Chemical Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 27, 2024
A covalent organic framework-based multifunctional nanomedicine, CuO2@COF-SNO, which can produce reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of tumors.
Language: Английский
Nanoscale, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Cancer remains a global health challenge, driving the need for advanced treatments. While transition metal dichalcogenides (TMDs) show promise in cancer therapy, their stability and efficacy require improvement. This study explores TMD-based composites as solution to enhance therapeutic potential. review begins by providing an overview of TMDs emphasizing preparation techniques fundamental properties. The focus is then shifted categorizing based on constituent materials, delving into various types, such TMD-organic, TMD-carbon, TMD-metal chalcogenide, TMD-metal, TMD-oxide composites, well more complex ternary multinary systems. We further explore key fabrication strategies, including hydrothermal/solvothermal methods surface deposition/coating techniques. Subsequently, applications treatment, chemotherapy, photothermal phototherapy, integrated combination therapies. Finally, critical challenges field perspectives potential directions future research are presented.
Language: Английский
Citations
2
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 215969 - 215969
Published: June 10, 2024
Language: Английский
Citations
8
Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(35), P. 2801 - 2812
Published: Aug. 7, 2024
As cancer therapy progresses, challenges remain due to the inherent drawbacks of conventional treatments such as chemotherapy, gene therapy, radiation and surgical removal. Moreover, their associated side effects, affect both cancerous normal cells, making photodynamic (PDT) an attractive alternative.
Language: Английский
Citations
7
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 24, 2024
The elevated level of hydrogen sulfide (H
Language: Английский
Citations
4
RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3098 - 3109
Published: Jan. 1, 2025
Tumor hypoxia still severely limits the antitumor efficiency. Herein, a free-radical initiator-based carrier-free smart nanobomb with oxygen-independent trimodal therapeutic effects for targeted therapy of hypoxic breast tumor at low dose.
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216578 - 216578
Published: March 4, 2025
Language: Английский
Citations
0
Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216645 - 216645
Published: April 4, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 27, 2025
Abstract Molybdenum disulfide (MoS₂) nanomaterials have attracted significant interest in cancer diagnosis and therapy due to their unique physicochemical properties. Due its extensive surface area adaptable structure, MoS₂ may engage with pharmaceuticals biomolecules via covalent non‐covalent interactions. This versatility enhances the sensitivity of identifying specific biomarkers, colloidal stability, tumor‐targeting capabilities. In near‐infrared (NIR) spectrum, exhibits strong optical absorption efficient photothermal conversion, making it suitable for NIR‐driven phototherapy regulated medication release. Functionalized nanocomposites react differently tumor microenvironment, which improves treatment effectiveness by increasing drug accumulation at sites decreasing off‐target effects on healthy tissues. Recent developments MoS₂‐based detection are reviewed this study, particular attention paid uses therapy, photodynamic biosensing, bioimaging. Additionally, looks difficulties potential applications cancer.
Language: Английский
Citations
0
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: 440, P. 137877 - 137877
Published: April 28, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Abstract Self‐supply of peroxo compounds has been regarded as a promising strategy to enhance Fenton chemistry‐based chemodynamic therapy (CDT). However, the inherent selectivity CDT will be affected after introducing peroxide‐supplementing functionality into agents due lack ability distinguish cancer cells from normal cells. Here, an intelligent nanomedicine is reported with both cascade‐responsive and peroxide self‐supplying performances for specific efficient treatment. Upon endocytosis acidic endo/lysosomes, comprising methyl linoleate hydroperoxide (MLH)‐loaded amorphous iron oxide nanoparticles (AIO@MLH NPs) can decomposed release MLH Fe 3+ that further reduced 2+ by endo/lysosomal six‐transmembrane epithelial antigen prostate (STEAP) metalloreductase activity, enabling occurrence Fenton‐type reaction between high‐active free radical generation, which causes damage cell apoptosis. Noteworthily, AIO@MLH NPs exhibit potent cytotoxicity cancerous rather than non‐cancerous benefiting overexpressed STEAP in multiple cancers, thereby leading precise tumor CDT. This work highlights use endogenous improve paves way development precision medicine.
Language: Английский
Citations
0