Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection

Biomaterials Science, Journal Year: 2022, Volume and Issue: 11(2), P. 432 - 444

Published: Dec. 6, 2022

The barrier function of host cells enables intracellular bacteria to evade the lethality immune system and antibiotics, thereby causing chronic recurrent infections that seriously threaten human health. Currently, main clinical strategy for treatment bacterial involves use long-term high-dose antibiotics. However, insufficient delivery antibiotics along with various resistance mechanisms not only weakens efficacy current therapies but also causes serious adverse drug reactions, further increasing disease economic burden. Improving efficiency, accumulation, action time remains most economical effective way treat infections. rapid development nanotechnology provides a efficiently deliver against into cells. In this review, we summarize types common pathogens, difficulties faced by in infections, research progress several representative nanocarriers have emerged recent years. This review is expected provide reference elucidating transport mechanism nanocarrier-drug complexes, designing safer more establishing new strategies infection.

Language: Английский

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Synthesis of ZnO/Au Nanocomposite for Antibacterial Applications

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(21), P. 3832 - 3832

Published: Oct. 30, 2022

Annually, antimicrobial-resistant infections-related mortality worldwide accelerates due to the increased use of antibiotics during coronavirus pandemic and antimicrobial resistance, which grows exponentially, disproportionately current rate development new antibiotics. Nanoparticles can be an alternative therapeutic approach against multi-drug resistance microorganisms caused infections. The motivation behind this work was find a superior antibacterial nanomaterial, efficient, biocompatible, stable in time. This study evaluated activity ZnO-based nanomaterials with different morphologies, synthesized through solvothermal method further modified Au nanoparticles wet chemical reduction. structure, crystallinity, morphology ZnO ZnO/Au have been investigated XRD, SEM, TEM, DLS, FTIR spectroscopy. effect unmodified Escherichia coli Staphylococcus aureus disc diffusion tetrazolium/formazan (TTC) assays. results showed that proposed exhibited significant effects on Gram-positive Gram-negative bacteria. Furthermore, nanorods diameters smaller than 50 nm better larger dimensions. efficiency improved considerably by adding 0.2% (w/w) nanorods. indicated materials’ potential for applications.

Language: Английский

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DNA‐Dependent Prussian Blue Nanoflowers for Biosensing, Catalysis and Imaging

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(4)

Published: Dec. 1, 2022

Abstract While shapes and surface properties of nanomaterials are known to play important roles in defining their properties, it remains challenging fine‐tune the morphologies systematically predictably. Considering extraordinary performance, prussian blue nanoparticles (PBNPs) selected as proof‐of‐concept nanomaterials. Herein, a DNA‐dependence approach fine‐control morphology PBNPs via electrostatic interaction‐mediated self‐assembly inorganic ions protonated DNA is developed. The regulation different on investigated. 30‐mer Oligo‐C or ‐T (C30/T30) mediates formation flower‐like (PB nanoflowers), whereas cubic structure with sizes observed presence 10‐mer oligo‐G Oligo‐A (G10/A30). Detailed mechanism studies indicate that protonation nucleobases key factor for morphological evolution. C30‐dependent PB nanoflowers superior nanocubes photothermal peroxidase mimetic activity, photo‐Fenton catalytic light scattering property, which present 1.2‐, 3.78‐, 1.58‐, 1.93‐fold improvement, respectively. Furthermore, mediated by diblock (sDNA; comprising C30 complementary strands target DNA) unexpectedly acquire biorecognition capabilities. This study opens new avenue systematic predictable synthesis nanoflowers, broadens repertoire catalysis, biosensing, imaging.

Language: Английский

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In the View of Electrons Transfer and Energy Conversion: The Antimicrobial Activity and Cytotoxicity of Metal‐Based Nanomaterials and Their Applications

Small, Journal Year: 2023, Volume and Issue: 20(4)

Published: Sept. 18, 2023

Abstract The global pandemic and excessive use of antibiotics have raised concerns about environmental health, efforts are being made to develop alternative bactericidal agents for disinfection. Metal‐based nanomaterials their derivatives emerged as promising candidates antibacterial due broad‐spectrum activity, friendliness, excellent biocompatibility. However, the reported mechanisms these materials complex lack a comprehensive understanding from coherent perspective. To address this issue, new perspective is proposed in review demonstrate toxic activities metal‐based terms energy conversion electron transfer. First, antimicrobial different discussed, advanced research progresses summarized. Then, biological intelligence applications materials, such biomedical implants, stimuli‐responsive electronic devices, monitoring, concluded based on trappable electrical signals Finally, current improvement strategies, future challenges, possible resolutions outlined provide insights into behaviors offer valuable inspiration instructional suggestions building intelligent health.

Language: Английский

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pH-responsive on-demand release of eugenol from metal–organic frameworks for synergistic bacterial killing

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(6), P. 2826 - 2832

Published: Jan. 1, 2024

Bacterial infections are a big challenge in clinical treatment, making it urgent to develop innovative antibacterial systems and therapies combat bacterial infections.

Language: Английский

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