Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(6), P. 2826 - 2832
Published: Jan. 1, 2024
Bacterial infections are a big challenge in clinical treatment, making it urgent to develop innovative antibacterial systems and therapies combat bacterial infections.
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(17)
Published: Jan. 31, 2023
Antimicrobial resistance (AMR) is one of the biggest threats to environment and health. AMR rapidly invalidates conventional antibiotics, antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several show AMR-independent effects without detectable new therefore suggested prevent evolution. In contrast, some are found trigger evolution AMR. Given these seemingly conflicting findings, a timely discussion two faces urgently needed. This review systematically compares killing mechanisms structure-activity relationships antibiotics nanomaterials. We then focus on nano-microbe interactions elucidate impacts molecular initiating events Finally, we provide an outlook future propose design principles for prevention
Language: Английский
Citations
255
Small, Journal Year: 2023, Volume and Issue: 19(42)
Published: June 15, 2023
With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.
Language: Английский
Citations
67
TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 159, P. 116945 - 116945
Published: Jan. 20, 2023
Language: Английский
Citations
46
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 255 - 255
Published: Feb. 9, 2024
Nanoparticles, especially gold nanoparticles (Au NPs) have gained increasing interest in biomedical applications. Used for disease prevention, diagnosis and therapies, its significant advantages therapeutic efficacy safety been the main target of interest. Its application immune system stability physiological environments cell membranes, low toxicity optimal bioperformances are critical to success engineered nanomaterials. unique optical properties great attractors. Recently, several physical chemical methods coating these NPs widely used. Biomolecules such as DNA, RNA, peptides, antibodies, proteins, carbohydrates biopolymers, among others, used coatings Au various applications, thus their biocompatibility while maintaining biological functions. This review mainly presents a general representative view different types NP functionalization using biomolecules, strategies mechanisms.
Language: Английский
Citations
30
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: 34(4), P. 1417 - 1451
Published: Jan. 9, 2024
Language: Английский
Citations
29
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Nov. 15, 2024
Abstract Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology healthcare while addressing critical aspects safety environmental risks associated with its widespread application. Beginning an introduction to integration we first delved into categorisation various materials employed, setting stage for a comprehensive understanding potential. We then proceeded elucidate diverse applications nanotechnology, spanning medical tissue engineering, targeted gene development antimicrobial agents. The discussion extended current situation surrounding clinical translation commercialisation these cutting-edge technologies, focusing on nanotechnology-based products that have been approved globally date. also discussed considerations nanomaterials, both terms human health impact. presented vivo nanomaterial exposure, relation transport mechanisms, oxidative stress, physical interactions. Moreover, highlighted risks, acknowledging potential implications ecosystems biodiversity. Lastly, strived offer insights regulatory governing across different regions globally. By synthesising perspectives, underscore imperative balancing innovation stewardship, charting path forward responsible healthcare. Graphical abstract
Language: Английский
Citations
26
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: June 25, 2024
Abstract Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for research treatment of infectious diseases. Their applications in realm include pathogen detection, exploration biological mechanisms, development anti‐infective drugs. This review provides a concise introduction severity, classification, pathogenesis Subsequently, we examined distinctiveness design strategies diagnosing treating diseases, shedding light on their rationale using typical examples. We discuss current status associated with clinical implementation probes. Furthermore, explored prospects these diagnosis aims offer novel insights into diagnostic broaden disease treatment.
Language: Английский
Citations
20
ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 19840 - 19872
Published: Nov. 28, 2022
Bacterial infections remain the leading cause of death worldwide today. The emergence antibiotic resistance has urged development alternative antibacterial technologies to complement or replace traditional treatments. In this regard, metal nanomaterials have attracted great attention for their controllable functions that are less prone resistance. This review discusses a particular family stimuli-activable metal-bearing (denoted as SAMNs) and associated on-demand strategies. various SAMN-enabled strategies stem from basic light magnet activation, with addition bacterial microenvironment responsiveness and/or bacteria-targeting selectivity therefore offer higher spatiotemporal controllability. discussion focuses on nanomaterial design principles, mechanisms, performance, well emerging applications desire selective activation (i.e., medical treatments, surface anti-biofilm, water disinfection, wearable materials). concludes authors' perspectives challenges future directions developing industrial translatable next-generation
Language: Английский
Citations
64
Biosensors, Journal Year: 2022, Volume and Issue: 13(1), P. 29 - 29
Published: Dec. 26, 2022
Infectious pathogens cause severe threats to public health due their frightening infectivity and lethal capacity. Rapid accurate detection of is great significance for preventing infection. Gold nanoparticles have drawn considerable attention in colorimetric biosensing during the past decades unique physicochemical properties. Colorimetric diagnosis platforms based on functionalized AuNPs are emerging as a promising pathogen-analysis technique with merits high sensitivity, low-cost, easy operation. This review summarizes recent development this field. We first introduce detecting characteristics gold nanoparticles. Four types strategies, including application indirect target-mediated aggregation, chromogenic substrate-mediated catalytic activity, point-of-care testing (POCT) devices, machine learning-assisted sensor arrays, systematically introduced. In particular, three biomolecule-functionalized AuNP-based sensors described detail. Finally, we conclude by presenting our subjective views present challenges some appropriate suggestions future research directions sensors.
Language: Английский
Citations
47
Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)
Published: July 3, 2023
Abstract Nanozymes capable of generating reactive oxygen species have recently emerged as promising treatments for wounds infected with drug‐resistant bacteria, possessing a reduced possibility inducing resistance. However, the therapeutic effect is limited by shortage endogenous oxy‐substrates and undesirable off‐target biotoxicity. Herein, ferrocenyl coordination polymer (FeCP) nanozyme, featuring pH switchable peroxidase (POD)‐ catalase (CAT)‐like activity incorporated indocyanine green (ICG) calcium peroxide (CaO 2 ) to fabricate an H O /O self‐supplying system (FeCP/ICG@CaO precise treatment bacterial infections. At wound site, CaO reacts water generate . Acting POD mimic under acidic microenvironment, FeCP catalyzes into hydroxyl radicals prevent infection. switches CAT‐like in neutral tissue, decomposing oxidative damage facilitate healing. Additionally, FeCP/ICG@CaO shows photothermal therapy capability, ICG can emit heat near‐infrared laser irradiation. This assists fully exerting its enzyme‐like activity. Thus, this achieves antibacterial efficiency 99.8% vitro effectively overcomes main limitations nanozyme‐based assays, resulting satisfactory effects repairing normal special skin tumor bacteria.
Language: Английский
Citations
23