Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 190, P. 476 - 487
Published: Oct. 12, 2024
Language: Английский
ACS Chemical Health & Safety, Journal Year: 2024, Volume and Issue: 31(2), P. 153 - 161
Published: March 13, 2024
Cancer is one of the most prevalent causes mortality worldwide. The arena cancer diagnosis and therapy has undergone a tremendous revolution since development nanotechnology. Due to their nanosize biocompatibility, nanoparticles are extensively employed for gene targeted drug delivery. Nanotechnology-based approaches have also shown promising advancements in utilization extracellular vesicles diagnosis, prognosis, therapy. Apart from this, CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-associated protein 9)-based nanotherapy therapeutic nanovaccines demonstrated encouraging results revolutionizing treatment. molecular imaging contrast agents can detect at very early stages, allowing prompt treatment better patient outcomes. Although offer multiple benefits administration, they additionally possess certain pharmacokinetic limitations, such as body clearance, restricted tissue penetration, confrontation with biological barriers, biodistribution, accumulation. However, improvements nanoparticle design intended resolve safety issues enhance effects these particles variety disease complications. While nanotechnology immense potential cancer, there still several challenges overcome, including guaranteeing nanomaterials, taking into account regulatory issues, creating scalable affordable solutions. Nevertheless, new developments current research hold promise further detection
Language: Английский
Citations
16
Current Research in Biotechnology, Journal Year: 2024, Volume and Issue: 7, P. 100205 - 100205
Published: Jan. 1, 2024
Nanozymes are a class of nanoparticles that can mimic enzyme activity and be used for various applications in modern clinical therapy. It has recently been observed nanozymes have multi-enzyme mimicking activities, highly stable, versatile easily modified. Moreover, they high catalytic efficiency, recovery rates, improved substrate specificity suitable mass production. The mechanisms mainly include catalase, peroxidase, oxidase, hydrolase superoxide dismutase-like which enable to as potential therapeutics against plethora infectious lifestyle disorders. cancer, inflammatory diseases, neurodegenerative neurological disorders, bacterial, fungal viral infections, wounds diseases associated with Reactive Oxygen Species. purpose writing this review is provide comprehensive compilation novel research work taken place the last few years regarding use We compiled kinds elaborated on their anti-tumorigenic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroprotective roles. Their modes action enzymatic targets also discussed. types synthesis summarized, along interactions nanozymes. Furthermore, strategies enhance compatibility between analyzed. Major focus laid therapeutic challenges future perspectives using therapy debated later sections.
Language: Английский
Citations
14
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 20, 2025
The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes
Language: Английский
Citations
1
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
5
Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 190, P. 476 - 487
Published: Oct. 12, 2024
Language: Английский
Citations
3