A biphasic drug-releasing microneedle with ROS scavenging and angiogenesis for the treatment of diabetic ulcers DOI
Xinyue He,

Lianghong Peng,

Liming Zhou

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

An ATP-activated spatiotemporally controlled hydrogel prodrug system for treating multidrug-resistant bacteria-infected pressure ulcers DOI
Xiaoliang Qi,

Yajing Xiang,

Ying Li

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 301 - 321

Published: Nov. 27, 2024

Language: Английский

Citations

24
Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy DOI
Jiajun Chen, Qi Zhou, Wenwu Cao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

Citations

16
Enhancing the performance of injectable self-activating PVA-alginate hydrogel by Ag@MXene nanozyme as NIR responsive and photoenhanced antibacterial platform for wound healing DOI

Zepeng Liang,

Zelin Sang,

Yumei Li

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123434 - 123434

Published: Feb. 27, 2025

Language: Английский

Citations

3
Hydrogen bonding-mediated phase-transition gelatin-based bioadhesives to regulate immune microenvironment for diabetic wound healing DOI

Zhuoling Tian,

Ruoheng Gu,

Wenyue Xie

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 434 - 447

Published: Jan. 5, 2025

Language: Английский

Citations

2
Development of an innovative cylindrical carbon nanofiber/gelatin-polycaprolactone hydrogel scaffold for enhanced bone regeneration DOI
Eman Serag, Ahmed Maher Eltawila,

Emad A. Salem

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141250 - 141250

Published: Feb. 1, 2025

Language: Английский

Citations

2
Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy DOI
Shuo Zhang, Xinyu Zhao, Wei Zhang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 63 - 84

Published: March 6, 2025

Language: Английский

Citations

2
Hyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers DOI
Xiaoliang Qi, Ying Li,

Yajing Xiang

et al.

Published: March 1, 2025

Language: Английский

Citations

2
Cerium dioxide nanozyme doped hybrid hydrogel with antioxidant and antibacterial abilities for promoting diabetic wound healing DOI

Shuhan Zhao,

Junhong Ling, Nan Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154517 - 154517

Published: Aug. 3, 2024

Language: Английский

Citations

15
Ferric Iron/Shikonin Nanoparticle‐Embedded Hydrogels with Robust Adhesion and Healing Functions for Treating Oral Ulcers in Diabetes DOI Creative Commons
Xiaojing Chen, Zhangping Li,

XinXin Ge

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(45)

Published: Oct. 11, 2024

Abstract Oral ulcers can be addressed using various biomaterials designed to deliver medications or cytokines. Nevertheless, the effectiveness of these substances is frequently limited in many patients due poor adherence, short retention time mouth, and less‐than‐optimal drug efficacy. In this study, a new hydrogel patch (FSH3) made silk fibroin/hyaluronic acid matrix with light‐sensitive adhesive qualities infused ferric iron/shikonin nanoparticles enhance healing effects presented. Initially, forms an barrier over mucosal lesions through straightforward local injection, solidifying when exposed UV light. Subsequently, FSH3 demonstrates superior reactive oxygen species elimination near‐infrared photothermal bactericidal activity. These characteristics support bacterial regulate oxidative levels, promoting wound's progression from inflammation tissue regeneration. diabetic rat model mimicking oral ulcers, significantly speeds up by adjusting inflammatory environment injured tissue, maintaining balance microbiota, faster re‐epithelialization. Overall, shows potential for rapid wound recovery may transform therapeutic methods managing diabetes.

Language: Английский

Citations

12
Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers DOI
Qiang Li,

Longhui Chen,

Shasha Yang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

11