Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(5), P. 1323 - 1367

Published: March 14, 2024

Abstract Reactive oxygen species (ROS) and reactive nitrogen (RNS) are well recognized for playing a dual role, since they can be either deleterious or beneficial to biological systems. An imbalance between ROS production elimination is termed oxidative stress, critical factor common denominator of many chronic diseases such as cancer, cardiovascular diseases, metabolic neurological disorders (Alzheimer’s Parkinson’s diseases), other disorders. To counteract the harmful effects ROS, organisms have evolved complex, three-line antioxidant defense system. The first-line mechanism most efficient involves enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). This line plays an irreplaceable role in dismutation radicals (O 2 ·− ) hydrogen peroxide (H O ). removal by SOD prevents formation much more damaging peroxynitrite ONOO − + NO · → maintains physiologically relevant level nitric oxide (NO ), important molecule neurotransmission, inflammation, vasodilation. second-line pathway exogenous diet-derived small-molecule antioxidants. third-line ensured repair oxidized proteins biomolecules variety enzyme review briefly discusses endogenous (mitochondria, NADPH, xanthine oxidase (XO), Fenton reaction) (e.g., smoking, radiation, drugs, pollution) sources (superoxide radical, peroxide, hydroxyl peroxyl hypochlorous acid, peroxynitrite). Attention has been given system provided SOD, CAT, GPx. chemical molecular mechanisms enzymes, enzyme-related (cancer, cardiovascular, lung, metabolic, GPx4) cellular processes ferroptosis discussed. Potential therapeutic applications mimics recent progress metal-based (copper, iron, cobalt, molybdenum, cerium) nonmetal (carbon)-based nanomaterials with enzyme-like activities (nanozymes) also Moreover, attention action low-molecular-weight antioxidants (vitamin C (ascorbate), vitamin E (alpha-tocopherol), carotenoids β-carotene, lycopene, lutein), flavonoids quercetin, anthocyanins, epicatechin), (GSH)), activation transcription factors Nrf2, protection against diseases. Given that there discrepancy preclinical clinical studies, approaches may result greater pharmacological success therapies subject discussion.

Language: Английский

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Tumor-Generated Reactive Oxygen Species Storm for High-Performance Ferroptosis Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11492 - 11506

Published: June 7, 2023

Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the tumor environment (TME), which are unfavorable for reactive oxygen species (ROS) generation based on or Fenton-like reactions. The glutathione (GSH) overexpression TME can scavenge ROS abate FT performance. In this study, strategy storm specifically initiated by our developed nanoplatforms (TAF-HMON-CuP@PPDG) is proposed high-performance tumors. GSH initiates HMON degradation, resulting tamoxifen (TAF) copper (CuP) release TAF3-HMON-CuP3@PPDG. released TAF leads to enhanced acidification within cells, reacts with CuP producing Cu2+ H2O2. reaction between H2O2 generates Cu+, that Cu+ Cu2+, forming cyclic catalysis effect. generate GSSG. increased accelerate consumption decreases peroxidase 4 (GPX4) expression. All above reactions cells FT, demonstrated cancer tumor-bearing mice.

Language: Английский

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Ceria‐Based Therapeutic Antioxidants for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 16, 2023

Abstract The growing interest in nanomedicine over the last 20 years has carved out a research field called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are employed to intervene disease‐critical biomolecular processes. Among many kinds of catalytic/enzyme‐mimetic investigated thus far, ceria nanoparticles stand from others owing their unique scavenging properties against biologically noxious free radicals, including reactive oxygen species (ROS) and nitrogen (RNS), exerting enzyme mimicry nonenzymatic activities. Much effort been made utilize as self‐regenerating antioxidative anti‐inflammatory agents for various diseases, given detrimental effects ROS RNS therein that need alleviation. In this context, review is intended provide an overview what makes merit attention disease therapy. introductory part describes characteristics oxygen‐deficient metal oxide. pathophysiological roles then presented, well mechanisms nanoparticles. Representative examples recent ceria‐nanoparticle‐based therapeutics summarized categorization into organ types, followed discussion on remaining challenges future directions.

