Diagnostic Modalities in Critical Care: Point-of-Care Approach DOI Creative Commons
Saša Rajšić, Robert Breitkopf, Mirjam Bachler

et al.

Diagnostics, Journal Year: 2021, Volume and Issue: 11(12), P. 2202 - 2202

Published: Nov. 25, 2021

The concept of intensive care units (ICU) has existed for almost 70 years, with outstanding development progress in the last decades. Multidisciplinary critically ill patients become an integral part every modern health system, ensuing improved and reduced mortality. Early recognition severe medical surgical illnesses, advanced prehospital organized immediate trauma centres led to a rise ICU patients. Due underlying disease its need complex mechanical support monitoring treatment, it is often necessary facilitate bed-side diagnostics. Immediate diagnostics are essential successful treatment life threatening conditions, early complications good quality care. Management incomprehensible without continuous sophisticated monitoring, bedside ultrasonography, diverse radiologic diagnostics, blood gas analysis, coagulation management, laboratory other point-of-care (POC) diagnostic modalities. Moreover, time acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, particular attention given POC techniques due additional concerns related risk infection transmission, patient healthcare workers safety potential adverse events relocation. This review summarizes most actual information on possible modalities critical care, special focus importance approach imaging procedures.

Language: Английский

Ultrafast Plasmonic Nucleic Acid Amplification and Real-Time Quantification for Decentralized Molecular Diagnostics DOI Creative Commons

Byoung‐Hoon Kang,

Kyung‐Won Jang,

Eun-Sil Yu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(7), P. 6507 - 6518

Published: March 27, 2023

Point-of-care real-time reverse-transcription polymerase chain reaction (RT-PCR) facilitates the widespread use of rapid, accurate, and cost-effective near-patient testing that is available to public. Here, we report ultrafast plasmonic nucleic acid amplification quantification for decentralized molecular diagnostics. The RT-PCR system features an thermocycler (PTC), a disposable plastic-on-metal (PoM) cartridge, ultrathin microlens array fluorescence (MAF) microscope. PTC provides photothermal cycling under white-light-emitting diode illumination precise temperature monitoring with integrated resistance detector. PoM thin film cartridge allows rapid heat transfer as well complete light blocking from excitation source, resulting in highly efficient PCR quantification. Besides, MAF microscope exhibits close-up high-contrast microscopic imaging. All systems were fully packaged palm size point-of-care testing. demonstrates diagnosis coronavirus disease-19 RNA virus within 10 min yields 95.6% efficiency, 96.6% classification accuracy preoperational test, 91% total percent agreement clinical diagnostic test. compact can decentralize primary care developing countries.

Language: Английский

Citations

24
Sensitive SERS detection of SARS-CoV‑2 spike protein based on Y‑shaped-aptasensor and AuNPs/COFs composites DOI

Yalin Xie,

Qiuju Li, Jiaxin Chen

et al.

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 394, P. 134470 - 134470

Published: Aug. 15, 2023

Language: Английский

Citations

24
CRISPR/Cas detection with nanodevices: moving deeper into liquid biopsy DOI
Huimin Kong, Ke Yi, Rachel L. Mintz

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(17), P. 2301 - 2319

Published: Jan. 1, 2024

This feature article summarises the latest advances, potential challenges, and future prospects of CRISPR/Cas gene-editing technologies in conjunction with emerging nanodevices for refinement precision liquid biopsy techniques.

Language: Английский

Citations

10
Catalytic hairpin assembly-and-cyclization aptasensing for AND-logic detection of protein- and RNA-targets in ribonucleoprotein DOI
Mingming Ding,

Yulin Yang,

Nian X. Sun

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117388 - 117388

Published: March 1, 2025

Language: Английский

Citations

1
Diagnostic Modalities in Critical Care: Point-of-Care Approach DOI Creative Commons
Saša Rajšić, Robert Breitkopf, Mirjam Bachler

et al.

Diagnostics, Journal Year: 2021, Volume and Issue: 11(12), P. 2202 - 2202

Published: Nov. 25, 2021

The concept of intensive care units (ICU) has existed for almost 70 years, with outstanding development progress in the last decades. Multidisciplinary critically ill patients become an integral part every modern health system, ensuing improved and reduced mortality. Early recognition severe medical surgical illnesses, advanced prehospital organized immediate trauma centres led to a rise ICU patients. Due underlying disease its need complex mechanical support monitoring treatment, it is often necessary facilitate bed-side diagnostics. Immediate diagnostics are essential successful treatment life threatening conditions, early complications good quality care. Management incomprehensible without continuous sophisticated monitoring, bedside ultrasonography, diverse radiologic diagnostics, blood gas analysis, coagulation management, laboratory other point-of-care (POC) diagnostic modalities. Moreover, time acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, particular attention given POC techniques due additional concerns related risk infection transmission, patient healthcare workers safety potential adverse events relocation. This review summarizes most actual information on possible modalities critical care, special focus importance approach imaging procedures.

Language: Английский

Citations

43