International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136534 - 136534
Published: Oct. 13, 2024
Language: Английский
Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 131 - 151
Published: Oct. 15, 2024
Language: Английский
Citations
18
Research, Journal Year: 2024, Volume and Issue: 7
Published: Jan. 1, 2024
Thrombosis can cause life-threatening disorders. Unfortunately, current therapeutic methods for thrombosis using injecting thrombolytic medicines systemically resulted in unexpected bleeding complications. Moreover, the absence of practical imaging tools thrombi raised dangers undertreatment and overtreatment. This study develops a theranostic drug carrier, Pkr(IR-Ca/Pda-uPA)-cRGD, that enables real-time monitoring targeted process deep vein (DVT). which is prepared from Pickering-emulsion-like system, encapsulates both near-infrared-II (NIR-II) contrast agent (IR-1048 dye, loading capacity: 28%) urokinase plasminogen activators (uPAs, encapsulation efficiency: 89%), pioneering multiple drugs with contrasting hydrophilicity into one single-drug carrier. Upon intravenous injection, Pkr(IR-Ca/Pda-uPA)-cRGD considerably targets to selectively (targeting rate: 91%) disintegrates response acidic release IR-1048 dye uPA thrombolysis, respectively. Investigations indicate enabled visualization thrombolysis NIR-II DVT models, were eliminated (120 min after injection) without may be first convenient thrombolysis. It represents precision medicine rapid acquire instantaneous medical images make necessary adjustments diagnostic protocols during treatment.
Language: Английский
Citations
6
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 660, P. 585 - 596
Published: Jan. 18, 2024
Language: Английский
Citations
5
Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(17), P. 12087 - 12099
Published: April 22, 2024
Electron transfer during solid–liquid contact electrification has been demonstrated to produce reactive oxygen species (ROS) such as hydroxyl radicals (•OH) and superoxide anion (•O2–). Here, we show that a process also occurs in liquid–liquid electrification. By preparing perfluorocarbon nanoemulsions construct perfluorocarbon–water "liquid–liquid" interface, confirmed electrons were transferred from water ultrasonication-induced high-frequency •OH •O2–. The produced ROS could be applied ablate tumors by triggering large-scale immunogenic cell death tumor cells, promoting dendritic maturation macrophage polarization, ultimately activating T cell-mediated antitumor immune response. Importantly, the raw material for producing is water, so therapy not limited endogenous substances (O2, H2O2, etc.) microenvironment. This work provides new perspectives elucidating mechanism of generation free an excellent therapeutic modality.
Language: Английский
Citations
4
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 670, P. 297 - 310
Published: May 15, 2024
Language: Английский
Citations
4
Nanotechnology, Journal Year: 2024, Volume and Issue: 35(36), P. 365102 - 365102
Published: June 11, 2024
Abstract Synergistic cancer therapies have attracted wide attention owing to their multi-mode tumor inhibition properties. Especially, photo-responsive photoimmunotherapy demonstrates an emerging treatment paradigm that significantly improved efficiency. Herein, near-infrared-II responsive ovalbumin functionalized Gold-Genipin nanosystem (Au–G–OVA NRs) was designed for immunotherapy and deep photothermal therapy of breast cancer. A facile synthesis method employed prepare the homogeneous Au nanorods (Au with good dispersion. The nanovaccine developed further by chemical cross-linking Au–NRs, genipin ovalbumin. Au–G–OVA NRs outstanding aqueous solubility, biocompatibility against normal cells. possessed enhanced localized surface plasmon resonance (LSPR) effect, which extended NIR absorption in second window, enabling promising Moreover, coating provided complimentary red fluorescent prepared showed significant intracellular encapsulation efficient outcomes. 90% 4T1 cells were ablated (80 μ g ml −1 concentration) after 1064 nm laser irradiation. In addition, demonstrated vaccination phenomena facilitating OVA delivery, antigen uptake, maturation bone marrow dendritic cells, cytokine IFN- γ secretion immunosurveillance. aforementioned advantages permit utilization fluorescence imaging-guided photo-immunotherapy cancers, demonstrating a straightforward approach developing nanovaccines tailored precise treatment.
Language: Английский
Citations
4
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
The escalating prevalence of multidrug-resistant (MDR) bacterial infections has emerged as a critical global health crisis, undermining the efficacy conventional antibiotic therapies. This pressing challenge necessitates development innovative strategies to combat MDR pathogens. Advances in multifunctional drug delivery systems offer promising solutions reduce or eradicate bacteria. Inspired by fact that growth bacteria requires essential nutrients, core-shell porous poly(lactic-
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160621 - 160621
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4085 - 4103
Published: April 1, 2025
To overcome the limitations of traditional therapies in treating retinoblastoma, like low efficiency, systematic toxicity and poor biocompatibility. PPFG (PLGA-PFH-Fe3O4-GOx) nanoparticles were synthesized by ultrasound double emulsification method characterized dynamic laser scattering, ultraviolet spectrometry, confocal scanning microscopy (CLSM), transmission electron (TEM) (SEM). Phase transition low-intensity focused (LIFU) was observed microscope imaging. Cellular uptake compared between Y79 HUVEC cells. ROS production detected 2',7'-dichlorofluorescin diacetate (DCFH-DA). Cell apoptosis flow cytometry. In vivo therapeutic effects verified tumor volume, HE staining, TUNEL PCNA staining. The bio-safety serum biochemistry. NPs possesses good stability, biocompatibility tumor-preferred uptake, with a core-shell spherical structure an average size 255.6nm which increases to over 100μm under LIFU irradiation. utilized as stimuli, undergoes sequential reaction starting phase PFH causing release oxygen carried GOx/SPIO NPs, followed supplemented facilitating enzymatic activity glucose consumption GOx cells (tumor starvation), H2O2 produced during can further participate SPIO NPs-mediated Fenton (CDT), generating massive ROS. continuously generated together cut down nutrients effectively inhibited progression tumors, synergistically enhanced starvation promoted cell ultimately kills tumour No off-site injuries other major organs. this study, conduct LIFU-triggered combinational therapy on basis cascade among PFH, treat retinoblastoma vitro/vivo. It showed great potentials combating retinoblastoma.
Language: Английский
Citations
0
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114729 - 114729
Published: April 23, 2025
Language: Английский
Citations
0