Virus-Inspired Biodegradable Tetrasulfide-Bridged Mesoporous Organosilica with GSH Depletion for Fluorescence Imaging-Guided Sonodynamic Chemotherapy of Glioblastoma Multiforme DOI
Wei Feng, Yanling Lin,

Rujun Pan

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70407 - 70418

Published: Dec. 13, 2024

Glioblastoma multiforme (GBM), a highly prevalent and lethal form of malignant tumor, is typically treated with Temozolomide (TMZ), chemotherapeutic agent. Nevertheless, the effectiveness TMZ hampered by inadequate cell entry, systemic adverse effects, monotherapy constraints. Previous clinical studies have demonstrated that combination therapy can significantly enhance therapeutic efficacy. Herein, we developed ultrasmall virus-inspired biodegradable tetrasulfide-bridged mesoporous organosilica coloaded indocyanine green (ICG) (designated as vMSTI) for fluorescence imaging-guided sonodynamic chemotherapy glutathione (GSH) depletion, aiming to efficiency GBM. Once accumulated within tumors, vMSTI nanosystem efficiently entered tumor cells via "spike surface"-assisted endocytosis. Subsequently, intracellular overproduction GSH triggered degradation vMSTI, resulting in release both ICG, while simultaneously depleting levels. Upon ultrasound (US) irradiation, released ICG generated abundant reactive oxygen species (ROS) therapy, which could be further potentiated depletion. Furthermore, effectively elicited DNA damage enable chemotherapy. Consequently, apoptosis, suppressing GBM growth under guidance imaging. Our nanosystems offered promising strategy

Language: Английский

Emerging Chemodynamic Nanotherapeutics for Cancer Treatment DOI
Dongqi Sun, Xinxin Sun, Xuan Zhang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

Citations

19
Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy DOI

Fuhong Yang,

Jingqi Lv,

Wen Ma

et al.

Small, Journal Year: 2024, Volume and Issue: 20(44)

Published: July 6, 2024

Abstract Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising approach for deep‐seated tumors. However, the general or only utilization of SDT shows efficiency unsatisfactory treatment outcomes due to complicated tumor microenvironment (TME) process. To circumvent issues, three feasible approaches enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies conquering hypoxia TME, combinational are summarized, with particular focus on combination other modalities, chemodynamic therapy, photodynamic photothermal chemotherapy, starvation gas immunotherapy. In end, current challenges in tumors discussed enhanced effects provided. It envisioned that this review will provide new insight into strategic design high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting accelerating potential clinical transformation.

Language: Английский

Citations

14
Precise Design of TiO2@CoOx Heterostructure via Atomic Layer Deposition for Synergistic Sono‐Chemodynamic Oncotherapy DOI Creative Commons
Wen Liu,

Runrun Shao,

Lingyun Guo

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 4, 2024

Abstract Sonodynamic therapy (SDT), a tumor treatment modality with high tissue penetration and low side effects, is able to selectively kill cells by producing cytotoxic reactive oxygen species (ROS) ultrasound‐triggered sonosensitizers. N‐type inorganic semiconductor TiO 2 has ROS quantum yields under ultrasound irradiation inadequate anti‐tumor activity. Herein, using atomic layer deposition (ALD) create heterojunction between porous CoO x , the sonodynamic efficiency of can be improved. Compared conventional techniques, controllability ALD allows for delicate loading nanoparticles into pores, resulting in precise tuning interfaces energy band structures ultimately optimal SDT properties. In addition, exhibits cascade H O →O →·O − response microenvironment, which not only mitigates hypoxia during process, but also contributes effect chemodynamic (CDT). Correspondingly, synergistic CDT/SDT successful inhibiting growth. Thus, provides new avenues catalytic other pharmaceutical applications.

