ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 6, 2024
Long
noncoding
RNA
(lncRNA)
has
been
shown
to
participate
in
adipogenic
differentiation
of
bone
marrow-derived
mesenchymal
stem
cells
(BMSCs).
In
this
study,
we
aimed
investigate
the
role
lncRNA-LOC646762
BMSCs.
Transcriptome
sequencing
revealed
a
positive
correlation
between
LOC646762
transcription
and
expression
marker
genes
differentiation.
Moreover,
overexpression
did
not
negatively
impact
cell
proliferation
Besides,
plays
crucial
differentiation,
as
evidenced
by
its
with
gene
expression.
Its
possible
interaction
proposed
target
C/EBPβ
suggests
involvement
essential
pathways
governing
adipogenesis.
Collectively,
our
study
outcomes
provide
valuable
insights
into
molecular
mechanisms
underlying
BMSCs
lay
strong
foundation
for
further
research
regenerative
medicine.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(1), P. 597 - 597
Published: Jan. 2, 2024
Hepatocellular
carcinoma
(HCC)
presents
a
significant
global
health
threat,
particularly
in
regions
endemic
to
hepatitis
B
and
C
viruses,
because
of
the
ongoing
pandemic
obesity
causing
metabolic-dysfunction-related
fatty
liver
disease
(MAFLD),
precursor
HCC.
The
molecular
intricacies
HCC,
genetic
epigenetic
alterations,
dysregulated
signaling
pathways
facilitate
personalized
treatment
strategies
based
on
profiling.
Epigenetic
regulation,
encompassing
DNA
methyltion,
histone
modifications,
noncoding
RNAs,
functions
as
critical
layer
influencing
HCC
development.
Long
RNAs
(lncRNAs)
are
spotlighted
for
their
diverse
roles
gene
regulation
potential
diagnostic
therapeutic
tools
cancer.
In
this
review,
we
explore
pivotal
role
lncRNAs
including
MAFLD
viral
hepatitis,
most
prevalent
risk
factors
hepatocarcinogenesis.
dysregulation
is
implicated
progression
by
modulating
chromatin
transcription,
sponging
miRNAs,
structural
functions.
studies
contribute
deeper
comprehension
pathogenesis
offer
promising
routes
precision
medicine,
highlighting
utility
early
biomarkers,
prognostic
indicators,
targets.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 27, 2024
Abstract
The
development
of
drug
resistance
remains
a
major
challenge
in
cancer
treatment.
Ferroptosis,
unique
type
regulated
cell
death,
plays
pivotal
role
inhibiting
tumour
growth,
presenting
new
opportunities
treating
chemotherapeutic
resistance.
Accumulating
studies
indicate
that
epigenetic
modifications
by
non-coding
RNAs
(ncRNA)
can
determine
vulnerability
to
ferroptosis.
In
this
review,
we
first
summarize
the
growth/development.
Then,
core
molecular
mechanisms
ferroptosis,
its
upstream
regulation,
and
downstream
effects
on
Finally,
review
recent
advances
understanding
how
ncRNAs
regulate
ferroptosis
from
such
modulate
This
aims
enhance
general
ncRNA-mediated
regulatory
which
highlighting
ncRNA-ferroptosis
axis
as
key
druggable
target
overcoming
International Journal of Biological Sciences,
Journal Year:
2024,
Volume and Issue:
20(9), P. 3621 - 3637
Published: Jan. 1, 2024
Ferroptosis,
an
emerging
type
of
programmed
cell
death,
is
initiated
by
iron-dependent
and
excessive
ROS-mediated
lipid
peroxidation,
which
eventually
leads
to
plasma
membrane
rupture
death.
Many
canonical
signalling
pathways
biological
processes
are
involved
in
ferroptosis.
Furthermore,
cancer
cells
more
susceptible
ferroptosis
due
the
high
load
ROS
unique
metabolic
characteristics,
including
iron
requirements.
Recent
investigations
have
revealed
that
plays
a
crucial
role
progression
tumours,
especially
HCC.
Specifically,
induction
can
not
only
inhibit
growth
hepatoma
cells,
thereby
reversing
tumorigenesis,
but
also
improves
efficacy
immunotherapy
enhances
antitumour
immune
response.
Therefore,
triggering
has
become
new
therapeutic
strategy
for
therapy.
In
this
review,
we
summarize
characteristics
based
on
its
underlying
mechanism
HCC
provide
possible
applications.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 23, 2024
Hepatocellular
carcinoma
is
the
most
common
form
of
primary
liver
cancer
and
poses
a
significant
challenge
to
medical
community
because
its
high
mortality
rate.
In
recent
years,
ferroptosis,
unique
cell
death,
has
garnered
widespread
attention.
Ferroptosis,
which
characterized
by
iron-dependent
lipid
peroxidation
mitochondrial
alterations,
closely
associated
with
pathological
processes
various
diseases,
including
hepatocellular
carcinoma.
