Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 17, 2024
The
innate
immune
response
is
the
body's
first
line
of
defense
against
external
pathogens
and
endogenous
damage
signals.
cGAS-STING
pathway
a
crucial
component
response,
playing
key
role
in
initiating
antiviral
anti-infective
responses
by
recognizing
cytosolic
DNA.
Acute
cerebral
infarction
one
leading
causes
death
disability
worldwide,
with
primary
treatment
approach
being
restoration
blood
flow
to
ischemic
brain
tissue.
However,
reperfusion
injury
remains
significant
challenge
during
treatment.
overactivation
its
association
ischemia-reperfusion
have
been
confirmed
numerous
studies.
This
article
will
systematically
elucidate
mechanisms
pathway,
acute
infarction,
current
research
status
inhibitors,
application
nanomaterials
this
context,
evaluating
therapeutic
potential
pathway.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 18, 2024
Abstract
Acute
lung
injury
(
ALI
)
is
a
common
complication
in
patients
with
severe
burns
and
has
complex
pathogenesis
high
morbidity
mortality
rates.
A
variety
of
drugs
have
been
identified
the
clinic
for
treatment
ALI,
but
they
toxic
side
effects
caused
by
easy
degradation
body
distribution
throughout
body.
In
recent
years,
as
understanding
mechanism
underlying
improved,
scholars
developed
new
nanomaterials
that
can
be
safely
effectively
targeted
ALI.
Most
these
methods
involve
such
lipids,
organic
polymers,
peptides,
extracellular
vesicles
or
cell
membranes,
inorganic
nanoparticles
other
nanomaterials,
which
are
to
reach
tissues
perform
their
functions
through
active
targeting
passive
targeting,
process
involves
cells
organelles.
this
review,
first,
mechanisms
pathophysiological
features
occurrence
after
burn
reviewed,
potential
therapeutic
targets
summarized,
existing
classified,
possible
problems
challenges
discussed
provide
reference
development
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(2), P. 164 - 164
Published: Feb. 12, 2024
COVID-19
is
a
global
health
threat
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
and
associated
with
significant
increase
in
morbidity
mortality.
The
present
review
discusses
nuclear
factor-kappa
B
(NF-κB)
activation
its
potential
therapeutical
role
treating
COVID-19.
pathogenesis,
the
major
NF-κB
pathways,
involvement
of
SARS-CoV-2
have
been
detailed.
Specifically,
impact
on
managing
has
discussed.
As
central
player
immune
inflammatory
responses,
modulating
could
offer
strategic
avenue
for
infection.
Understanding
pathway’s
aid
developing
treatments
against
SARS-CoV-2.
Further
investigations
into
intricacies
are
required
to
reveal
effective
therapeutic
strategies
combating
infection
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 9, 2024
Abstract
Living
cell‐mediated
nanodelivery
system
is
considered
a
promising
candidate
for
targeted
antitumor
therapy;
however,
their
use
restricted
by
the
adverse
interactions
between
carrier
cells
and
nanocargos.
Herein,
novel
erythrocyte‐based
developed
assembling
renal‐clearable
copper
sulfide
(CuS)
nanodots
on
outer
membranes
of
erythrocytes
via
lipid
fusion
approach,
demonstrate
that
it
an
efficient
photothermal
platform
against
hepatocellular
carcinoma.
After
intravenous
injection
system,
CuS
assembled
can
be
released
from
accumulate
in
tumors
response
to
high
shear
stress
bloodstream,
show
excellent
effect
under
near
infrared
laser
irradiation.
Therefore,
erythrocyte‐mediated
holds
many
advantages
including
prolonged
blood
circulation
duration
enhanced
tumor
accumulation.
Significantly,
elimination
half‐life
74.75
±
8.77
h,
which
much
longer
than
(33.56
2.36
h).
Moreover,
other
two
kinds
well
onto
produce
hitchhiking
platforms.
Together,
findings
promote
not
only
development
systems
as
potential
platforms
treatment
but
also
further
clinical
translation
toward
personalized
healthcare.
Science Translational Medicine,
Journal Year:
2024,
Volume and Issue:
16(763)
Published: Sept. 4, 2024
With
the
revolutionary
progress
of
immune
checkpoint
inhibitors
(ICIs)
in
non–small
cell
lung
cancer,
identifying
patients
with
cancer
who
would
benefit
from
ICIs
has
become
critical
and
urgent.
Here,
we
report
protein
tyrosine
phosphatase
receptor
type
T
(PTPRT)
loss
as
a
precise
convenient
predictive
marker
independent
PD-L1
expression
for
anti–PD-1/PD-L1
axis
therapy.
Anti–PD-1/PD-L1
treatment
markedly
increased
progression-free
survival
PTPRT-deficient
tumors.
tumors
displayed
cumulative
DNA
damage,
cytosolic
release,
higher
tumor
mutation
burden.
Moreover,
residue
240
STING
was
identified
direct
substrate
PTPRT.
PTPRT
elevated
phosphorylation
at
Y240
thus
inhibited
its
proteasome-mediated
degradation.
released
more
IFN-β,
CCL5,
CXCL10
by
activation
pathway
infiltration,
especially
CD8
cells
natural
killer
cells,
ultimately
enhancing
efficacy
anti–PD-1
therapy
multiple
subcutaneous
orthotopic
mouse
models.
The
response
to
depends
on
tumor-intrinsic
pathway.
In
summary,
our
findings
reveal
mechanism
how
sensitive
highlight
biological
function
innate
immunity.
Considering
prevalence
mutations
negative
expression,
this
study
great
value
patient
stratification
clinical
decision-making.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Through
transcriptomic
analysis
of
glioblastoma
tissues
from
patients,
we
developed
a
combined
formulation
(NanoAid)
for
improving
glioma
synergistic
chemotherapy.
