Advances in Nanodynamic Therapy for Cancer Treatment
Nanomaterials,
Journal Year:
2024,
Volume and Issue:
14(7), P. 648 - 648
Published: April 8, 2024
Nanodynamic
therapy
(NDT)
exerts
its
anti-tumor
effect
by
activating
nanosensitizers
to
generate
large
amounts
of
reactive
oxygen
species
(ROS)
in
tumor
cells.
NDT
enhances
tumor-specific
targeting
and
selectivity
leveraging
the
microenvironment
(TME)
mechanisms
that
boost
immune
responses.
It
also
minimizes
damage
surrounding
healthy
tissues
cytotoxicity
cells,
showing
promise
cancer
treatment,
with
significant
potential.
This
review
covers
research
progress
five
major
nanodynamic
therapies:
photodynamic
(PDT),
electrodynamic
(EDT),
sonodynamic
(SDT),
radiodynamic
(RDT),
chemodynamic
(CDT),
emphasizing
role
advanced
nanotechnology
development
for
purposes.
The
mechanisms,
effects,
challenges
faced
these
NDTs
are
discussed,
along
their
respective
solutions
enhancing
efficacy,
such
as
pH
response,
delivery,
combined
immunotherapy.
Finally,
this
briefly
addresses
clinical
translation
NDT.
Language: Английский
Recent advances on DNAzyme for bioimaging, biosensing and cancer therapy
Pei Sun,
No information about this author
Hongquan Gou,
No information about this author
Xinran Che
No information about this author
et al.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(78), P. 10805 - 10821
Published: Jan. 1, 2024
DNAzymes,
a
class
of
single-stranded
catalytic
DNA
with
good
stability,
high
activity,
and
easy
synthesis,
functionalization
modification
properties,
have
garnered
significant
interest
in
the
realm
biosensing
bioimaging.
Their
integration
fluorescent
dyes
or
chemiluminescent
moieties
has
led
to
remarkable
bioimaging
outcomes,
while
DNAzyme-based
biosensors
demonstrated
robust
sensitivity
selectivity
detecting
metal
ions,
nucleic
acids,
proteins,
enzyme
activities,
exosomes,
bacteria
microorganisms.
In
addition,
by
delivering
DNAzymes
into
tumor
cells,
mRNA
therein
can
be
cleaved
regulate
expression
corresponding
which
further
propelled
application
cancer
gene
therapy
synergistic
therapy.
This
paper
reviews
strategies
for
screening
attractive
such
as
SELEX
high-throughput
sequencing,
briefly
describes
amplification
mainly
include
hairpin
assembly
(CHA),
walker,
hybridization
chain
reaction
(HCR),
origami,
CRISPR-Cas12a,
rolling
circle
(RCA),
aptamers.
applications
bioimaging,
biosensing,
are
also
highlighted.
Subsequently,
possible
challenges
these
practical
pointed
out,
future
research
directions
suggested.
Language: Английский
Tumor Microenvironment-Responsive MnOx-Mesoporous Carbon Nanoparticles for Enhanced Chemodynamic Synergistic Antitumor Therapy
ACS Applied Nano Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Developing
nanomedicines
with
simultaneous
diagnosis
and
treatment
functions
is
a
promising
therapeutic
strategy
for
cancer
therapy.
Herein,
multifunctional
manganese
oxide-mesoporous
carbon
nanoparticles
(MnOx-MCN
NPs)
were
designed
magnetic
resonance
imaging
(MRI)-guided
chemotherapy,
photothermal
therapy
(PTT),
chemodynamic
(CDT).
The
excellent
conversion
efficiency
(44.2%)
outstanding
fenton-like
catalytic
activity
endowed
MnOx-MCN
NPs
PTT/CDT
synergistic
Furthermore,
their
unique
mesoporous
structure,
can
also
act
as
drug
delivery
carrier
encapsulating
chemotherapy
agent
doxorubicin
(DOX).
mild
acid
tumor
microenvironment
(TME)
near-infrared
(NIR)
heat
induced
the
release
of
DOX.
