Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 222, P. 113129 - 113129
Published: Jan. 4, 2023
Language: Английский
ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(3), P. 971 - 1012
Published: Feb. 28, 2022
Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup resistances. However, significant technological advancements have been made in terms superior modes delivery over the last few decades. Technical capability analyzing molecular mechanisms tumor biology, nanotechnology─particularly development biocompatible nanoparticles, surface modification techniques, microelectronics, material sciences─has increased. As a result, number nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency developed. This particular maneuver enables introduction substance body by controlling rate, time, place is defined system (NDDS). Because their versatility ability incorporate features water solubility, stability, biocompatibility, degradability, reverse resistance, they attracted interest scientific community, general, nanotechnologists well biomedical scientists. To keep pace rapid advancement nanotechnology, technical aspects recent NDDSs prospects need be reported coherently. address these ongoing issues, this review article provides an overview different lipids, polymers, inorganic nanoparticles. In addition, also reports challenges current points out prospective research directions nanocarriers. From our focused review, we conclude still now most advanced potent field application lipid-based, while significantly potential fields include polymer-based NDDSs. despite promises, remain practical implementations dosage caution should exercised regarding biocompatibility materials. Considering objectively, on will particularly small-to-large scale industrial researchers academicians expertise delivery, research, nanotechnology.
Language: Английский
Citations
254
Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)
Published: Aug. 29, 2023
Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.
Language: Английский
Citations
84
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 435 - 435
Published: Feb. 17, 2022
Cancer continues to represent a global health concern, imposing an ongoing need research for better treatment alternatives. In this context, nanomedicine seems be the solution existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered advantageous properties of nanoscale metals, review aims present metal-based nanoparticles that are most frequently employed applications. This paper follows description relevant made metal derivatives, hybrids, alloys, further discussing more detail their potential applications management, ranging from delivery chemotherapeutics, vaccines, genes ablative hyperthermia therapies theranostic platforms.
Language: Английский
Citations
71
Big Data and Cognitive Computing, Journal Year: 2023, Volume and Issue: 7(3), P. 147 - 147
Published: Aug. 30, 2023
The future of innovative robotic technologies and artificial intelligence (AI) in pharmacy medicine is promising, with the potential to revolutionize various aspects health care. These advances aim increase efficiency, improve patient outcomes, reduce costs while addressing pressing challenges such as personalized need for more effective therapies. This review examines major robotics AI pharmaceutical medical fields, analyzing advantages, obstacles, implications In addition, prominent organizations research institutions leading way these technological advancements are highlighted, showcasing their pioneering efforts creating utilizing state-of-the-art solutions medicine. By thoroughly current state care exploring possibilities further progress, this work aims provide readers a comprehensive understanding transformative power evolution healthcare sector. Striking balance between embracing technology preserving human touch, investing R&D, establishing regulatory frameworks within ethical guidelines will shape systems. seamless integration systems benefit patients providers.
Language: Английский
Citations
57
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 868 - 868
Published: March 7, 2023
The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools diagnosis treatment in the future. Due to their tunable morphologies superior properties, multifunctional magnetic nanomaterials hybrid nanostructures can designed as specific carriers drugs, imaging agents, theranostics. Multifunctional are promising theranostic agents due ability diagnose combine therapies. This review provides a comprehensive overview development advanced combining optical providing photoresponsive platforms medical applications. Moreover, this discusses various innovative developments using nanostructures, including drug delivery, treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal resonance imaging, tissue engineering. Additionally, artificial intelligence (AI) used optimize material properties based on predicted interactions with cell membranes, vasculature, biological fluid, immune system enhance effectiveness therapeutic agents. Furthermore, an AI approaches assess practical utility Finally, presents current knowledge perspectives systems models.
Language: Английский
Citations
51
Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(6), P. 2928 - 2941
Published: May 22, 2023
Gelatin methacryloyl (GelMA) hydrogels have been extensively used for drug delivery and tissue engineering applications due to their good biocompatibility, biodegradability, controllable photocurable efficiency. Phosphate buffer solution (PBS) is the most widely reaction system GelMA synthesis. However, carbonate–bicarbonate (CBS) has tried recently synthesizing its high there a lack of systematic investigation into possible differences in structure properties synthesized PBS CBS, respectively. Therefore, current study, molecules with two degrees methacryloylation (∼20 ∼80%) were under CBS systems, respectively, comparable conditions. The results showed that because functionalization methacrylate groups gelatin chains, which could interfere intrachain interchain interactions, such as hydrogen bonding, had distinct physical structures exhibited different comparison those produced CBS. higher gel–sol transition temperatures better efficiencies, mechanical strength, biological properties. In contrast, advantages swelling performance microstructures, pore sizes porosities. addition, possessing degree (the "GelMA-PH" polymer) great potential three-dimensional (3D) bioprinting. This focused study gained helpful new insights can provide guidance on application 3D printing engineering.
Language: Английский
Citations
45
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 737 - 767
Published: Feb. 14, 2024
Language: Английский
Citations
25
Polymers, Journal Year: 2022, Volume and Issue: 14(12), P. 2365 - 2365
Published: June 11, 2022
Hydrogels, as interconnected networks (polymer mesh; physically, chemically, or dynamic crosslinked networks) incorporating a high amount of water, present structural characteristics similar to soft natural tissue. They enable the diffusion different molecules (ions, drugs, and grow factors) have ability take over action external factors. Their nature provides wide variety raw materials inspiration for functional matter obtained by complex mechanisms hierarchical self-assembly. Over last decade, many studies focused on developing innovative high-performance materials, with new improved functions, mimicking biological structures at length scales. Hydrogels synthetic origin can be engineered bulk micro- nanoparticles, patches, membranes, supramolecular pathways, bio-inks, etc. The specific features hydrogels make them suitable applications, including tissue engineering scaffolds (repair/regeneration), wound healing, drug delivery carriers, robotics, sensors, actuators, catalysis, food safety, hygiene products. This review is recent advances in field bioinspired that serve platforms life-science applications. A brief outlook actual trends future directions also presented.
Language: Английский
Citations
48
Advanced Science, Journal Year: 2023, Volume and Issue: 10(14)
Published: March 19, 2023
The natural design and coupling of biological structures are the root realizing high strength, toughness, unique functional properties biomaterials. Advanced architecture is applied to many materials, including metal inorganic nonmetallic polymer so on. To improve performance advanced designed can be enhanced by bionics structure, optimization structural parameters, multiple types structures. Herein, progress materials reviewed, strengthening mechanisms different highlighted, impact on discussed. Architecture at micro level, such as mechanical, electrical, thermal conductivity. synergistic effect structure makes traditional move toward thus enriching macroproperties materials. Finally, challenges opportunities innovation in improving material
Language: Английский
Citations
39
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(20)
Published: March 11, 2023
Abstract Immune cells exhibit great potential as carriers of nanomedicine, attributed to their high tolerance internalized nanomaterials and targeted accumulation in inflammatory tissues. However, the premature efflux nanomedicine during systemic delivery slow infiltration into tissues have limited translational applications. Herein, a motorized cell platform carrier for highly efficient lungs effective treatment acute pneumonia are reported. β‐Cyclodextrin adamantane respectively modified manganese dioxide nanoparticles intracellularly self‐assembled large aggregates mediated via host‐guest interactions, effectively inhibit nanoparticles, catalytically consume/deplete H 2 O alleviate inflammation, generate propel macrophage movement rapid tissue infiltration. With curcumin loaded MnO macrophages carry intracellular nano‐assemblies rapidly chemotaxis‐guided, self‐propelled movement, immunoregulation induced by aggregates.
Language: Английский
Citations
32