Bioinspired polydopamine hydrogels: Strategies and applications

Progress in Polymer Science, Journal Year: 2023, Volume and Issue: 146, P. 101740 - 101740

Published: Sept. 17, 2023

Language: Английский

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Motion artefact management for soft bioelectronics

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(7), P. 541 - 558

Published: April 15, 2024

Language: Английский

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An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 6, 2024

Abstract Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among diabetics, often do not respond well to generalized treatment strategies. Hypoxia the overexpression of reactive oxygen species (ROS), resulting in inflammatory dysregulation subsequent imbalance macrophage phenotypes, are critical factors contributing prolonged non‐healing DFU wounds. These two issues interact continuous, problematic cycle. Presently, there is lack comprehensive strategies aimed at addressing both these simultaneously interrupt this detrimental Herein, an immunomodulatory hydrogel (PHG2) developed for reshaping hostile microenvironment. The engineered PHG2 only removes excess internally‐produced ROS but also generates O 2 , with its efficiency further boosted by local hyperthermia (42.5 °C) activated near‐infrared light. Through vitro vivo studies, along transcriptomic assessment, it confirmed that disrupts feedback loop between inflammation while lowering M1/M2 ratio. Such discoveries contribute significant enhancement healing process injuries undergo gradual increase movement, covering wounds from back, mouth, foot. Ultimately, method provides easy, safe, highly effective solution treating DFUs.

Language: Английский

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Injectable Self‐Expanding/Self‐Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(15)

Published: Nov. 16, 2023

Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and expand stop lethal and/or noncompressible in civil battlefield environments remains a challenge. Herein, an injectable, antibacterial, self-expanding, self-propelling hydrogel bioadhesive with procoagulant activity rapid gelation is reported. This combines spontaneous gas foaming Schiff base crosslinking for massive hemorrhage. Hydrogels have expansion rate, high self-expanding ratio, excellent antibacterial activity, antioxidant efficiency, tissue adhesion capacity. In addition, good cytocompatibility, ability, higher blood cell/platelet than commercial combat gauze gelatin sponge. The optimized (OD-C/QGQL-A30) exhibits better hemostatic ability sponge rat liver femoral artery models, rabbit volumetric loss models with/without anticoagulant, kidney incision site not visible. Especially, OD-C/QGQL-A30 rapidly stops the bleedings from pelvic area of rabbit, swine subclavian vein transection. Furthermore, has biodegradability biocompatibility, accelerates Methicillin-resistant S. aureus (MRSA)-infected skin wound healing. opens up new avenue develop hemostats bleeding, abdominal organ coagulation lesions.

Language: Английский

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A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547

Published: May 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Language: Английский

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Wet‐Adaptive Electronic Skin

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(49)

Published: Aug. 11, 2023

Skin electronics provides remarkable opportunities for non-invasive and long-term monitoring of a wide variety biophysical physiological signals that are closely related to health, medicine, human-machine interactions. Nevertheless, conventional skin fabricated on elastic thin films difficult adapt the wet microenvironments skin: Elastic non-permeable, which block perspiration; adhere skin; Most work underwater. Here, Wet-Adaptive Electronic (WADE-skin) is reported, consists next-to-skin wet-adhesive fibrous layer, next-to-air waterproof stretchable permeable liquid metal electrode layer. While electronic functionality determined by design, this WADE-skin simultaneously offers superb stretchability, adhesion, permeability, biocompatibility, property. The can rapidly human after contact few seconds stably maintain adhesion over weeks even under conditions, without showing any negative effect health. use demonstrated stable recording electrocardiogram during intensive sweating as well underwater activities, strain sensor operation virtual reality-mediated

Language: Английский

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Conductive hydrogels for bioenergy harvesting and self-powered application

Progress in Materials Science, Journal Year: 2023, Volume and Issue: 138, P. 101156 - 101156

Published: June 23, 2023

Language: Английский

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Tissue‐Adhesive Piezoelectric Soft Sensor for In Vivo Blood Pressure Monitoring During Surgical Operation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(38)

Published: May 24, 2023

Abstract The reliable function in vivo of self‐powered implantable bioelectric devices (iBEDs) requires biocompatible, seamless, effective interactions with biological tissues. Herein, an tissue‐adhesive piezoelectric soft sensor (TPSS), which the converts biomechanical signals into electrical signals, and adhesive hydrogel (AH) strengthens this conversion by seamlessly adhering on wet curvilinear surface, is proposed. optimized AH exhibits strong adhesion to various organic or inorganic surfaces, including six commonly used engineering materials three As a pressure sensor, TPSS proves good vitro performance high output 8.3 V, long‐term stability over 6000 cycles, energy power density 186.9 µW m −2 . In large animal experiment, adheres right‐side internal carotid artery Yorkshire pig monitor blood during surgical operation. Compared commercial sensors that work inserting tissues, does not cause any damage can be peeled off after service. integration enables more efficient between system iBEDs, also contributes next‐generation bioelectronics features battery‐free, intelligent, accurate.

Language: Английский

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Water‐Induced Phase Separation for Anti‐Swelling Hydrogel Adhesives in Underwater Soft Electronics

Advanced Science, Journal Year: 2023, Volume and Issue: 10(32)

Published: Sept. 26, 2023

Abstract The development of hydrogel‐based underwater electronics has gained significant attention due to their flexibility and portability compared conventional rigid devices. However, common hydrogels face challenges such as swelling poor adhesion, limiting practicality in water environments. Here, a water‐induced phase separation strategy fabricate with enhanced anti‐swelling properties adhesion is presented. By leveraging the contrasting affinity different polymer chains water, phase‐separated structure rich hydrophobic dilute hydrophilic phases achieved. This dual‐phase structure, meticulously characterized from macroscopic nanoscale, confers hydrogel network augmented retractive elastic forces facilitates efficient drainage at gel‐substrate interface. As result, exhibits remarkable resistance long‐lasting diverse substrates. Additionally, integration carboxylic multiwalled carbon nanotubes into system preserves its while imparting superior conductivity. conductive exhibited great potential applications, including sensing, communication, energy harvesting. study elucidates facile for designing adhesives by ambient solvent effect, which expected offer some insights next‐generation adhesive soft materials tailored aqueous

Language: Английский

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Electrochemical and Electrical Biosensors for Wearable and Implantable Electronics Based on Conducting Polymers and Carbon-Based Materials

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(3), P. 722 - 767

Published: Dec. 29, 2023

Bioelectronic devices are designed to translate biological information into electrical signals and vice versa, thereby bridging the gap between living world electronic systems. Among different types of bioelectronics devices, wearable implantable biosensors particularly important as they offer access physiological biochemical activities tissues organs, which is significant in diagnosing researching various medical conditions. Organic conducting semiconducting materials, including polymers (CPs) graphene carbon nanotubes (CNTs), some most promising candidates for biosensors. Their unique electrical, electrochemical, mechanical properties bring new possibilities that could not be realized by utilizing metals- or silicon-based analogues. The use organic- carbon-based conductors development has emerged a rapidly growing research field, with remarkable progress being made recent years. such materials addresses issue mismatched well improvement accuracy fidelity transferred information. In this review, we highlight advances field provide insights organic (semi)conducting materials' relate these their applications wearable/implantable We also perspective on potential exciting future developments

Language: Английский

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