Coronavirus Disease 2019–COVID-19

Clinical Microbiology Reviews, Journal Year: 2020, Volume and Issue: 33(4)

Published: June 23, 2020

In recent decades, several new diseases have emerged in different geographical areas, with pathogens including Ebola virus, Zika Nipah and coronaviruses (CoVs). Recently, a type of viral infection Wuhan City, China, initial genomic sequencing data this virus do not match previously sequenced CoVs, suggesting novel CoV strain (2019-nCoV), which has now been termed severe acute respiratory syndrome CoV-2 (SARS-CoV-2). Although coronavirus disease 2019 (COVID-19) is suspected to originate from an animal host (zoonotic origin) followed by human-to-human transmission, the possibility other routes should be ruled out.

Language: Английский

---

Digital technologies in the public-health response to COVID-19

Nature Medicine, Journal Year: 2020, Volume and Issue: 26(8), P. 1183 - 1192

Published: Aug. 1, 2020

Digital technologies are being harnessed to support the public-health response COVID-19 worldwide, including population surveillance, case identification, contact tracing and evaluation of interventions on basis mobility data communication with public. These rapid responses leverage billions mobile phones, large online datasets, connected devices, relatively low-cost computing resources advances in machine learning natural language processing. This Review aims capture breadth digital innovations for worldwide their limitations, barriers implementation, legal, ethical privacy barriers, as well organizational workforce barriers. The future public health is likely become increasingly digital, we review need alignment international strategies regulation, use strengthen pandemic management, preparedness other infectious diseases. has resulted an accelerated development applications health, symptom monitoring tracing. Their potential wide ranging must be integrated into conventional approaches best effect.

Language: Английский

---

Assay Techniques and Test Development for COVID-19 Diagnosis

ACS Central Science, Journal Year: 2020, Volume and Issue: 6(5), P. 591 - 605

Published: April 30, 2020

An ongoing theme of the COVID-19 pandemic is need for widespread availability accurate and efficient diagnostic testing detection SARS-CoV-2 antiviral antibodies in infected individuals. This report describes various assay techniques tests diagnosis. Most early RNA rely on reverse transcription-polymerase chain reaction, but isothermal nucleic acid amplification assays, including transcription-mediated CRISPR-based methodologies, are promising alternatives. Identification individuals who have developed to virus requires serological tests, enzyme-linked immunosorbent (ELISA) lateral flow immunoassay. also provides an overview current development products facilitate future improvement innovation.

Language: Английский

---

Diagnostics for SARS-CoV-2 infections

Nature Materials, Journal Year: 2021, Volume and Issue: 20(5), P. 593 - 605

Published: Feb. 15, 2021

Language: Английский

---

Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 7617 - 7627

Published: May 21, 2020

The current outbreak of the pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) demands its rapid, convenient, and large-scale diagnosis to downregulate spread within as well across communities. But reliability, reproducibility, selectivity majority such diagnostic tests fail when they are tested either a viral load at early representation or gene mutated during spread. In this regard, selective "naked-eye" detection SARS-CoV-2 is highly desirable, which can be without accessing any advanced instrumental techniques. We herein report development colorimetric assay based on gold nanoparticles (AuNPs), capped with suitably designed thiol-modified antisense oligonucleotides (ASOs) specific for N-gene (nucleocapsid phosphoprotein) SARS-CoV-2, could used diagnosing positive COVID-19 cases 10 min from isolated RNA samples. ASO-capped AuNPs agglomerate selectively in presence target sequence demonstrate change surface plasmon resonance. Further, addition RNaseH cleaves strand RNA-DNA hybrid leading visually detectable precipitate solution mediated additional agglomeration among AuNPs. has been monitored MERS-CoV limit 0.18 ng/μL having load. Thus, study reports visual causative virus, requirement sophisticated

Language: Английский

---

Assessment and characterisation of post‐COVID‐19 manifestations

International Journal of Clinical Practice, Journal Year: 2020, Volume and Issue: 75(3)

