Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 54 - 80
Published: Nov. 17, 2024
Language: Английский
Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)
Published: May 13, 2024
Abstract Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), and traumatic brain injury (TBI) exemplify complexities diversities complicate their early detection development effective treatments. Amid these challenges, emergence nanotechnology extracellular vesicles (EVs) signals new dawn for treating diagnosing CNS ailments. EVs are cellularly derived lipid bilayer nanosized particles pivotal in intercellular communication within have potential to revolutionize targeted therapeutic delivery identification novel biomarkers. Integrating with amplifies diagnostic capabilities, opening avenues managing diseases. This review focuses on examining fascinating interplay between theranostics. Through highlighting remarkable advancements unique methodologies, we aim offer valuable perspectives how approaches can bring about revolutionary change management. The objective is harness distinctive attributes forge personalized, efficient interventions disorders, thereby providing beacon hope affected individuals. In short, confluence heralds promising frontier impactful treatments against diseases, which continue pose significant challenges. By focusing personalized powerful methods, might improve quality patients.
Language: Английский
Citations
6
Small, Journal Year: 2023, Volume and Issue: 19(47)
Published: July 25, 2023
Mesenchymal stem cell (MSC)-based therapies are increasingly recognized as promising cellular therapeutics and show the ability to treat various diseases. However, underlying mechanism is not fully elucidated. Some recent studies have shown an unexpected result whereby MSCs undergo rapid apoptosis following administration but still exert therapeutic effects in some disease treatments. Such a believed associate with released apoptotic vesicles from (MSC-ApoVs). This finding inspires novel strategy for using MSC-ApoVs treatment. The present review aims summarize biogenesis, physiological functions, potentials, related mechanisms of MSC-based therapy. In addition, potential applications natural agents drug delivery vehicles proposed highlighted. hoped provide general understanding treatment inspire targeted delivery.
Language: Английский
Citations
16
Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)
Published: Nov. 21, 2024
Abstract Extracellular vesicles (EVs) are cell-derived with a phospholipid bilayer measuring 50–150 nm in diameter demonstrated therapeutic potentials. Limitations such as the natural biodistribution (mainly concentrated liver and spleen) short plasma half-life of EVs present significant challenges to their clinical translation. In recent years, growing research indicated that engineered enhanced targeting lesion sites have markedly promoted efficacy. However, there is dearth systematic knowledge on advances engineering for targeted delivery. Herein, we provide an overview mechanisms, techniques, translations applications. Enrichment at may be achieved through recognition tissue markers, pathological changes, circumvention mononuclear phagocyte system (MPS). Alternatively, external stimuli, including magnetic fields ultrasound, also employed. EV techniques fulfill functions includes genetic engineering, membrane fusion, chemical modification physical modification. A comparative statistical analysis was conducted elucidate discrepancies between diverse size, morphology, stability, efficacy vitro vivo. Additionally, summary registered trials utilizing from 2010 2023 has been provided, full discussion perspectives. This review provides comprehensive mechanisms associated delivery applications advocate further explorations accelerate
Language: Английский
Citations
5
International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)
Published: April 16, 2024
Abstract Accumulating evidence has demonstrated that apoptotic vesicles (apoVs) derived from mesenchymal stem cells (MSCs; MSC-apoVs) are vital for bone regeneration, and possess superior capabilities compared to MSCs other extracellular (such as exosomes). The osteoinductive effect of MSC-apoVs is attributed their diverse contents, especially enriched proteins or microRNAs (miRNAs). To optimize osteoinduction activity, it necessary determine the unique cargo profiles MSC-apoVs. We previously established protein landscape identified specific However, features functions miRNAs in unclear. In this study, we MSCs, MSC-apoVs, MSC-exosomes two types MSC. generated a map seven specifically MSC-exosomes, which classified apoV-specific miRNAs. Among these miRNAs, hsa-miR-4485-3p was most abundant stable. Next, explored its function apoV-mediated osteoinduction. Unexpectedly, inhibited osteogenesis promoted adipogenesis by targeting AKT pathway. Tailored apoVs with downregulated exhibited greater on regeneration than control apoVs. Like releasing brake, acquired more powerful summary, miRNA cargos, including tailored high promising apoV-based therapies regeneration.
