Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Advances in Nanodynamic Therapy for Cancer Treatment DOI Creative Commons
Bingchang Zhang, Yan Huang, Yong Huang

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(7), P. 648 - 648

Published: April 8, 2024

Nanodynamic therapy (NDT) exerts its anti-tumor effect by activating nanosensitizers to generate large amounts of reactive oxygen species (ROS) in tumor cells. NDT enhances tumor-specific targeting and selectivity leveraging the microenvironment (TME) mechanisms that boost immune responses. It also minimizes damage surrounding healthy tissues cytotoxicity cells, showing promise cancer treatment, with significant potential. This review covers research progress five major nanodynamic therapies: photodynamic (PDT), electrodynamic (EDT), sonodynamic (SDT), radiodynamic (RDT), chemodynamic (CDT), emphasizing role advanced nanotechnology development for purposes. The mechanisms, effects, challenges faced these NDTs are discussed, along their respective solutions enhancing efficacy, such as pH response, delivery, combined immunotherapy. Finally, this briefly addresses clinical translation NDT.

Language: Английский

Citations

7

Recent advances on DNAzyme for bioimaging, biosensing and cancer therapy DOI
Pei Sun,

Hongquan Gou,

Xinran Che

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(78), P. 10805 - 10821

Published: Jan. 1, 2024

DNAzymes, a class of single-stranded catalytic DNA with good stability, high activity, and easy synthesis, functionalization modification properties, have garnered significant interest in the realm biosensing bioimaging. Their integration fluorescent dyes or chemiluminescent moieties has led to remarkable bioimaging outcomes, while DNAzyme-based biosensors demonstrated robust sensitivity selectivity detecting metal ions, nucleic acids, proteins, enzyme activities, exosomes, bacteria microorganisms. In addition, by delivering DNAzymes into tumor cells, mRNA therein can be cleaved regulate expression corresponding which further propelled application cancer gene therapy synergistic therapy. This paper reviews strategies for screening attractive such as SELEX high-throughput sequencing, briefly describes amplification mainly include hairpin assembly (CHA), walker, hybridization chain reaction (HCR), origami, CRISPR-Cas12a, rolling circle (RCA), aptamers. applications bioimaging, biosensing, are also highlighted. Subsequently, possible challenges these practical pointed out, future research directions suggested.

Language: Английский

Citations

6

Tumor Microenvironment-Responsive MnOx-Mesoporous Carbon Nanoparticles for Enhanced Chemodynamic Synergistic Antitumor Therapy DOI
Rongrong Zhang, Tingting Wang, Haiyu Shen

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Developing nanomedicines with simultaneous diagnosis and treatment functions is a promising therapeutic strategy for cancer therapy. Herein, multifunctional manganese oxide-mesoporous carbon nanoparticles (MnOx-MCN NPs) were designed magnetic resonance imaging (MRI)-guided chemotherapy, photothermal therapy (PTT), chemodynamic (CDT). The excellent conversion efficiency (44.2%) outstanding fenton-like catalytic activity endowed MnOx-MCN NPs PTT/CDT synergistic Furthermore, their unique mesoporous structure, can also act as drug delivery carrier encapsulating chemotherapy agent doxorubicin (DOX). mild acid tumor microenvironment (TME) near-infrared (NIR) heat induced the release of DOX. In addition, NIR laser enhanced CDT NPs, thus generating chemotherapy/PTT/CDT effect. Extracellular experiments demonstrated that generated by irradiation could encourage generation •OH. More importantly, displayed superior anticancer both in vitro vivo. Such elaborately synthesized nanomaterial provides paradigm design other multifunction nanoagents.

Language: Английский

Citations

0

Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and in Vivo DOI Creative Commons
Whitney Lewis, A. P. Farrell, Subhashree Pradhan

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Language: Английский

Citations

0

Smart nucleic acid nanodrug delivery system for precision therapeutics DOI
Yu Chen,

Zongkang Guo,

Jing Li

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216673 - 216673

Published: April 3, 2025

Language: Английский

Citations

0

Nanoscaled metal-organic frameworks: charting a transformative path for cancer therapeutics and beyond DOI
Catalina Biglione, Tania Hidalgo, Patricia Horcajada

et al.

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(8), P. 2041 - 2045

Published: May 16, 2024

Language: Английский

Citations

0

Advancing DNAzyme Technology in Tumor Treatment DOI Open Access
Jianping Peng, Nini Wang, Rong Xu

et al.

Catalysts, Journal Year: 2024, Volume and Issue: 14(11), P. 795 - 795

Published: Nov. 7, 2024

DNAzyme-based gene therapy has received great interest in the treatment of cancer and other diseases. Despite its considerable potential clinical applications, vivo therapeutic efficacy DNAzymes is still unsatisfactory, mainly due to challenges such as poor stability, inadequate catalytic activity, insufficient target specificity. With rapid development nucleic acid chemistry nanomedicine, substantial efforts have been dedicated recent years designing nanoplatforms with enhanced efficacy. In addition, extensive combinations strategies led many synergistic therapies improved effects. This review focuses on advance treatment. It first summarizes solutions proposed address each key tumor therapy, from perspectives DNA sequence design, construction organic/inorganic nanosystems, regulation by environmental factors. Next, it reviews different categories combined using therapy. Finally, future trends well suggestions field are discussed detail.

Language: Английский

Citations

0

Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Citations

0