Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 1, 2024
Abstract
Nanoscale
molecular
materials
have
emerged
as
a
new
class
of
compounds
at
the
nanometer
scale
with
well‐defined
chemical
structures,
remarkable
uniformity
and
high
reproducibility.
Among
these
materials,
zirconium‐based
metal‐organic
cages
(MOCs)
attracted
significant
attention
due
to
their
exceptional
stability
applications
in
catalysis,
recognition
separation
so
on.
However,
poor
water
solubility
impedes
biomedical
applications.
In
this
study,
decorating
ligand
Ru(II)
complexes
can
not
only
improve
but
also
endow
bright
red
fluorescence
large
Stokes
shift
(180
nm).
Notably,
butyl‐modification
cyclopentadiene
rings
significantly
enhance
cell
uptake
(100
folds)
nanocages
via
actin‐
dynamin‐mediated
endocytosis.
The
unique
advantages
easy
modifiability
make
them
highly
promising
candidates
for
diverse
biological
Molecules,
Journal Year:
2024,
Volume and Issue:
29(7), P. 1621 - 1621
Published: April 4, 2024
The
field
of
molecular
cages
has
attracted
increasing
interest
in
relation
to
the
development
biological
applications,
as
evidenced
by
remarkable
examples
published
recent
years.
Two
key
factors
have
contributed
this
achievement:
First,
and
adjustable
host–guest
chemical
properties
make
them
highly
suitable
for
applications.
This
allows
encapsulating
therapeutic
molecules
improve
their
properties.
Second,
significant
advances
been
made
synthetic
methods
create
water-soluble
cages.
Achieving
necessary
water
solubility
is
a
challenge,
which
most
cases
requires
specific
groups
overcome
inherent
hydrophobic
nature
feature
organic
components
cage.
can
be
achieved
either
incorporating
water-solubilizing
with
negative/positive
charges,
polyethylene
glycol
chains,
etc.;
or
introducing
charges
directly
into
cage
structure
itself.
These
strategies
allow
preparing
diverse
including
cages’
anticancer
activity,
drug
delivery,
photodynamic
therapy,
recognition
molecules.
In
review
we
describe
selected
that
show
main
concepts
achieve
some
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(92), P. 13668 - 13678
Published: Jan. 1, 2023
Cages
at
work:
structural
tunability
results
in
tailored
properties,
which
makes
these
systems
suitable
for
countless
applications
sensing
and
separation
processes,
both
solution
the
solid
state.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(51)
Published: Oct. 27, 2023
Metal-organic
cages
(MOCs)
are
popular
host
architectures
assembled
from
ligands
and
metal
ions/nodes.
Assembling
structurally
complex,
low-symmetry
MOCs
with
anisotropic
cavities
can
be
limited
by
the
formation
of
statistical
isomer
libraries.
We
set
out
to
investigate
use
primary
coordination-sphere
engineering
(CSE)
bias
selectivity
within
homo-
heteroleptic
Pd
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(76), P. 10476 - 10487
Published: Jan. 1, 2024
Porous
organic
cages
(POCs)
are
constructed
from
purely
synthons
by
covalent
linkages
with
intrinsic
cavities
and
have
shown
potential
applications
in
many
areas.
However,
the
majority
of
POC
synthesis
methods
reported
thus
far
relied
on
dynamically
reversible
imine
linkages,
which
can
be
metastable
unstable
under
humid
or
harsh
chemical
conditions.
This
instability
significantly
hampers
their
research
prospects
practical
applications.
Consequently,
strategies
to
enhance
stability
POCs
modifying
bonds
developing
robust
imperative
for
realizing
full
these
materials.
In
this
review,
we
aim
highlight
recent
advancements
synthesizing
chemical-stable
through
approaches
associated
Additionally,
propose
further
creating
stable
discuss
future
opportunities
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
ABSTRACT
Long‐term
in
vivo
fluorescence
analysis
is
growing
into
a
sparkling
frontier
gaining
deep
insights
various
biological
processes.
Exploration
of
such
fluorophores
with
high
performance
still
remains
an
appealing
yet
significantly
challenging
task.
In
this
study,
we
have
elaborately
integrated
second
near‐infrared
(NIR‐II)
emissive
fluorophore
the
metal
Pt
self‐assembled
prism‐like
metallacage
M‐DBTP,
which
enables
intravital
long‐term
tracking
through
NIR‐II
imaging
technologies.
addition,
bioimaging
metallacage‐loaded
nanoparticles
(NPs)
indicated
extraordinary
photographic
on
mice
blood
vessels
and
rapid
clearance
M‐DBTP
NPs
from
within
7
h.
The
subsequent
transfer
to
bones
retention
bone
marrow
region
for
up
35
days
was
revealed
by
analysis,
confirmed
distribution
metabolism
inductively
coupled
plasma
optical
emission
spectrometer.
Moreover,
bright
them
well
perform
imaging‐guided
tumor
surgery.
