Firing up “cold” tumors: Ferroptosis causes immune activation by improving T cell infiltration

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117298 - 117298

Published: Aug. 15, 2024

Immune checkpoint blocking (ICB), a tumor treatment based on the mechanism of T-cell activation, has shown high efficacy in clinical trials, but not all patients benefit from it. inhibitors (ICIs) do respond to cold tumors that lack effective infiltration well hot with sufficient infiltration. How convert an unresponsive into responsive is important topic cancer immunotherapy. Ferroptosis, newly discovered immunogenic cell death (ICD) form, great potential therapy. In process deeply understanding formation, it was found ferroptosis showed powerful immune-activating effect by improving infiltration, and combination ICB therapy significantly enhanced anti-tumor efficacy. This paper reviews complex relationship between T cells ferroptosis, as summarizes various mechanisms which enhances infiltration: reactivation reversal immunosuppressive microenvironment (TME), recent advances ICI targeted therapies, provides guidance for better tumors.

Language: Английский

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Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The designability and high reactivity of nanotechnology provide strategies for antitumor therapy by regulating the redox state in tumor cells. Here, we synthesize a kind vanadium dioxide nanoparticle encapsulated bovine serum albumin containing disulfide bonds (VSB NPs) photothermal-enhanced ferroptosis pyroptosis effects. Mechanism studies show that can effectively consume overexpressed glutathione (GSH) microenvironment, leading to decrease peroxidase 4 (GPX4) activity. Simultaneously, tetravalent induce catalytic reaction H2O2, producing plenty toxic hydroxyl radicals (·OH) singlet oxygen (1O2), cell ferroptosis. In addition, consumption also lead degradation nanoparticles into high-valent vanadates, activating thermal protein domain-associated 3 (NLRP3) inflammasomes causing pyroptosis. It is worth mentioning VSB NPs not only ablate cells under near-infrared light irradiation but further disrupt homeostasis thereby enhancing induced biodegradable vanadium-based nanomaterials. This strategy, based on biological effects regulate cells, provides possibilities cancer treatment.

Language: Английский

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GSH-responsive degradable nanodrug for glucose metabolism intervention and induction of ferroptosis to enhance magnetothermal anti-tumor therapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 3, 2024

The challenges associated with activating ferroptosis for cancer therapy primarily arise from obstacles related to redox and iron homeostasis, which hinder the susceptibility of tumor cells ferroptosis. However, specific mechanisms resistance, especially those intertwined abnormal metabolic processes within cells, have been consistently underestimated. In response, we present an innovative glutathione-responsive magnetocaloric nanodrug termed LFMP. LFMP consists lonidamine (LND) loaded into PEG-modified magnetic nanoparticles a Fe

Language: Английский

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Transition Metal Oxide Nanomaterials: New Weapons to Boost Anti-Tumor Immunity Cycle

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(13), P. 1064 - 1064

Published: June 21, 2024

Semiconductor nanomaterials have emerged as a significant factor in the advancement of tumor immunotherapy. This review discusses potential transition metal oxide (TMO) realm anti-tumor immune modulation. These binary inorganic semiconductor compounds possess high electron mobility, extended ductility, and strong stability. Apart from being primary thermistor materials, they also serve potent agents enhancing immunity cycle. The diverse oxidation states TMOs result range electronic properties, metallicity to wide-bandgap insulating behavior. Notably, titanium oxide, manganese iron zinc copper garnered interest due their presence tissues therapeutic implications. nanoparticles (NPs) kickstart cycle by inducing immunogenic cell death (ICD), prompting release ICD tumor-associated antigens (TAAs) working conjunction with various therapies trigger dendritic (DC) maturation, T response, infiltration. Furthermore, can alter microenvironment (TME) reprogramming immunosuppressive macrophages into an inflammatory state, thereby impeding growth. aims bring attention research community regarding diversity significance cycle, while underscoring challenges associated using

Language: Английский

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β-elemene, a sesquiterpene constituent from Curcuma phaeocaulis inhibits the development of endometriosis by inducing ferroptosis via the MAPK and STAT3 signaling pathways

