Macroscale Superlubricity of Gellan Gum-Based Hydrogel Enhanced with Hydrated Ions

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Ocular lubrication is a critical component of the biological system. Factors such as tear film instability and corneal epithelial damage can lead to increased friction on ocular surface during blinking, which negatively impacts quality life results in economic burden. Eye drops are commonly used therapeutic purposes. Due frequent movement (blinking, secretion, nasolacrimal drainage), their bioavailability low, requiring applications. In this study, methacylated gellan gum (GGMA) hydrogels were synthesized using methacrylic anhydride low-acyl raw materials. The elastic modulus GGMA hydrogel nearly threefold after introduction alkali metal ions. Macroscopic superlubricity was achieved experiments simulating environment. At contact pressure close 10 kPa, COF reduced 0.004. Detailed sophisticated simulations revealed underlying mechanism, showing that attributed hydration properties ions adsorbed onto surface. exhibits excellent lubricating properties, offering promising potential for enhancing supporting eye health.

Language: Английский

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Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Ocular nanogels have emerged as a promising therapeutic approach, and nanotechnology has speed up the growth of pharmaceutical medical technology sectors. The physiological anatomical barriers eye limit use traditional ocular preparations, which leads to low drug bioavailability brief retention period. This presents serious problem for patients, doctors, chemists. Nevertheless, can encapsulate medications within three-dimensional crosslinked polymeric networks provide controlled prolonged delivery by using particular structural layouts unique preparation techniques, improving efficacy patient compliance. Dextran its variants, naturally occurring polysaccharide, drawn lot interest in developing systems applications. Many dextran-based with customized geometries features been fabricated recently, such hydrogels, nanogels, magnetic nanoparticles, nanoemulsions, self-assembled micelles microparticles. review advancement potential treatment various conditions, cataract, conjunctivitis, glaucoma, dry syndrome, age-related macular degeneration, corneal ulcers. Moreover, process development assessing these nanomedicines, emphasizing their safety effectiveness established preclinical, toxicological, clinical assessments, patent updates, elaborated.

Language: Английский

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In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation

BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 13, 2025

Ocular drug delivery is challenging due to the eye's unique anatomy and physiology, which limit absorption distribution. Traditional methods like eye drops have poor bioavailability often require frequent dosing. In-situ gel systems, liquid formulations that transform into a upon contact with physiological conditions (pH, temperature, or ions in tear fluid), offer several advantages for ocular delivery. Ganciclovir was incorporated thermoresponsive situ base. Nine were prepared using cold technique 3² full factorial design. The physical properties of ganciclovir gel, including clarity, pH, viscosity, gelation time, scrutinized. In vitro release assessed dialysis membrane method, toxicity evaluated rabbit model. Poloxamer 407 HPMC E-50 LV used prepare design analyzing effects varying concentrations on gel's time. optimized in-situ formulation (Batch B5) contained 15% w/v poloxamer 1% LV, achieving viscosity 64.81 cPs, temperature 39.0 °C time 183 s. This demonstrated better permeability sustained than commercial formulation. studies confirmed non-irritating well-tolerated. Overall, showed suitable properties, over 12 h, significant potential enhancing treatment efficacy infections. These findings confirm preparation improves permeation prolongs retention thus its therapeutic efficacy. Its prolonged make it promising alternative conventional drops, offering patient compliance

Language: Английский

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Green synthesis of CeO2 nanoparticles supported over silica gel: Its catalytic activity in the synthesis of pyrazolo[3,4-b]pyridines and its performance for the treatment of retinal damage in diabetic rat

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123598 - 123598

Published: March 1, 2025

Language: Английский

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