Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: April 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 23, 2024
Abstract
Hyaluronic
acid
(HA)
is
a
naturally
occurring
polysaccharide
found
in
the
extracellular
matrix
with
broad
applications
disease
treatment.
HA
possesses
good
biocompatibility,
biodegradability,
and
ability
to
interact
various
cell
surface
receptors.
Its
wide
range
of
molecular
weights
modifiable
chemical
groups
make
it
an
effective
drug
carrier
for
delivery.
Additionally,
overexpression
specific
receptors
on
surfaces
many
states
enhances
accumulation
drugs
at
pathological
sites
through
receptor
binding.
In
this
review,
modification
drugs,
major
proteins,
latest
advances
receptor‐targeted
nano
delivery
systems
(DDS)
treatment
tumors
inflammatory
diseases
are
summarized.
Furthermore,
functions
varying
vivo
selection
methods
different
discussed.
BMEMat,
Journal Year:
2024,
Volume and Issue:
2(2)
Published: Jan. 10, 2024
Abstract
Two‐dimensional
(2D)
nanomaterials,
known
for
their
unique
atomic
arrangements
and
exceptional
physicochemical
properties,
have
garnered
significant
attention
in
biomedical
applications,
particularly
the
realms
of
immunotherapy
tissue
engineering
tumor
therapy.
These
applications
necessitate
a
thorough
assessment
potential
influence
2D
nanomaterials
on
immune
cells.
Notably,
mononuclear
phagocyte
system
(MPS)
cells,
which
play
pivotal
roles
both
innate
adaptive
immunity,
are
essential
maintaining
organismal
homeostasis.
MPS
cells
with
phagocytic
capability
contribute
to
prevention
foreign
body
invasion
elimination
dead
or
senescent
Furthermore,
including
macrophages
dendritic
serve
as
vital
bridges
between
responses.
Therefore,
understanding
nano‐bio
interactions
is
imperative.
cellular
uptake,
cytocompatibility,
immunological
impact
invaluable
purposeful
design
nanomaterials.
Herein,
we
provide
an
overview
latest
advancements
discuss
current
challenges
future
prospects
employing
field
nanomedicine.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(14)
Published: Feb. 4, 2024
Abstract
Sonodynamic
therapy
(SDT),
a
tumor
treatment
modality
with
high
tissue
penetration
and
low
side
effects,
is
able
to
selectively
kill
cells
by
producing
cytotoxic
reactive
oxygen
species
(ROS)
ultrasound‐triggered
sonosensitizers.
N‐type
inorganic
semiconductor
TiO
2
has
ROS
quantum
yields
under
ultrasound
irradiation
inadequate
anti‐tumor
activity.
Herein,
using
atomic
layer
deposition
(ALD)
create
heterojunction
between
porous
CoO
x
,
the
sonodynamic
efficiency
of
can
be
improved.
Compared
conventional
techniques,
controllability
ALD
allows
for
delicate
loading
nanoparticles
into
pores,
resulting
in
precise
tuning
interfaces
energy
band
structures
ultimately
optimal
SDT
properties.
In
addition,
exhibits
cascade
H
O
→O
→·O
−
response
microenvironment,
which
not
only
mitigates
hypoxia
during
process,
but
also
contributes
effect
chemodynamic
(CDT).
Correspondingly,
synergistic
CDT/SDT
successful
inhibiting
growth.
Thus,
provides
new
avenues
catalytic
other
pharmaceutical
applications.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(11), P. 7769 - 7795
Published: Feb. 29, 2024
Tumor-associated
macrophages
(TAMs)
play
pivotal
roles
in
tumor
development.
As
primary
contents
of
environment
(TME),
TAMs
secrete
inflammation-related
substances
to
regulate
tumoral
occurrence
and
There
are
two
kinds
TAMs:
the
tumoricidal
M1-like
protumoral
M2-like
TAMs.
Reprogramming
from
immunosuppressive
M2
immunocompetent
M1
phenotype
is
considered
a
feasible
way
improve
immunotherapeutic
efficiency.
Notably,
nanomaterials
show
great
potential
for
biomedical
fields
due
their
controllable
structures
properties.
many
types
that
exhibit
regulatory
activities
TAMs'
reprogramming.
In
this
review,
recent
progress
nanomaterials-involved
reprogramming
comprehensively
discussed.
The
various
strategies
summarized
introduced.
Additionally,
challenges
perspectives
efficient
therapy
discussed,
aiming
provide
inspiration
regulator
design
promote
development
TAMs-mediated
immunotherapy.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: April 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