Long
non-coding
RNAs
(lncRNAs),
are
type
functional
RNA,
play
crucial
regulatory
roles
in
variety
biological
processes.
this
manuscript,
we
review
lncRNAs
key
aspects
summarize
research
progress
on
ferroptosis-related
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 3, 2025
CDK4/6i,
the
first-line
drug
for
treating
ERα-positive
breast
cancer,
significantly
improves
clinical
outcomes.
However,
CDK4/6i
resistance
often
develops
and
remains
a
major
hurdle,
underlying
mechanisms
remain
challenging
to
fully
investigate.
Here,
we
used
Genome-wide
CRISPR/Cas9
library
screening
combined
with
single-cell
sequencing
screen
molecules
mediating
identified
METTL14
as
determinant
of
sensitivity.
Clinical
samples
datasets
were
analyzed
in
vitro
vivo
experiments
performed
confirm
critical
function
resistance.
Mechanistically,
can
induce
an
increase
E2F1
expression
cancer
cells
via
m6A
IGF2BP2-dependent
mechanism
thus
promote
Furthermore,
through
small
molecule
screen,
novel
inhibitor
named
WKYMVM,
which
restore
sensitivity
CDK4/6i-resistant
cells,
was
identified.
Treatment
folate-conjugated
liposomes
targeting
that
contained
both
WKYMVM
revealed
synergistic
effect
inhibition
therapy
PDX
model.
Together,
our
findings
reveal
provide
strategy
overcoming
inhibition.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 27, 2025
The
high
mortality
rate
from
hepatocellular
carcinoma
(HCC)
is
due
primarily
to
challenges
in
early
diagnosis
and
the
development
of
drug
resistance
advanced
stages.
Many
first-line
chemotherapeutic
drugs
induce
ferroptosis,
a
form
programmed
cell
death
dependent
on
ferrous
iron-mediated
oxidative
stress,
suggesting
that
ensuing
tumor
progression
may
part
stem
reduced
ferroptosis.
Since
circular
RNAs
(circRNAs)
have
been
shown
influence
development,
we
examined
whether
specific
circRNAs
regulate
drug-induced
ferroptosis
HCC.
Through
circRNA
sequencing,
identified
novel
hsa_circ_0000195
(circTTC13)
overexpressed
HCC
tissues.
This
overexpression
linked
higher
grade,
more
stage,
decreased
poorer
overall
survival.
Overexpression
CircTTC13
lines
explant
tumors
was
associated
with
increased
proliferation
rates,
enhanced
metastatic
capacity,
sorafenib,
while
also
inhibiting
Conversely,
circTTC13
silencing
malignant
characteristics
promoted
In
silico
analysis,
luciferase
assays,
fluorescence
situ
hybridization
collectively
demonstrated
directly
targets
reduces
miR-513a-5p
expression,
which
turn
leads
upregulation
negative
regulator
SLC7A11.
Moreover,
inhibition
SLC7A11
mirrored
effect
knockdown,
whereas
mimicked
overexpression.
Both
were
highly
expressed
drug-resistant
cells,
induced
reversed
sorafenib
tumors.
These
findings
identify
as
critical
driver
via
cicTTC13/miR-513a-5p/SLC7A11
axis
represents
potential
therapeutic
target
for
Cells,
Journal Year:
2025,
Volume and Issue:
14(3), P. 227 - 227
Published: Feb. 5, 2025
Long
non-coding
RNAs
(lncRNAs)
are
a
class
of
RNA
molecules
with
transcripts
longer
than
200
bp,
which
were
initially
thought
to
be
noise
from
genomic
transcription
without
biological
function.
However,
since
the
discovery
H19
in
1980
and
Xist
1990,
increasing
evidence
has
shown
that
lncRNAs
regulate
gene
expression
at
epigenetic,
transcriptional,
post-transcriptional
levels
through
specific
regulatory
actions
involved
development
cancer
other
diseases.
Despite
many
being
expressed
lower
those
protein-coding
genes
less
sequence
conservation
across
species,
have
become
an
intense
area
research.
They
exert
diverse
functions
such
as
inducing
chromatin
remodeling,
recruiting
transcriptional
machinery,
acting
competitive
endogenous
for
microRNAs,
modulating
protein–protein
interactions.
Epithelial–mesenchymal
transition
(EMT)
is
developmental
process,
associated
embryonic
development,
wound
healing,
progression.
In
context
oncogenesis,
EMT
program
transiently
activated
confers
migratory/invasive
stem
cell
(CSC)
properties
tumor
cells,
crucial
malignant
progression,
metastasis,
therapeutic
resistance.
Accumulating
revealed
play
roles
regulation
epithelial/mesenchymal
plasticity
(EMP)
stemness.
Here,
we
summarize
emerging
molecular
mechanisms
regulating
EMP
their
effects
on
initiation
progression
CSCs.
We
also
discuss
potential
diagnostic
prognostic
biomarkers
targets.
