Photochemical Strategies toward Precision Targeting against Multidrug-Resistant Bacterial Infections

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14085 - 14122

Published: May 22, 2024

Infectious diseases pose a serious threat and substantial economic burden on global human public health security, especially with the frequent emergence of multidrug-resistant (MDR) bacteria in clinical settings. In response to this urgent need, various photobased anti-infectious therapies have been reported lately. This Review explores discusses several photochemical targeted antibacterial therapeutic strategies for addressing bacterial infections regardless their antibiotic susceptibility. contrast conventional therapies, these approaches facilitate precise targeting pathogenic and/or infectious microenvironments, effectively minimizing toxicity mammalian cells surrounding healthy tissues. The highlighted include photodynamic therapy, photocatalytic photothermal endogenous pigments-based photobleaching polyphenols-based photo-oxidation therapy. comprehensive exploration aims offer updated information development effective, convenient, safe, alternative counter growing MDR future.

Language: Английский

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ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: March 21, 2024

Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels cause oxidative damage to cells. A core-shell nanozyme, CeO

Language: Английский

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Z-scheme heterojunction photocatalyst formed by MOF-derived C-TiO2 and Bi2WO6 for enhancing degradation of oxytetracycline: Mechanistic insights and toxicity evaluation in the presence of a single active species

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 665, P. 41 - 59

Published: March 15, 2024

Language: Английский

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Engineering Atomic Ag₁–N₆ Sites with Enhanced Performance of Eradication Drug-Resistant Bacteria over Visible-Light-Driven Antibacterial Membrane

ACS Nano, Journal Year: 2024, Volume and Issue: 18(9), P. 7074 - 7083

Published: Feb. 22, 2024

Utilizing visible light for water disinfection is a more convenient, safe, and practical alternative to ultraviolet-light sterilization. Herein, we developed silver (Ag) single-atom anchored g-C3N4 (P-CN) nanosheets (Ag1/CN) then utilized spin-coating method fabricate the Ag1/CN-based-membrane effective antibacterial performance in natural domestic wastewater. The incorporated Ag single atom formed Ag1–N6 motif, which increased charge density around N atoms, resulting built-in electric field ∼17.2 times stronger than that of pure P-CN optimizing dynamics reactive oxygen species (ROS) production. Additionally, motif inhibited release ions, ensuring good biocompatibility. Based on first-principles calculation, adsorption energy O2 Ag1/CN (−0.32 eV) was lower (−0.07 eV), indicating loaded can barrier activation, generating extra *OH radicals cooperated with *O2– effectively neutralize bacteria. As result, powder-catalyst concentration 30 ppm demonstrated 99.9% efficiency against drug-resistant bacteria (Escherichia coli, Staphylococcus aureus, kanamycin-resistant Escherichia methicillin-resistant aureus) under visible-light irradiation 4 h. This efficacy 24.8 higher powder catalyst. Moreover, maintain bactericidal wastewater treatment using homemade flow device, demonstrating its potential disinfection. Notably, visible-light-driven catalyst outperformed majority reported g-C3N4-based catalysts/membranes.

Language: Английский

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A Novel L-Cys@Cu MOF Embedding onto Cotton Fiber Surfaces to Exert Excellent Antiviral and Antibacterial Effects

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(2), P. 444 - 457

Published: Feb. 6, 2024

Language: Английский

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