Published: Sept. 29, 2020

Post-COVID-19 symptoms and diseases appeared on many survivors from COVID-19 which are similar to that of the post-severe acute respiratory syndrome (SARS) fatigue. Hence, study aims investigate characterise manifestations appear after eradication coronavirus infection its relation disease severity.About 287 were included in study, each received a questionnaire divided into three main parts starting subjects' demographic data, data about status other comorbidities subject, finally post-COVID-19 manifestations. Response surface plots produced visualise link between several factors.Only 10.8% all subjects have no manifestation recovery while large percentage suffered diseases. The most common symptom reported was fatigue (72.8%), more critical like stroke, renal failure, myocarditis pulmonary fibrosis by few percent subjects. There relationship presence severity disease. Also, related manifestations.The is largely post-SARS syndrome. All recovered should undergo long-term monitoring for evaluation treatment conditions might be precipitated with new infection.

Language: Английский

---

Toward Nanotechnology-Enabled Approaches against the COVID-19 Pandemic

ACS Nano, Journal Year: 2020, Volume and Issue: 14(6), P. 6383 - 6406

Published: June 10, 2020

The COVID-19 outbreak has fueled a global demand for effective diagnosis and treatment as well mitigation of the spread infection, all through large-scale approaches such specific alternative antiviral methods classical disinfection protocols. Based on an abundance engineered materials identifiable by their useful physicochemical properties versatile chemical functionalization, nanotechnology offers number to cope with this emergency. Here, multidisciplinary Perspective encompassing diverse fields virology, biology, medicine, engineering, chemistry, science, computational we outline how nanotechnology-based strategies can support fight against COVID-19, infectious diseases in general, including future pandemics. Considering what know so far about life cycle virus, envision key steps where could counter disease. First, nanoparticles (NPs) offer protocols used healthcare settings, thanks intrinsic antipathogenic and/or ability inactivate viruses, bacteria, fungi, or yeasts either photothermally via photocatalysis-induced reactive oxygen species (ROS) generation. Nanotechnology tools SARS-CoV-2 patients also be explored. In case, nanomaterials deliver drugs pulmonary system inhibit interaction between angiotensin-converting enzyme 2 (ACE2) receptors viral S protein. Moreover, concept "nanoimmunity design" help us design immune modulation, stimulating suppressing response, which would find applications context vaccine development counteracting cytokine storm, respectively. addition disease prevention therapeutic potential, important roles diagnostics, potential simple, fast, cost-effective assays monitor presence related biomarkers. summary, is critical will vital when preparing

Language: Английский

---

Overcoming the bottleneck to widespread testing: a rapid review of nucleic acid testing approaches for COVID-19 detection

RNA, Journal Year: 2020, Volume and Issue: 26(7), P. 771 - 783

Published: May 1, 2020

The current COVID-19 pandemic presents a serious public health crisis, and better understanding of the scope spread virus would be aided by more widespread testing. Nucleic-acid-based tests currently offer most sensitive early detection COVID-19. However, “gold standard” test pioneered U.S. Centers for Disease Control Prevention takes several hours to complete requires extensive human labor, materials such as RNA extraction kits that could become in short supply, relatively scarce qPCR machines. It is clear huge effort needs made scale up testing orders magnitude. There thus pressing need evaluate alternative protocols, reagents, approaches allow nucleic-acid continue face these potential shortages. has been tremendous explosion number papers written within first weeks evaluating advances, comparable alternatives “gold-standard” CDC RT-PCR test. Here we present collection recent advances nucleic acid testing, including both peer-reviewed preprint articles. Due rapid developments during this have included many publications possible, but cited sources not yet peer-reviewed, so urge researchers further validate results their own laboratories. We hope review can urgently consolidate disseminate information aid designing implementing optimized protocols increase availability, accuracy, speed

Language: Английский

---

Safety of foods, food supply chain and environment within the COVID-19 pandemic

Trends in Food Science & Technology, Journal Year: 2020, Volume and Issue: 102, P. 293 - 299

Published: June 15, 2020

Language: Английский

---

Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19

American Journal of Infection Control, Journal Year: 2020, Volume and Issue: 49(1), P. 21 - 29

Published: July 10, 2020

Language: Английский

---