Language: Английский

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Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 474, P. 214861 - 214861

Published: Oct. 1, 2022

Language: Английский

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Fe(III)‐Naphthazarin Metal–Phenolic Networks for Glutathione‐Depleting Enhanced Ferroptosis–Apoptosis Combined Cancer Therapy

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 11, 2023

Abstract Nowadays, Fenton chemistry‐based chemodynamic therapy (CDT) is an emerging approach to killing tumor cells by converting endogenous H 2 O into cytotoxic hydroxyl radicals (·OH). However, the elimination of ·OH intracellular overexpressed glutathione (GSH) results in unsatisfactory antitumor efficiency. In addition, single mode consuming GSH and undesirable drug loading efficiency cannot guarantee efficient cancer effect. Herein, a simple one‐step strategy for construction Fe 3+ ‐naphthazarin metal–phenolic networks (FNP MPNs) with ultrahigh capacity, followed modification NH ‐PEG‐NH , developed. The carrier‐free FNP MPNs can be triggered acid GSH, rapidly release naphthazarin which further reduced 2+ that exerts catalytic activity produce abundant ·OH. Meanwhile, Michael addition between lead depletion thus achieve microenvironment (TME)‐triggered enhanced CDT, activating ferroptosis apoptosis. as T 1 ‐weighted contrast agent endows magnetic resonance imaging (MRI) functionality. Overall, this work debut ligands fabricate functional effectively depleting disrupting redox homeostasis, enhancing CDT effects, opens new perspectives on multifunctional synergistic therapy.

Language: Английский

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Synthesis of Bimetallic Nanoparticles and Applications—An Updated Review

Crystals, Journal Year: 2023, Volume and Issue: 13(4), P. 637 - 637

Published: April 7, 2023

The manipulation of matter at the atomic level (nanotechnology) has experienced an explosion in research interest recent years. Bimetallic nanoparticles are vital due to their high biocompatibility, stability and comparatively less toxicity. synthesis methods that include physical, chemical biological explored explained detail, along with advantages. They have a wide range applications synergistic properties including (in medicine agriculture), environmental application water treatment removal toxic contaminants), engineering nanosensors, nanochips nano-semiconductors) physical optics, catalysis paints). green approach is promising method can give rise more biocompatible bimetallic increasing pollution. However, despite these interesting attributes nanoparticle, there still much work be done improve biocompatibility because toxicity potentially hazardous effects.

Language: Английский

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Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(12), P. 1502 - 1514

Published: Oct. 26, 2023

Language: Английский

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Dual Active Centers Linked by a Reversible Electron Station as a Multifunctional Nanozyme to Induce Synergetically Enhanced Cascade Catalysis for Tumor-Specific Therapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(23), P. 12586 - 12600

Published: June 6, 2023

Nanozymes have shown great promise in reactive oxygen species (ROS)-mediated tumor therapy with mitigated side effects but are normally limited by the complex microenvironment (TME). Herein, to overcome adverse of TME, such as hypoxia and high endogenous glutathione (GSH), an aptamer-functionalized Pd@MoO3–x nano-hydrangea (A-Pd@MoO3–x NH) is constructed for high-efficiency cancer therapy. Utilizing irregular shape characteristics nano Pd, A-Pd@MoO3–x NH nanozyme simultaneously exposes catalase-like Pd(111) oxidase-like Pd(100) surface facets dual active centers. This can catalyze cascade enzymatic reactions negative caused accumulation cytotoxic superoxide (O2•–) radicals TME without any external stimuli. In addition, effectively degrade overexpressed (GSH) through redox reaction avoid nontherapeutic consumption O2•– radicals. More significantly, a reversible electron station, MoO3–x extract electrons from H2O2 decomposing on or GSH degradation transfer them back bridges few Mo–Pd bonds. synergistically enhance enzyme-like activities centers GSH-degrading ability enrich this way, selectively remarkably kill cells while keeping normal cell line unharmed.

Language: Английский

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