Nanomaterial-mediated modulation of the cGAS-STING signaling pathway for enhanced cancer immunotherapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 176, P. 51 - 76

Published: Jan. 17, 2024

Language: Английский

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Tumor Microenvironment-Responsive Drug Delivery Based on Polymeric Micelles for Precision Cancer Therapy: Strategies and Prospects

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 417 - 417

Published: Feb. 11, 2024

In clinical practice, drug therapy for cancer is still limited by its inefficiency and high toxicity. For precision therapy, various delivery systems, including polymeric micelles self-assembled from amphiphilic materials, have been developed to achieve tumor-targeting delivery. Considering the characteristics of pathophysiological environment at target site, design, synthesis, or modification environmentally responsive materials has become a crucial strategy drug-targeted comparison normal physiological environment, tumors possess unique microenvironment, characterized low pH, reactive oxygen species concentration, hypoxia, distinct enzyme providing stimuli design micelles. Polymeric with tumor microenvironment (TME)-responsive shown significant improvement in treatment. This review mainly outlines most promising strategies available exploiting construct internal stimulus-responsive that enhanced antitumor efficacy. addition, prospects TME-responsive gene immunotherapy, popular current treatments, are also discussed. via will be an efficient robust approach developing therapies future.

Language: Английский

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CXCR4-Targeted Macrophage-Derived Biomimetic Hybrid Vesicle Nanoplatform for Enhanced Cancer Therapy through Codelivery of Manganese and Doxorubicin

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(14), P. 17129 - 17144

Published: March 27, 2024

Immune-cell-derived membranes have garnered significant attention as innovative delivery modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and superior biocompatibilities. Integrating additional parental cell or synthetic lipid vesicles into cellular can further potentiate capacities to perform combinatorial pharmacological activities activating antitumor immunity, thus providing insights the potential of hybrid versatile vehicles immunotherapy. Here, we developed a macrophage-membrane-derived vesicle that has dual functions transporting immunotherapeutic drugs shaping polarization tumor-associated macrophages The platform combines M1 with CXCR4-binding-peptide-conjugated liposomes loaded manganese doxorubicin. nanovesicles exhibited remarkable macrophage-targeting capacity through CXCR4-binding peptide, resulting enhanced macrophage antitumoral phenotype characterized by proinflammatory cytokine release. manganese/doxorubicin-loaded CXCR4-expressing tumor cells evoked potent cytotoxicity, immunogenic death cells, STING activation. Moreover, cotreatment doxorubicin promoted dendritic maturation, enabling effective growth inhibition. In murine models CT26 colon carcinoma 4T1 breast cancer, intravenous administration elicited robust tumor-suppressing activity at low dosage without adverse systemic effects. Local also induced an abscessive effect bilateral model. This study demonstrates promising biomimetic manganese/doxorubicin-based nanovesicle tailored microenvironment, which may offer approach

Language: Английский

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A Cancer Nanovaccine Based on an FeAl-Layered Double Hydroxide Framework for Reactive Oxygen Species-Augmented Metalloimmunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8143 - 8156

Published: March 4, 2024

The complexity and heterogeneity of individual tumors have hindered the efficacy existing therapeutic cancer vaccines, sparking intensive interest in development more effective situ vaccines. Herein, we introduce a nanovaccine for reactive oxygen species-augmented metalloimmunotherapy which FeAl-layered double hydroxide (LDH) is used as delivery vehicle with dihydroartemisinin (DHA) cargo. LDH framework acid-labile can be degraded tumor microenvironment, releasing iron ions, aluminum DHA. ions contribute to aggravated intratumoral oxidative stress injury by synergistic Fenton reaction DHA activation, causing apoptosis, ferroptosis, immunogenic cell death cells. subsequently released tumor-associated antigens adjuvant form generate robust long-term immune responses against recurrence metastasis. Moreover, Fe ion-enabled T1-weighted magnetic resonance imaging facilitate real-time therapy monitoring. This cancer-nanovaccine-mediated strategy has potential revolutionizing precision immunotherapy landscape.

Language: Английский

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Polydopamine nanoparticles cross-linked hyaluronic acid photothermal hydrogel with cascading immunoinducible effects for in situ antitumor vaccination

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 132177 - 132177

Published: May 9, 2024

Language: Английский

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