State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems DOI Creative Commons
Meera Alex, Nour AlSawaftah, Ghaleb A. Husseini

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(7), P. 2926 - 2926

Published: March 30, 2024

Over the past few decades, notable advancements have been made in field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral administration. This comprehensive review aims enhance understanding this method by examining various techniques, skin’s role as barrier TDDS, factors affecting skin diffusion, and current challenges TDDSs. The primary focus analysis centers on TDDSs utilizing hydrogels. A thorough exploration hydrogel fundamentals, encompassing structure, properties, synthesis, is provided underscore importance hydrogels carriers delivery. concluding section delves into strategies for hydrogel-based delivery, addressing exploring future directions.

Language: Английский

Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management DOI Creative Commons
Shery Jacob, Anroop B. Nair, Jigar Shah

et al.

Pharmaceutics, Journal Year: 2021, Volume and Issue: 13(3), P. 357 - 357

Published: March 8, 2021

The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, controllable degradability. Functionalization strategies overcome the deficiencies conventional expand role advanced such DNA are extensively discussed this review. Different types cross-linking techniques, materials utilized, procedures, advantages, disadvantages covering tabulated. application hydrogels, particularly buccal, oral, vaginal, transdermal drug delivery systems, described. review also focuses on composite with enhanced properties that being developed meet diverse demand wound dressing materials. unique advantages hydrogel nanoparticles targeted intracellular various therapeutic agents explained. Furthermore, different hydrogel-based utilized for tissue engineering applications fabrication contact lens discussed. article provides an overview selected examples commercial products launched area oral ocular systems Hydrogels can be prepared a wide variety achieving biostable, bioresorbable, biodegradable polymer matrices, whose mechanical degree swelling tailored specific application. These features give them promising future fields applied biomedicine.

Language: Английский

Citations

306
Conductive Hydrogel‐Based Electrodes and Electrolytes for Stretchable and Self‐Healable Supercapacitors DOI
Tao Cheng, Yizhou Zhang, Shi Wang

et al.

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(24)

Published: April 9, 2021

Abstract Stretchable self‐healing supercapacitors (SCs) can operate under extreme deformation and restore their initial properties after damage with considerably improved durability reliability, expanding opportunities in numerous applications, including smart wearable electronics, bioinspired devices, human–machine interactions, etc. It is challenging, however, to achieve mechanical stretchability self‐healability energy storage technologies, wherein the key issue lies exploitation of ideal electrode electrolyte materials exceptional ability besides conductivity. Conductive hydrogels (CHs) possess unique hierarchical porous structure, high electrical/ionic conductivity, broadly tunable physical chemical through molecular design structure regulation, holding tremendous promise for stretchable SCs. Hence, this review innovatively constructed a focus on CH based electrodes electrolytes First, common synthetic approaches CHs are introduced; then stretching strategies involved systematically elaborated; followed by an explanation conductive mechanism CHs; focusing CH‐based SCs; subsequently, application SCs electronics discussed; finally, conclusion drawn along views challenges future research directions regarding field

Language: Английский

Citations

245
Stimuli-responsive transdermal microneedle patches DOI Creative Commons
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen

et al.

Materials Today, Journal Year: 2021, Volume and Issue: 47, P. 206 - 222

Published: May 20, 2021

Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the

Language: Английский

Citations

196
Recent Advances in Intelligent Wearable Medical Devices Integrating Biosensing and Drug Delivery DOI

Minhong Tan,

Yang Xu,

Ziqi Gao

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(27)

Published: Jan. 10, 2022

Abstract The primary roles of precision medicine are to perform real‐time examination, administer on‐demand medication, and apply instruments continuously. However, most current therapeutic systems implement these processes separately, leading treatment interruption limited recovery in patients. Personalized healthcare smart medical have greatly promoted research on development biosensing drug‐delivery integrated systems, with intelligent wearable devices (IWMDs) as typical which received increasing attention because their non‐invasive customizable nature. Here, the latest progress IWMDs is reviewed, including mechanisms integrating drug delivery. challenges future directions also discussed.

Language: Английский

Citations

116
Rational Design of Smart Hydrogels for Biomedical Applications DOI Creative Commons
Yanyu Zhang, Yishun Huang

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 8

Published: Feb. 4, 2021

Hydrogels are polymeric three-dimensional network structures with high water content. Due to their superior biocompatibility and low toxicity, hydrogels play a significant role in the biomedical fields. categorized by composition from natural polymers synthetic polymers. To meet complicated situation applications, suitable host–guest supramolecular interactions rationally selected. This review will have an introduction of hydrogel classification based on formulation molecules, then discussion over rational design intelligent environmental stimuli such as temperature, irradiation, pH, targeted biomolecules. Further, applications designed smart field be presented, tissue repair, drug delivery, cancer therapy. Finally, perspectives challenges outlined.

