Cited by A Novel Ce─Mn Heterojunction‐Based Multi‐Enzymatic Nanozyme with Cancer‐Specific Enzymatic Activity and Photothermal Capacity for Efficient Tumor Combination Therapy

Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy DOI

Yue Li,

Zekun Du,

Yuan Zhang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 15, 2024

Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further enveloped within M1 macrophage membrane, tumor‐specific nanoagent constructed. This strategic integration effectively constrains the molecular motion AIEgen, leading to amplified NIR‐II fluorescence brightness PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H 2 O generate oxygen boost efficacy, PB's NIR absorption also intensifies photoacoustic imaging effect. provides comprehensive information photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, not only significantly inhibits growth, but generates whole‐cell therapeutic vaccine protect mice from tumor rechallenge. In highly malignant post‐surgery models, enables both accurate identification residual tumors efficient inhibition postoperative recurrence pulmonary metastasis. study will offer valuable insights creating efficacious multifaceted protocols.

Language: Английский

Citations

A NIR-II light-modulated injectable self-healing hydrogel for synergistic photothermal/chemodynamic/chemo-therapy of melanoma and wound healing promotion DOI

Xiaohua Huang, Lei Tang, Lin Xu

et al.

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(38), P. 7717 - 7731

Published: Jan. 1, 2022

A novel NIR-II activatable multi-responsive self-healing hydrogel with inherent photothermal, chemodynamic, and antibacterial activity is developed for multimodal synergic melanoma therapy promoting wound healing.

Language: Английский

Citations

“Spark” PtMnIr Nanozymes for Electrodynamic‐Boosted Multienzymatic Tumor Immunotherapy DOI

Danyang Li, Enna Ha, Zhenli Zhou

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(13)

Published: Dec. 18, 2023

Abstract Multienzyme‐mimicking redox nanozymes capable of efficient reactive oxygen species (ROS) generation and cellular homeostasis disruption are highly pursued for cancer therapy. However, it still faces challenges from the complicate tumor microenvironment (TME) high chance metastasis. Herein, well‐dispersed PtMnIr designed with multiple enzymatic activities, including catalase (CAT), oxidase (OXD), superoxide dismutase (SOD), peroxidase (POD), glutathione (GPx), which continuously produce ROS deplete (GSH) concurrently in an “inner catalytic loop” way. With help electrodynamic stimulus, active “spark” (Ir 3+ Mn ) significantly increased, resulting effective cascade Moreover, cyclic can also facilitate ferroptosis apoptosis cells, boosting synergistic Importantly, lung metastasis inhibition is found, confirms immunotherapy by combined effect immunogenic cell death (ICD) 2+ ‐induced guanosine monophosphate (GMP)–adenosine (AMP) synthase (cGAS)–stimulator interferon genes (cGAS–STING) pathway, contributing great potential treatment malignant tumors.

Language: Английский

Citations

Inorganic Nanosheet-Shielded Probiotics: A Self-Adaptable Oral Delivery System for Intestinal Disease Treatment DOI

Ya‐Xuan Zhu,

Yanling You,

Zhuo Chen

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(10), P. 4683 - 4692

Published: March 13, 2023

The oral delivery of probiotics is commonly adopted for intestinal disease treatments in clinical settings; however, the suffer from a strong acidic attack gastric area and low-efficiency colonization naked probiotics. Coating living with synthetic materials has proven effective enabling adaption bacteria to gastrointestinal environments, which, unfortunately, may shield initiating therapeutic responses. In this study, we report copolymer-modified two-dimensional H-silicene nanomaterial (termed SiH@TPGS-PEI) that can facilitate adapt diverse microenvironments on-demand. Briefly, SiH@TPGS-PEI electrostatically coated on surface probiotic helps resist erosive destruction stomach spontaneously degrades by reacting water generate hydrogen, an anti-inflammatory gas response neutral/weakly alkaline environment, thus exposing colitis amelioration. This strategy shed new light development intelligent self-adaptive materials.

Language: Английский

Citations

Nanomedicine Strategies in Conquering and Utilizing the Cancer Hypoxia Environment DOI

Yi Pan,

Longcai Liu,

Xiaozhou Mou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 20875 - 20924

Published: Oct. 23, 2023

Cancer with a complex pathological process is major disease to human welfare. Due the imbalance between oxygen (O2) supply and consumption, hypoxia natural characteristic of most solid tumors an important obstacle for cancer therapy, which closely related tumor proliferation, metastasis, invasion. Various strategies exploit feature have been developed in past decade, can be used alleviate hypoxia, or utilize targeted delivery diagnostic imaging. The include delivering O2, situ O2 generation, reprogramming vascular system, decreasing inhibiting HIF-1 pathways. On other side, also utilized hypoxia-responsive chemical construction hypoxia-active prodrug-based strategies. Taking advantage region, number methods applied identify keep track changes hypoxia. Herein, we thoroughly review recent progress nanomedicine both conquering utilizing combat put forward prospect emerging nanomaterials future clinical transformation, hopes provide perspectives design.

