Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158081 - 158081
Published: Nov. 1, 2024
Language: Английский
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12889 - 12937
Published: Dec. 1, 2024
Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,
Language: Английский
Citations
9
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149248 - 149248
Published: Feb. 2, 2024
Language: Английский
Citations
8
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Metal‐protein hybrid materials represent a novel class of functional that exhibit exceptional physicochemical properties and tunable structures, rendering them remarkable applications in diverse fields, including engineering, biocatalysis, biosensing, biomedicine. The design development multifunctional biocompatible metal‐protein have been the subject extensive research key aspiration for practical clinical settings. This review provides comprehensive analysis strategies, intrinsic properties, biomedical these materials, with specific emphasis on their potential cancer therapy, drug vaccine delivery, antibacterial treatments, tissue regeneration. Through rational design, stable can be synthesized using straightforward methods, enabling therapeutic, immunomodulatory, other desired functionalities. Finally, outlines existing limitations challenges associated evaluates translation, providing insights into implementation within applications.
Language: Английский
Citations
1
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101620 - 101620
Published: Feb. 27, 2025
The limited efficacy of radiotherapy (RT) in breast cancer is intricately linked to the hypoxic tumor microenvironment. Delivering catalase (CAT) decompose hydrogen peroxide (H2O2) into oxygen a promising strategy address this. However, challenges such as low transport efficiency, accumulation normal organs, and lack spatiotemporal control hinder its clinical application. To this, we developed an innovative ultrasound-responsive engineered bacteria-based CAT delivery system (UEB), which effectively overcomes these by targeting tumors, ensuring efficient expression, providing precise over H2O2 decomposition. When subjected ultrasound irradiation, decomposition production UEB increased threefold, demonstrating excellent capability alleviating hypoxia. organs was minimized through this strategy. Moreover, bacteria enhance reactive species (ROS) generation, improving RT outcomes significantly inhibiting growth, resulting 10-fold size reduction. This study demonstrates for specific, controlled expression application radiotherapy.
Language: Английский
Citations
1
Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 399, P. 124403 - 124403
Published: March 5, 2024
Ionic liquids (ILs) have a long and successful history of application as materials special interest in various fields, particularly biomedicine. When polymerized at the nanoscale, polymeric ILs (PILs) combine attractive properties with united advantages solid polymer structures nanoparticulate matter. As rapidly developing nanomaterials biomedical importance, they afford new prospects for treatment diseases. In particular, due to their greatly tunable composition, biocompatibility wide specific surface area, PIL nanoparticles offer potential delivery systems different medications. This brief review introduces emerging landscape drug-delivery summarizes actual applications available from recent literature (after 2018). Special attention is paid methods fabricating nano-sized PILs responsible controlled drug release. Critically discussed are diverse examples using nanostructures based on variable morphology designed drug-vehicle vectors. Also brought into focus challenges preclinical development future perspectives nanocarriers.
Language: Английский
Citations
6
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 144, P. 107161 - 107161
Published: Jan. 29, 2024
Language: Английский
Citations
5
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(15), P. 18534 - 18550
Published: April 4, 2024
The metastasis and recurrence of cancer are related to immunosuppression hypoxia in the tumor microenvironment. Activating immune activity improving hypoxic environment face essential challenges. This paper reports on a multifunctional nanomaterial, HSCCMBC, that induces immunogenic cell death through powerful photodynamic therapy/chemodynamic therapy synergistic antitumor effects. microenvironment changed from immunosuppressive type type, activated system, decomposed hydrogen peroxide generate oxygen based Fenton-like reaction, effectively increased level intracellular O2 with assistance 3-bromopyruvate, respiratory inhibitor. structure composition HSCCMBC were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, diffraction, infrared etc. Oxygen probe RDPP was used investigate inside outside cell, hydroxyl radical tetramethylbenzidine reaction ability. immunofluorescence method investigated expression various markers hypoxia-inducing factors vitro vivo after treatment. In experiments indicate is an excellent agent expected be candidate drug for immunotherapy.
Language: Английский
Citations
5
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 23, 2024
Photodynamic therapy and ferroptosis induction have risen as vanguard oncological interventions, distinguished by their precision ability to target vulnerabilities in cancer cells. therapy's non-invasive profile selective cytotoxicity complement ferroptosis' unique mode of action, which exploits iron-dependent lipid peroxidation, offering a pathway overcome chemoresistance with lower systemic impact. The synergism between photodynamic is underscored the depletion glutathione peroxidase four inhibitions therapy-induced reactive oxygen species, amplifying peroxidation enhancing ferroptotic cell death. This synergy presents an opportunity refine treatment modulating redox homeostasis. Porphyrin-based nanoscale metal-organic frameworks hybrid structures exceptional properties. These can serve platform for integrating through carefully designed functions. nanostructures be engineered deliver multiple therapeutic modalities simultaneously, marking pivotal advance multimodal therapy. review synthesizes recent progress porphyrin-modified combined ferroptosis, delineating mechanisms that underlie synergistic effects context. It underscores potential porphyrin-based advanced nanocarriers oncology, propelling field toward more efficacious tailored treatments.
Language: Английский
Citations
5
Chemical Communications, Journal Year: 2024, Volume and Issue: 60(93), P. 13641 - 13652
Published: Jan. 1, 2024
Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.
Language: Английский
Citations
5
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
An oxygen self-supplying nanoplatform utilizing perfluorocarbon-functionalized porphyrinic MOFs was developed to alleviate tumor hypoxia. This strategy combines external oxygen-delivery with in situ generation via cascade reactions, resulting enhanced synergistic effects for both cancer starvation therapy and robust photodynamic therapy.
Language: Английский
Citations
0