Language: Английский
Citations
4
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2239 - 2258
Published: May 9, 2024
There has been a significant increase in the prevalence of central nervous system (CNS) disorders, resulting considerable decrease overall well-being for affected individuals. Moreover, therapeutic effectiveness CNS diseases is greatly impeded by inability majority small molecule drugs and almost all large to penetrate brain barrier. Therefore, it crucial develop an efficient drug delivery effectively treat disorders transporting agents CNS. Cell-penetrating peptides (CPPs), which are well-known their membrane penetration capabilities ability facilitate rapid passage across barrier, offer potential strategy transportation macromolecules This study provided comprehensive overview utilization CPP-mediated management summarized recent advancements clinic, aiming establish scientific foundation application CPPs treatment diseases.
Language: Английский
Citations
4
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 1, 2025
Extracellular particles (EPs), including extracellular vesicles (EVs) and non-vesicular (NVEPs), are multimolecular biomaterials released by cells that play a crucial role in intercellular communication. Recently, new subtypes of EPs associated with central nervous system (CNS), such as exophers supermeres have been identified. These provide perspectives for understanding the pathological progression CNS disorders confer potential diagnostic value liquid biopsies neurodegenerative diseases (NDs). Moreover, emerged promising drug delivery vehicles targeted platforms CNS-specific therapies. In this review, we delineate landscape EP their roles pathophysiology diseases. We also review recent advances EP-based diagnosis NDs highlight importance analytical single-particle resolution exploitation biomarkers. Furthermore, summarize application engineered EVs treatment outline underexplored NVEPs novel therapeutic agents.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 15, 2025
Abstract There is a desperate need for precise nanomedications to treat ischemic cerebral injury. Yet, the drawbacks of poor delivery efficiency and off‐target toxicity in pathologic parenchyma traditional antioxidants against stroke result inadequate brain accumulation. M13 bacteriophages are highly phagocytosed by M1‐polarized microglia can be carried toward neuroinflammatory sites. Here, bio‐active, inhalable, Ce 0.9 Zr 0.1 O 2 ‐backpacked‐M13 phage (abbreviated as CZM) developed demonstrates how taken up different phenotypes’ microglia. With M1 microglia's proliferating migrating, CZM extensively specifically delivered site core penumbra, where surviving nerve cells shielded from secondary oxidative stress inflammatory cascade initiated reactive oxygen species (ROS). non‐invasive administration, effectively alleviates damage apoptosis neurons eliminating ROS generated hyperactive secure effective strategy targeted therapy maladies offered this research.
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 21, 2025
Mesenchymal stem cells (MSCs), an accessible and less ethically controversial class of adult cells, have demonstrated significant efficacy in treating a wide range diseases both the preclinical clinical phases. However, we do not yet clear understanding mechanisms by which MSCs exert their therapeutic effects vivo. We found that transplanted go apoptotic fate within 24 h vivo irrespective route administration. Still, short-term survival affect long-term efficacy. An increasing number studies transplantation (ApoMSCs) show similar or even better than viable MSCs, including variety disease models such as inflammatory diseases, skin damage, bone organ etc. Although exact mechanism has to be explored, recent shown undergo apoptosis are phagocytosed phagocytes, thereby exerting immunomodulatory effects. The extracellular vesicles secreted ApoMSCs (MSC-ApoEVs) play role promoting immunomodulation, endogenous cell regeneration, angiogenesis due properties inheritance molecular characteristics from parental MSCs. On this basis, review aims deeply explore applications secretion MSC-ApoEVs, well challenges they face.
Language: Английский
Citations
0
Precision medicine and engineering., Journal Year: 2025, Volume and Issue: unknown, P. 100022 - 100022
Published: Feb. 1, 2025
Language: Английский
Citations
0
Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(5)
Published: May 1, 2025
ABSTRACT Objective We seek to investigate the efficacy of safflower yellow pigment in mitigating cerebral ischemia‐reperfusion injury by examining its effects on protein nitration and oxidative modification. Methods A total 160 patients with acute ischemic stroke admitted department neurology Xingtai people's hospital were included this study. This study was a retrospective Patients divided into control group ( n = 80) observation according whether used. The received conventional treatment, pigment. Results Baseline characteristics did not significantly differ between two groups p > 0.05). Serum nitrosine levels lower compared after 24 h one week treatment < Similarly, serum carbonylated exhibited NIHSS modified rankin scale (mRS) scores, reduced area. Furthermore, malondialdehyde (MDA), C‐reactive (CRP), tumor necrosis factor‐alpha (TNF‐α) lower, while superoxide dismutase (SOD) activity higher Conclusion Safflower demonstrates significant neuroprotective reducing oxidation nitration, improving neurological function, area, attenuating stress inflammation.
Language: Английский
Citations
0