Language: Английский

Citations

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy DOI

Mengyue Li, Geng Yang, Yue Zheng

et al.

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: June 10, 2023

Abstract Targeted chemo-phototherapy has received widespread attention in cancer treatment for its advantages reducing the side effects of chemotherapeutics and improving therapeutic effects. However, safe efficient targeted-delivery agents remains a major obstacle. Herein, we successfully constructed an AS1411-functionalized triangle DNA origami (TOA) to codeliver chemotherapeutic drug (doxorubicin, DOX) photosensitizer (indocyanine green, ICG), denoted as TOADI (DOX/ICG-loaded TOA), targeted synergistic chemo-phototherapy. In vitro studies show that AS1411 aptamer nucleolin efficiently enhances nanocarrier’s endocytosis more than 3 times by tumor cells highly expressing nucleolin. Subsequently, controllably releases DOX into nucleus through photothermal effect ICG triggered near-infrared (NIR) laser irradiation, acidic environment lysosomes/endosomes facilitates release. The downregulated Bcl-2 upregulated Bax, Cyt c, cleaved caspase-3 indicate chemo-phototherapeutic induces apoptosis 4T1 cells, causing ~ 80% cell death. tumor-bearing mice, exhibits 2.5-fold accumulation region TODI without AS1411, 4-fold higher free ICG, demonstrating excellent targeting ability vivo. With synergetic shows significant 90% inhibition growth with negligible systemic toxicity. addition, presents outstanding superiority fluorescence imaging. Taken together, this multifunctional origami-based nanosystem specific controllable release provides new strategy enhanced therapy.

Language: Английский

Citations

Poly(Glutamic Acid)-Engineered Nanoplatforms for Enhanced Cancer Phototherapy DOI

Yu Zhang, Yiming Lu, Yicong Li

et al.

Current Drug Delivery, Journal Year: 2023, Volume and Issue: 21(3), P. 326 - 338

Published: Jan. 19, 2023

Phototherapies, including photothermal therapy and photodynamic therapy, have gained booming development over the past several decades for their attractive non-invasiveness nature, negligible adverse effects, minimal systemic toxicity, high spatial selectivity. Phototherapy usually requires three components: light irradiation, photosensitizers, molecular oxygen. Photosensitizers can convert energy into heat or reactive oxygen species, which be used in tumor-killing process. The direct application of photosensitizers tumor is restricted by poor water solubility, fast clearance, severe low cellular uptake. encapsulation nanostructures an strategy to overcome these critical limitations. Poly(glutamic acid) (PGA) a kind poly(amino acid)s containing repeating units glutamic acid. PGA has superiority cancer treatment because its good biocompatibility, immunogenicity, modulated pH responsiveness. hydrophilicity nature allows physical entrapment anticancer drugs via construction amphiphilic polymers. Moreover, pendent carboxyl groups enable chemical conjugation with therapeutic agents. In this mini-review, we highlight stateof- the-art design fabrication PGA-based nanoplatforms phototherapy. We also discuss potential challenges future perspectives phototherapy, clinical translation nanomedicines.

Language: Английский

Citations

Gas-assisted phototherapy for cancer treatment DOI

Jun Zhou, Chen Cao, Xinlu Zhang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 564 - 577

Published: July 14, 2023

Language: Английский

Citations

NIR‐Activatable Heterostructured Nanoadjuvant CoP/NiCoP Executing Lactate Metabolism Interventions for Boosted Photocatalytic Hydrogen Therapy and Photoimmunotherapy DOI

Chunzheng Yang,

Jiashi Zhang,

Mengyu Chang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: Nov. 2, 2023

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic noninvasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits clinical outcomes. Although several metabolic interventions have been devoted ameliorate immunosuppression, intracellular residual LA still remains a potential energy source for oncocyte proliferation. Herein, an immunomodulatory nanoadjuvant based on yolk-shell CoP/NiCoP (CNCP) heterostructure loaded with the monocarboxylate transporter 4 inhibitor fluvastatin sodium (Flu) is constructed concurrently relieve immunosuppression elicit robust antitumor immunity. Under NIR irradiation, CNCP heterojunctions exhibit superior photothermal performance photocatalytic production of reactive oxygen species hydrogen. The continuous heat then facilitates Flu release restrain exudation from tumor cells, whereas cumulative can be depleted as hole scavenger improve efficiency. Subsequently, potentiated therapy not only initiate systematic immunoreaction, but also provoke severe mitochondrial dysfunction disrupt supply shock protein synthesis, in turn realizing mild therapy. Consequently, remodeling endows intensive cascade treatment optimal safety profile effectually suppress proliferation metastasis, which offers new paradigm development metabolism-regulated immunotherapy.

Language: Английский

Citations

Injectable thermosensitive black phosphorus nanosheet- and doxorubicin-loaded hydrogel for synergistic bone tumor photothermal-chemotherapy and osteogenesis enhancement DOI

Shihuai Li,

Yunan Qing,

Yan Lou

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124209 - 124209

Published: March 25, 2023

Language: Английский

Citations