Polyoxometalate‐Nanozyme‐Integrated Nanomotors (POMotors) for Self‐Propulsion‐Promoted Synergistic Photothermal‐Catalytic Tumor Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(6)

Published: Dec. 20, 2023

Enzyme-powered nanomotors have demonstrated promising potential in biomedical applications, especially for catalytic tumor therapy, owing to their ability of self-propulsion and bio-catalysis. However, the fragility natural enzymes limits environmental adaptability also therapeutic efficacy catalysis-enabled therapy. Herein, polyoxometalate-nanozyme-based light-driven were designed synthesized targeted synergistic photothermal-catalytic In this construct, peroxidase-like activity P

Language: Английский

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Microrobots for Biomedicine: Unsolved Challenges and Opportunities for Translation

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14196 - 14204

Published: July 26, 2023

Microrobots are being explored for biomedical applications, such as drug delivery, biological cargo transport, and minimally invasive surgery. However, current efforts largely focus on proof-of-concept studies with nontranslatable materials through a "design-and-apply" approach, limiting the potential clinical adaptation. While these have been key to advancing microrobot technologies, we believe that distinguishing capabilities of microrobots will be most readily brought patient bedsides "design-by-problem" which involves focusing unsolved problems inform design practical capabilities. As outlined below, propose translation accelerated by judicious choice target improved delivery considerations, rational selection translation-ready biomaterials, ultimately reducing burden enhancing efficacy therapeutic drugs difficult-to-treat diseases.

Language: Английский

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Swarms of Enzyme‐Powered Nanomotors Enhance the Diffusion of Macromolecules in Viscous Media

Small, Journal Year: 2024, Volume and Issue: 20(11)

Published: Jan. 10, 2024

Abstract Over the past decades, development of nanoparticles (NPs) to increase efficiency clinical treatments has been subject intense research. Yet, most NPs have reported possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in joints mainly composed hyaluronic acid (HA). These viscous media pose a challenge for many applications nanomedicine, passive tend become trapped complex networks, which reduces ability reach target location. This problem can be addressed using active (nanomotors, NMs) that are self‐propelled enzymatic reactions, although enzyme‐powered NMs, capable navigating these environments, remains considerable challenge. Here, synergistic effects two NMs troops, namely hyaluronidase (HyaNMs, Troop 1) and urease (UrNMs, 2) demonstrated. 1 interacts with SF reducing its viscosity, thus allowing 2 swim more easily through SF. Through collective motion, increases diffusion macromolecules. results pave way widespread use e.g., treating joint injuries improving therapeutic effectiveness compared traditional methods.

Language: Английский

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Catalase-Powered Nanobots for Overcoming the Mucus Barrier

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16701 - 16714

Published: June 17, 2024

Biological barriers present a significant obstacle to treatment, especially when drugs are administered locally increase their concentrations at the target site while minimizing unintended off-target effects. Among these barriers, mucus presents challenge, as it serves protective layer in respiratory, urogenital, and gastrointestinal tracts. Its role is shield underlying epithelial cells from pathogens toxic compounds but also impedes efficient delivery of drugs. Despite exploration mucolytic agents improve drug delivery, overcoming this barrier remains hurdle. In our study, we investigate an alternative approach involving use catalase-powered nanobots. We vitro model that simulates intestinal secretion demonstrate dual functionality This includes ability disrupt mucus, which confirmed through ex vivo validation, well self-propulsion overcome barrier, resulting 60-fold compared with passive nanoparticles. Therefore, findings highlight potential utility nanobots carriers for therapeutic since they could enhance efficiency by penetrating barrier.

Language: Английский

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Strategic Assessment of Boron-Enriched Carbon Dots/Naproxen: Diagnostic, Toxicity, and In Vivo Therapeutic Evaluation

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(2), P. 801 - 812

Published: Jan. 13, 2024

Cancer is a significant global public health concern, ranking as the leading cause of mortality worldwide. This study thoroughly explores boron-doped carbon dots (B-CDs) through simple/rapid microwave-assisted approach and their versatile applications in cancer therapy. The result was highly uniform particles with an average diameter approximately 4 nm. B-CDs exhibited notable properties, including strong fluorescence quantum yield 33%. Colloid stability tests revealed robustness within pH range 6–12, NaCl concentrations up to 0.5 M, temperatures ranging from 30 60 °C. also delved into kinetics naproxen release drug delivery system. loading efficacy exceeded 55.56%. Under varying conditions, conformed Peppas–Sahlin model, demonstrating potential Naproxen-loaded CDs for delivery. In vitro cytotoxicity assessments, conducted using CCK-8 Assay flow cytometry, consistently indicated low toxicity cell viability exceeding 80%. An vivo test on female mice administered 20 mg/kg 31 days reversible histological changes liver kidneys, while pancreas remained unaffected. Importantly, did not impact mice's physical behavior, body weight, or survival. experiments targeting benzo(a)pyrene-induced fibrosarcoma demonstrated carriers treatment cancer. provides thorough comprehension synthesis therapy systems.

