Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(7), P. 2266 - 2276
Published: Jan. 1, 2023
Although
the
main
function
of
skin
is
to
act
as
a
protective
barrier
against
external
factors,
it
indeed
an
extremely
vulnerable
tissue.
Skincare,
regardless
wound
type,
requires
effective
treatments
prevent
bacterial
infection
and
local
inflammation.
The
complex
biological
roles
displayed
by
hyaluronic
acid
(HA)
during
healing
process
have
made
this
multifaceted
polysaccharide
alternative
biomaterial
prepare
dressings.
Therefore,
herein,
we
present
most
advanced
research
undertaken
engineer
conductive
interactive
hydrogels
based
on
HA
dressings
that
enhance
tissue
regeneration
either
through
electrical
stimulation
(ES)
or
displaying
multifunctional
performance.
First,
briefly
introduce
reader
effect
ES
promoting
why
has
become
vogue
agent.
Then,
selection
systems,
chosen
according
their
relevance,
presented.
Special
care
been
taken
highlight
those
recently
reported
works
(mainly
from
last
3
years)
with
enhanced
scalability
biomimicry.
By
doing
that,
turned
critical
eye
field
considering
what
major
challenges
must
be
overcome
for
these
systems
real
commercial,
clinical,
other
translational
impact.
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(7), P. 1787 - 1830
Published: May 26, 2023
Due
to
the
good
reliability
and
long-term
stability,
self-healing
hydrogels
have
emerged
as
promising
soft
materials
for
tissue
engineering,
smart
wearable
sensors,
bioelectronics,
energy
storage
devices.
The
mechanism
depends
on
reversible
chemical
or
physical
cross-linking
interactions.
Self-healing
with
fascinating
features
(including
mechanical
performances,
biocompatibility,
conductivity,
antibacterial
ability,
responsiveness,
etc.)
are
being
designed
developed
according
practical
application
requirements.
In
this
review,
recent
progress
in
their
synthesis
strategies
multiple
applications
is
summarized.
Their
involve
processes
a
combination
of
two.
include
flexible
strain
supercapacitors,
actuators,
adhesives,
wound
healing,
drug
delivery,
tumor
treatment,
3D
printing,
etc.
Finally,
current
challenges,
future
development,
opportunities
discussed.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(14), P. 17562 - 17576
Published: March 6, 2023
Bioactive
hydrogels
self-assembled
from
naturally
occurring
herbal
small
molecules
are
attracting
growing
interest
for
applications
in
wound
healing,
due
to
their
versatile
intrinsic
biological
activities,
excellent
biocompatibility,
as
well
facile,
sustainable,
and
eco-friendly
processes.
However,
the
development
of
supramolecular
herb
with
sufficient
strength
multifunctionality
an
ideal
dressing
clinical
practice
remains
a
challenge.
In
this
work,
inspired
by
efficient
clinic
therapy
directed
self-assembly
natural
saponin
glycyrrhizic
acid
(GA),
we
create
novel
GA-based
hybrid
hydrogel
promote
full-thickness
healing
bacterial-infected
healing.
This
possesses
stability
mechanical
performance
multifunctional
properties,
including
injectable,
shape-adaptation
remodeling,
self-healing,
adhesive
abilities.
is
attributed
hierarchical
dual-network
that
comprises
hydrogen-bond
fibrillar
network
aldehyde-contained
GA
(AGA)
dynamic
covalent
through
Schiff
base
reaction
between
AGA
biopolymer
carboxymethyl
chitosan
(CMC).
Notably,
benefiting
inherent
strong
activity
GA,
AGA-CMC
exhibits
unique
significant
anti-inflammation
effects
antibacterial
ability,
especially
toward
Gram-positive
Staphylococcus
aureus
(S.
aureus).
vivo
experiments
demonstrate
promotes
uninfected
skin
S.
aureus-infected
enhancing
formation
granulation
tissue,
facilitating
collagen
deposition,
reducing
bacterial
infection,
downregulating
inflammatory
response.
study
highlights
design
new
bioactive
drug-food
homologous
molecules,
which
can
serve
promising
wound-healing
biomedical
applications.
Journal of Tissue Engineering,
Journal Year:
2023,
Volume and Issue:
14
Published: Jan. 1, 2023
Scars
caused
by
skin
injuries
after
burns,
wounds,
abrasions
and
operations
have
serious
physical
psychological
effects
on
patients.
In
recent
years,
the
research
of
scar
free
wound
repair
has
been
greatly
expanded.
However,
understanding
complex
mechanisms
healing,
in
which
various
cells,
cytokines
mechanical
force
interact,
is
critical
to
developing
a
treatment
that
can
achieve
scarless
healing.
Therefore,
this
paper
reviews
types
mechanism
formation
healing
process,
current
progress
dual
consideration
prevention,
some
strategies
for
repair.
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(12), P. 3142 - 3155
Published: Oct. 27, 2023
Antibacterial,
anti-inflammatory,
and
healing-promoting
treatment
of
chronically
infected
wounds
is
not
only
clinical
problems
to
be
solved
urgently
but
also
important
needs
related
people's
livelihood.
However,
multifunctional
hydrogel
dressings
with
highly
efficient
antibacterial,
wound
microenvironment
sensitive
drug
release
performance
still
remain
a
challenge.
In
this
work,
dressing
was
achieved
by
introducing
mussel-like
super
adhesion
catechol
groups
glucose/ROS-sensitive
dynamic
phenylboronester
bond
cross-linking
network,
which
endowed
the
excellent
injectable,
self-healing,
tissue
properties,
performance.
Additionally,
high-efficiency
photothermal
synergistic
antibacterial
TP@Ag
NPs
were
prepared
introduced
into
hydrogel.
The
glucose/ROS
responsive
borate
in
network
could
realize
NPs,
thereby
promoting
M2
polarization
achieve
an
anti-inflammatory
effect.
And
excess
reactive
oxygen
(ROS)
scavenged
effect
group
ROS-sensitive
Moreover,
biocompatibility
antioxidant
shown
hydrogels.
Finally,
fully
fill
adhere
irregular
through
injection
significantly
promote
diabetic
healing
vivo
sterilization,
ROS
scavenging
ability,
modulation
macrophage
reduce
inflammatory
response.
Thus,
it
illustrated
superiority
as
advanced
functional
for
healing.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2000 - 2000
Published: April 23, 2023
One
of
the
most
advanced,
promising,
and
commercially
viable
research
issues
in
world
hydrogel
dressing
is
gaining
functionality
to
achieve
improved
therapeutic
impact
or
even
intelligent
wound
repair.
In
addition
merits
ordinary
dressings,
functional
dressings
can
adjust
their
chemical/physical
properties
satisfy
different
types,
carry
out
corresponding
reactions
actively
create
a
healing
environment
conducive
repair,
also
control
drug
release
provide
long-lasting
benefit.
Although
lot
in-depth
has
been
conducted
over
last
few
decades,
very
studies
have
properly
summarized.
order
give
researchers
basic
blueprint
for
designing
motivate
them
develop
ever-more
we
summarized
development
recent
years,
as
well
current
situation
future
trends,
light
preparation
mechanisms
effects.
