International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135838 - 135838
Published: Sept. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135838 - 135838
Published: Sept. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 248, P. 125949 - 125949
Published: July 24, 2023
Language: Английский
Citations
47International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130741 - 130741
Published: March 7, 2024
Language: Английский
Citations
28Small, Journal Year: 2024, Volume and Issue: 20(34)
Published: April 9, 2024
Abstract Bacterial infections and inflammation progression yield huge trouble for the management of serious skin wounds burns. However, some hydrogel dressing exhibit poor wound‐healing capabilities. Additionally, little information is given on molecular theory gelation mechanisms drug release performance from drug‐polymer network in water environment. Herein, cationic guar gum (CG) first mixed with dipotassium glycyrrhizinate (DG), then crosslinked Cu 2+ to strengthen mechanical strength followed by encapsulating mussel adhesive protein (MAP) as composite dressings. Intriguingly, CG‐Cu 0.5 ‐DG 10 possessed proper rheological properties predominantly driven strong CG‐H 2 O‐Cu ‐CG hydrogen bonding interaction. Weak DG‐CG only controlled DG initial 4 h, while main force regulating sustained within 48 h. The incorporation MAP further loosened tight crosslinking 10. screened /MAP excellent self‐healing, injectability, antibacterial, anti‐inflammatory, cell proliferation‐promotion activities high biocompatibility. Therefore, expedited wound closure S. aureus ‐infected full‐thickness model lowered necrosis unburned interspaces a rat burn model. results highlight promising translational potential ‐inspired hydrogels burns infected wounds.
Language: Английский
Citations
21International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140328 - 140328
Published: Jan. 1, 2025
Language: Английский
Citations
2Food Chemistry, Journal Year: 2023, Volume and Issue: 437, P. 137891 - 137891
Published: Oct. 29, 2023
Language: Английский
Citations
33Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(8)
Published: Nov. 6, 2023
Effectively controlling bacterial infection, reducing the inflammation and promoting vascular regeneration are all essential strategies for wound repair. Nanozyme technology has potential applications in treatment of infections because its non-antibiotic dependent, topical noninvasive nature. In management, copper-based nanozymes have emerged as viable alternatives to antibiotics. this study, an ultrasmall cupric enzyme with high enzymatic activity is synthesized added a nontoxic, self-healing, injectable cationic guar gum (CG) hydrogel network. The nanozyme exhibits remarkable antioxidant properties under neutral conditions, effectively scavenging reactive nitrogen oxygen species (RNOS). Under acidic Cu NDs peroxide (POD) enzyme-like activity, which allows them eliminate hydrogen peroxides produce free radicals locally. Antibacterial experiments show that they can kill bacteria remove biofilms. It reveals low concentrations ND/CG decrease expression inflammatory factors cells tissues, responses. hydrogels also inhibit HIF-1α promote VEGF ability regeneration. vivo safety assessments reveal favorable biosafety profile. offer promising solution treating acute infected wounds, highlighting innovative nanomaterials healing.
Language: Английский
Citations
33Desalination, Journal Year: 2023, Volume and Issue: 570, P. 117064 - 117064
Published: Oct. 17, 2023
Language: Английский
Citations
28International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129718 - 129718
Published: Jan. 30, 2024
Language: Английский
Citations
15Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216093 - 216093
Published: July 25, 2024
Language: Английский
Citations
12Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122009 - 122009
Published: March 5, 2024
Language: Английский
Citations
11