Language: Английский

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Precision Engineering of Nanorobots: Toward Single Atom Decoration and Defect Control for Enhanced Microplastic Capture

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 15, 2024

Abstract Nanorobots are being received with a great attention for their move‐sense‐and‐act capabilities that often originate from catalytic decomposition of fuels. In the past decade, single‐atom engineering has demonstrated exceptional efficiency in catalysis, energy‐related technologies, and medicine. Here, novel approach involving point defect incorporation platinum (Pt) single atoms atomic level species onto surface titanium dioxide nanotubes (TiO 2 ‐NT)‐based nanorobots is presented its impact on propulsion resulting investigated. The achievement realized through annealing TiO ‐NT hydrogen atmosphere yielding to point‐defect decorated nanotube ‐HNT) nanorobots. Subsequently, Pt ‐SA‐NT) achieved wet‐chemical deposition process. Whereas ‐SA‐NT showed highest negative photogravitaxis when irradiated ultraviolet (UV) light, ‐HNT reached velocity calculated 2D. Both pronounced affinity microplastics, exhibiting capability irreversibly capture them. This pioneering utilizing nanorobotics anticipated pave way highly efficient solutions remediation nano‐ microplastics related environmental technologies.

Language: Английский

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Enzymatic micro/nanomotors in biomedicine: from single motors to swarms

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(11), P. 2711 - 2719

Published: Jan. 1, 2024

Micro/nanomotors (MNMs) have evolved from single self-propelled entities to versatile systems capable of performing one or multiple biomedical tasks. When MNMs self-assemble into coordinated swarms, either under external control triggered by chemical reactions, they offer advantages that individual cannot achieve. These benefits include intelligent multitasking and adaptability changes in the surrounding environment. Here, we provide our perspective on evolution MNMs, beginning with development enzymatic since first theoretical model was proposed 2005. hold immense promise biomedicine due their biocompatibility fuel availability. Subsequently, introduce design application motors biomedicine, followed MNM swarms applications. In end, propose viable solutions for advancing anticipate valuable insights creation more controllable

Language: Английский

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Application of Magnetic Micro/Nanomotors in Biomedicine

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(6), P. 5745 - 5760

Published: March 4, 2024

Micro/nanomotors can convert different forms of energy into mechanical motion according to the controllable direction by mechanisms. This new nanodevice is widely used in biomedical applications such as targeted drug delivery, biological imaging, diagnosis, and detection. Although practical medical these small devices are still initial stage, nanomotors manifest their great potential applications. In particular, micro/nanomotors driven magnetic force have advantages biomedicine because movement direction. this review, classified, recent medicine reviewed. Finally, problems existing possibilities for future development discussed.

Language: Английский

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Nanogel-based nitric oxide-driven nanomotor for deep tissue penetration and enhanced tumor therapy

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 59 - 68

Published: June 14, 2024

Antitumor agents often lack effective penetration and accumulation to achieve high therapeutic efficacy in treating solid tumors. Nanomotor-based nanomaterials offer a potential solution address this obstacle. Among them, nitric oxide (NO) based nanomotors have garnered attention for their applications nanomedicine. However, there widespread clinical adoption has been hindered by complex preparation processes. To limitation, we developed NO-driven nanomotor utilizing convenient scalable nanogel procedure. These nanomotors, loaded with the fluorescent probe / sonosensitizer chlorin e6 (Ce6), were specifically engineered sonodynamic therapy. Through comprehensive vitro investigations using both 2D 3D cell models, as well vivo analysis of Ce6 signal distribution tumor observed that self-propulsion these significantly enhances cellular uptake penetration, particularly This phenomenon enables efficient access challenging regions and, some cases, results complete coverage. Notably, our demonstrated long-term biosafety. study presents an approach enhancing drug improving treatment, relevance future applications.

Language: Английский

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Biomedical Micro/nanomotors: Driven mechanism, preparation and physiological barriers breakthrough

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216441 - 216441

Published: Feb. 4, 2025

Language: Английский

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