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119344 - 119344

Published: Jan. 1, 2025

Language: Английский

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Nanotherapies Based on ROS Regulation in Oral Diseases

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated a pivotal player modulating these intricate pathological processes, exerting significant roles restoring oral functionality maintaining tissue structural integrity. Due to enzyme‐like catalytic properties, unique composition, intelligent design, ROS‐based nanomaterials have garnered considerable attention nanomedicine. Such capacity influence spatiotemporal dynamics ROS biological systems, guiding evolution intra‐ROS facilitate therapeutic interventions. This paper reviews latest advancements functional customization, medical applications nanomaterials. Through analysis components designs various novel nanozymes nanoplatforms responsive different stimuli dimensions, it elaborates on impacts dynamic behavior potential regulatory mechanisms body. Furthermore, discusses prospects strategies nanotherapies based scavenging generation diseases, offering alternative insights for design development treating ROS‐related conditions.

Language: Английский

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Lactoferrin Nanoparticle-Vanadium Complex: A Promising High-Efficiency Agent against Glioblastoma by Triggering Autophagy and Ferroptosis

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Glioblastoma represents the most aggressive type of brain cancer with minimal clinical advancements in recent decades attributed to absence efficient drug delivery strategies. In this study, we synthesized a series vanadium complexes (V1-V4) and then constructed lactoferrin (LF)-V4 nanoparticle (NP) system. The nanoplatform crossed blood-brain barrier by binding low-density lipoprotein receptor-associated protein-1 selectively targeted glioblastoma, ultimately inhibiting growth situ glioblastoma tumors. LF-V4 NPs induced autophagic cell death U87-MG cells generating reactive oxygen species (ROS) that damaged mitochondria. Further studies revealed triggered lipid peroxidation through accumulation ROS, depletion GSH, downregulation GPX4 SLC7A11, leading ferroptosis cells.

Language: Английский

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Arsenene-Vanadene Nanodots Co-Activate Apoptosis/Ferroptosis for Enhanced Chemo-Immunotherapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Advances in Sonodynamic Therapy: Focus on Ferroptosis

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Ferroptosis is a nonapoptotic form of cell death discovered in 2012. Noninvasive treatments regulating ferroptosis are important for wide range diseases. Among the noninvasive treatments, sonodynamic therapy (SDT) has become promising due to its strong tissue penetration and few side effects. In recent years, targeted drug delivery platforms constructed on basis SDT have provided an efficient mode regulation ferroptosis. Based latest research reports, this Perspective introduces basic mechanism influencing factors therapeutic effects, elucidates significance ferroptosis-targeted SDT, summarizes studies through different pathways. We also present innovative composite ultrasound-responsive platforms. Finally, brief summary outlook based current presented.

Language: Английский

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Self‐Adaptive Dynamic Hydrogel Disrupts Ironclad Defense to Augment Photothermal‐Catalytic Therapy Against Melanoma Recurrence and Promote Post‐Surgical Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Post‐surgical photothermal therapy for melanoma faces significant challenges including resistance, tumor recurrence, and wound healing. In response, a self‐adaptive hydrogel (VPHCh) is designed, synthesized from carboxymethyl chitosan, integrated with vanadium‐polydopamine (V‐PDA) nanoplatform, which significantly enhances both catalytic properties. The advanced effectively inhibits recurrence facilitates healing through the precise modulation of V‐PDA release dynamics. infection microenvironment, rapidly released, delivering outstanding effects. Furthermore, synergistic actions reactions, induces endoplasmic reticulum stress, disrupting Wnt/β‐catenin signaling pathway enhancing V 5+ ‐mediated glutathione depletion, thereby increasing cell sensitivity to ferroptosis. Importantly, lipid peroxidation during ferroptosis further degradation heat shock protein 90, markedly augmenting effects therapies. Additionally, within VPHCh enables controlled sustained V‐PDA, promoting proliferation, angiogenesis, M2 macrophage polarization, accelerating also exhibits remarkable antibacterial properties, inhibiting bacterial facilitating Consequently, this dynamically adaptive represents promising adjuvant in post‐surgical treatment, offering substantial potential inhibit accelerate

Language: Английский

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