In
addition,
NIR
laser
enhanced
CDT
NPs,
thus
generating
chemotherapy/PTT/CDT
effect.
Extracellular
experiments
demonstrated
that
generated
by
irradiation
could
encourage
generation
•OH.
More
importantly,
displayed
superior
anticancer
both
in
vitro
vivo.
Such
elaborately
synthesized
nanomaterial
provides
paradigm
design
other
multifunction
nanoagents.
Language: Английский
Signal Transduction Strategies for DNAzyme-Based Sensing and Imaging of Metal Ions in Cells and in Vivo
Chemical & Biomedical Imaging,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Language: Английский
Smart nucleic acid nanodrug delivery system for precision therapeutics
Yu Chen,
No information about this author
Zongkang Guo,
No information about this author
Jing Li
No information about this author
et al.
Coordination Chemistry Reviews,
Journal Year:
2025,
Volume and Issue:
535, P. 216673 - 216673
Published: April 3, 2025
Language: Английский
Nanoscaled metal-organic frameworks: charting a transformative path for cancer therapeutics and beyond
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(8), P. 2041 - 2045
Published: May 16, 2024
Language: Английский
Advancing DNAzyme Technology in Tumor Treatment
Catalysts,
Journal Year:
2024,
Volume and Issue:
14(11), P. 795 - 795
Published: Nov. 7, 2024
DNAzyme-based
gene
therapy
has
received
great
interest
in
the
treatment
of
cancer
and
other
diseases.
Despite
its
considerable
potential
clinical
applications,
vivo
therapeutic
efficacy
DNAzymes
is
still
unsatisfactory,
mainly
due
to
challenges
such
as
poor
stability,
inadequate
catalytic
activity,
insufficient
target
specificity.
With
rapid
development
nucleic
acid
chemistry
nanomedicine,
substantial
efforts
have
been
dedicated
recent
years
designing
nanoplatforms
with
enhanced
efficacy.
In
addition,
extensive
combinations
strategies
led
many
synergistic
therapies
improved
effects.
This
review
focuses
on
advance
treatment.
It
first
summarizes
solutions
proposed
address
each
key
tumor
therapy,
from
perspectives
DNA
sequence
design,
construction
organic/inorganic
nanosystems,
regulation
by
environmental
factors.
Next,
it
reviews
different
categories
combined
using
therapy.
Finally,
future
trends
well
suggestions
field
are
discussed
detail.
Language: Английский
Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy
Zhi-Hang He,
No information about this author
Hanxiao Tang,
No information about this author
Yanna Pan
No information about this author
et al.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
The
oxygen
consumption
during
chemodynamic
therapy
(CDT)
can
lead
to
severe
cellular
hypoxia,
resulting
in
an
increase
the
hypoxia
inducible
factor-1α
(HIF-1α)
level,
which
hinders
effectiveness
of
CDT
and
induces
tumor
metastasis.
Here,
we
propose
a
strategy
synergistic
between
HIF-1α
inhibitor
avoid
limitations
reduce
risk
Herein,
based
on
coordination
Fe3+
apigenin
(API,
inhibitor),
constructed
hyaluronic
acid
(HA)-modified
API-Fe
nanoparticles
(AF@HA
NPs)
for
synergetic
chemotherapy
glutathione
(GSH)-activated
self-enhancing
CDT.
AF@HA
NPs
have
high
drug
loading
capacity,
stability,
biocompatibility.
Furthermore,
overexpressed
GSH
cancer
cells
Fe2+,
weakened
API
Fe,
promoted
release
chemotherapy.
Fe2+
could
react
with
endogenous
H2O2
generate
hydroxyl
groups
In
addition,
released
inhibit
expression
sensitivity
reactive
species
(ROS),
thereby
achieving
effect
results
vitro
vivo
experiments
indicated
that
effectively
growth
suppress
lung
metastasis
cells.
Language: Английский