Language: Английский

Citations

109
Smart stimuli-responsive implantable drug delivery systems for programmed and on-demand cancer treatment: An overview on the emerging materials DOI

Zahra Mazidi,

Sanaz Javanmardi, Seyed Morteza Naghib

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 433, P. 134569 - 134569

Published: Jan. 7, 2022

Language: Английский

Citations

93
Harvesting Blue Energy Based on Salinity and Temperature Gradient: Challenges, Solutions, and Opportunities DOI
Masoud Rastgar,

Kazem Moradi,

Cassie Burroughs

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(16), P. 10156 - 10205

Published: July 31, 2023

Greenhouse gas emissions associated with power generation from fossil fuel combustion account for 25% of global and, thus, contribute greatly to climate change. Renewable energy sources, like wind and solar, have reached a mature stage, costs aligning those fuel-derived but suffer the challenge intermittency due variability sunlight. This study aims explore viability salinity gradient power, or "blue energy", as clean, renewable source uninterrupted, base-load generation. Harnessing river estuaries worldwide could meet substantial portion electricity demand (approximately 7%). Pressure retarded osmosis (PRO) reverse electrodialysis (RED) are more prominent technologies blue harvesting, whereas thermo-osmotic conversion (TOEC) is emerging new promise. review scrutinizes obstacles encountered in developing osmotic using membrane-based methods presents potential solutions overcome challenges practical applications. While certain strategies shown promise addressing some these obstacles, further research still required enhance efficiency feasibility processes, enabling their large-scale implementation harvesting.

Language: Английский

Citations

73
Porous Conductive Textiles for Wearable Electronics DOI
Yichun Ding, Jinxing Jiang, Yingsi Wu

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(4), P. 1535 - 1648

Published: Feb. 19, 2024

Over the years, researchers have made significant strides in development of novel flexible/stretchable and conductive materials, enabling creation cutting-edge electronic devices for wearable applications. Among these, porous textiles (PCTs) emerged as an ideal material platform electronics, owing to their light weight, flexibility, permeability, wearing comfort. This Review aims present a comprehensive overview progress state art utilizing PCTs design fabrication wide variety integrated systems. To begin with, we elucidate how revolutionize form factors electronics. We then discuss preparation strategies PCTs, terms raw processes, key properties. Afterward, provide detailed illustrations are used basic building blocks fabricate intrinsically flexible or stretchable devices, including sensors, actuators, therapeutic energy-harvesting storage displays. further describe techniques systems either by hybridizing conventional off-the-shelf rigid components with integrating multiple fibrous PCTs. Subsequently, highlight some important application scenarios healthcare, sports training, converging technologies, professional specialists. At end Review, challenges perspectives on future research directions give overall conclusions. As demand more personalized interconnected continues grow, PCT-based wearables hold immense potential redefine landscape technology reshape way live, work, play.

Language: Английский

Citations

71
Soft bioelectronics for the management of cardiovascular diseases DOI
Sung‐Hyuk Sunwoo, Sang Ihn Han, Chan Soon Park

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(1), P. 8 - 24

Published: Sept. 29, 2023

Language: Английский

Citations

59
An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery DOI Creative Commons
Yan Zhou, Xiaoteng Jia, Daxin Pang

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Jan. 18, 2023

Abstract Wearable transdermal iontophoresis eliminating the need for external power sources offers advantages patient-comfort when deploying epidermal diseases treatments. However, current self-powered based on energy harvesters is limited to support efficient therapeutic administration over long-term operation, owing low and inconsistent supply. Here we propose a simplified wearable patch with built-in Mg battery controllable delivery. This system decreases complexity form factors by using viologen-based hydrogels as an integrated drug reservoir cathode material, conventional interface impedance between electrode reservoir. The redox-active polyelectrolyte hydrogel high density of 3.57 mWh cm −2 , optimal bioelectronic ultra-soft nature tissue-interface impedance. delivery dosage can be readily manipulated tuning viologen stimulation mode. demonstrates effective treatment imiquimod-induced psoriasis mouse. Considering being reliable supply, configuration, electrical skin-device interface, this battery-powered may provide new non-invasive chronic diseases.

Language: Английский

Citations

51