongside inherent challenges interdisciplinary domain.

Language: Английский

Citations

4