Language: Английский

Citations

13
Ternary Bi2WO6/TiO2–Pt Heterojunction Sonosensitizers for Boosting Sonodynamic Therapy DOI

Shengwu Wen,

Weiyun Zhang,

Jinlong Yang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(34), P. 23672 - 23683

Published: Aug. 13, 2024

Engineering Z-scheme heterojunctions represents a promising strategy for optimizing the separation and migration of charge carriers in semiconductor sonosensitizers enhanced reactive oxygen species (ROS) generation. Nevertheless, establishing continuous directional pathway ultrasonic-induced flow remains significant challenge. In this study, we present ternary Bi

Language: Английский

Citations

11
Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment DOI
Min Zhang, Dandan Sun, Hui Huang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

Citations

10
A novel signal-on photoelectrochemical immunosensor based on anthocyanin-sensitized poly(indole-5-carboxylic acid) for ultrasensitive detection of CEA DOI

Yanmei Cheng,

Jingjing Wang, Zheng Lu

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136681 - 136681

Published: Sept. 1, 2024

Language: Английский

Citations

6
Modification strategies of TiO2-based nanocatalysts for CO2 reduction through photocatalysis: A mini review DOI

Ya‐Nan Jing,

Xing-Liang Yin, Lei-Lei Li

et al.

Applied Catalysis A General, Journal Year: 2024, Volume and Issue: unknown, P. 120054 - 120054

Published: Dec. 1, 2024

Language: Английский

Citations

5
Metastructure and strain-defect engineered Cu-doped TiO coating to enhance antibacterial sonodynamic therapy DOI
Songsong Wang, Ji Tan, Haifeng Zhang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 458 - 473

Published: Feb. 27, 2025

Language: Английский

Citations

0
Advances in Sonodynamic Therapy: Focus on Ferroptosis DOI

Wen‐Qing Su,

Hao Wang,

Juhong Pan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Ferroptosis is a nonapoptotic form of cell death discovered in 2012. Noninvasive treatments regulating ferroptosis are important for wide range diseases. Among the noninvasive treatments, sonodynamic therapy (SDT) has become promising due to its strong tissue penetration and few side effects. In recent years, targeted drug delivery platforms constructed on basis SDT have provided an efficient mode regulation ferroptosis. Based latest research reports, this Perspective introduces basic mechanism influencing factors therapeutic effects, elucidates significance ferroptosis-targeted SDT, summarizes studies through different pathways. We also present innovative composite ultrasound-responsive platforms. Finally, brief summary outlook based current presented.

Language: Английский

Citations

0
pH-driven butterfly effect for cascade-amplified tumor therapy based on thalidomide coordinated Fe-HMME nanoplatform DOI Creative Commons
Botao Qu, Qian Wang, Yuxin Zhou

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101691 - 101691

Published: March 1, 2025

A promising approach for treating intractable cancers has been presented by photodynamic therapy (PDT). However, the limited penetration depth of PDT and suboptimal monotherapy efficacy significantly restrict its clinical applications. In this study, we constructed an acidic tumor microenvironment (TME)-activated carrier-free nanoplatform (HMME-Fe-Thal, abbreviated as HFT) through self-assembly iron ions, photosensitizer hematoporphyrinmonomethyl ether (HMME) anti-angiogenesis drug thalidomide (Thal). Near infrared (NIR) triggers behavior before degradation HFT nanoplatform. Subsequently, degrades, releasing Thal chemotherapy, ions chemodynamic (CDT), which reinforce therapeutic benefits synergistically. Moreover, released turn on MRI signal, can suggest most appropriate time PDT, divide treatment into two stages (First-stage: Second-stage: CDT/chemotherapy), gradually achieve cascade-amplified therapy. sense, modulates TME leads to a "butterfly effect" CDT/chemotherapy/glutathione (GSH) depletion enhanced efficacy. This strategy compensates deficient shadow poor from monotherapy. work presents selection rational design endogenous components regression, greatly push nanomaterials towards development application.

Language: Английский

Citations

0