Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: May 17, 2025
Language: Английский
ACS Nano, Journal Year: 2024, Volume and Issue: 18(46), P. 31713 - 31736
Published: Nov. 7, 2024
Sensitive and quantitative detection of chemical biological molecules for screening, diagnosis monitoring diseases is essential to treatment planning response monitoring. Electrochemical biosensors are fast, sensitive, easy miniaturize, which has led rapid development in clinical diagnosis. Benefiting from their excellent molecular recognition ability high programmability, DNA nanomaterials could overcome the Debye length electrochemical by simple design well suited as elements biosensors. Therefore, enhance sensitivity specificity biosensors, significant progress been made recent years optimizing design. Here, establishment sensing strategies based on reviewed detail. First, structural nanomaterial examined improving overcoming length. In addition, electrical signal transduction amplification reviewed, applications nanomaterial-based integrated devices further summarized. Finally, main opportunities challenges detecting disease biomarkers presented an aim guide with specificity.
Language: Английский
Citations
10
Science Advances, Journal Year: 2025, Volume and Issue: 11(3)
Published: Jan. 15, 2025
Precise and rapid disease detection is critical for controlling infectious diseases like COVID-19. Current technologies struggle to simultaneously identify viral RNAs host immune antibodies due limited integration of sample preparation detection. Here, we present acoustofluidic integrated molecular diagnostics (AIMDx) on a chip, platform enabling high-speed, sensitive immunoglobulins [immunoglobulin A (IgA), IgG, IgM] nucleic acids. AIMDx uses acoustic vortexes Gor’kov potential wells at 1/10,000 subwavelength scale concurrent isolation viruses while excluding cells, bacteria, large (>200 nanometers) vesicles from saliva samples. The chip facilitates on-chip RNA enrichment, lysis in 2 minutes, via transcription loop–mediated isothermal amplification, alongside electrochemical sensing antibodies, including mucin-masked IgA. achieved nearly 100% recovery 32-fold improvement, an immunity marker sensitivity 15.6 picograms per milliliter. This breakthrough provides transformative tool multiplex diagnostics, enhancing early
Language: Английский
Citations
1
Biomedical Microdevices, Journal Year: 2025, Volume and Issue: 27(1)
Published: Feb. 26, 2025
Language: Английский
Citations
1
ACS Sensors, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Recently, flexible electronics have significantly transformed information and communications technology (ICT). In particular, wearable devices, via integration with attachable biosensors, driven the development of new types biosensors diagnostic devices for point-of-care testing (POCT). Moreover, electrochemical can be applied to diagnose diseases in real time based on synergistic effect generated from incorporation technique. Besides, improve sensitivity while retaining their wearability, novel nanomaterials nanotechnologies been introduced. this review, recent studies nanotechnology-based accurate disease diagnosis are discussed. First, widely used techniques developing electrodes, including nanolithography- nano/microneedle-based patches, presented. Next, latest such as diabetes dermatitis discussed by categorizing into categories. Finally, review explores research trends application nanotechnology-enabled nanopatterning nano/microneedle technologies biosensors. This suggests approaches methods real-time under POCT applications.
Language: Английский
Citations
1
Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(6)
Published: May 10, 2024
Abstract The COVID-19 pandemic underlines the need for effective strategies controlling virus spread and ensuring sensitive detection of SARS-CoV-2. This review presents potential nanomaterial-enabled optical biosensors rapid low-cost SARS-CoV-2 biomarkers, demonstrating a comprehensive analysis including colorimetric, fluorescence, surface-enhanced Raman scattering, surface plasmon resonance methods. Nanomaterials metal-based nanomaterials, metal–organic frame–based nanoparticles, nanorods, nanoporous materials, nanoshell magnetic nanoparticles employed in production are presented detail. also discusses principles, fabrication methods, nanomaterial synthesis, their applications four categories: antibody-based, antigen-based, nucleic acid–based, aptamer-based biosensors. critical includes reports published literature between years 2021 2024. In addition, offers insights into nanobiosensors diagnosis COVID-19. integration artificial intelligence machine learning technologies with is proposed to improve efficiency diagnostic systems future scenarios. Graphical
Language: Английский
Citations
7
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 939, P. 173333 - 173333
Published: May 17, 2024
Language: Английский
Citations
6
Results in Engineering, Journal Year: 2024, Volume and Issue: unknown, P. 103428 - 103428
Published: Nov. 1, 2024
Language: Английский
Citations
6
Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111938 - 111938
Published: Oct. 1, 2024
Language: Английский
Citations
6
Frontiers in Lab on a Chip Technologies, Journal Year: 2024, Volume and Issue: 3
Published: Dec. 20, 2024
Microfluidic paper-based analytical devices (µPADs) have gained significant attention in science and technology due to their numerous advantages over traditional techniques, including cost-effectiveness, miniaturization, sustainability. µPADs are widely used point-of-care diagnostics, health monitoring, environmental detection, food safety, forensics, security. Since the first report 2007, there been substantial advancements fabrication detection methods, applications. Over years, efforts made improve manufacturing scalability, user-friendliness, sustainability of µPADs. In this review, we explore general trends fabrication, sensing applications µPADs, highlighting key improvements innovations. We also examine eco-friendliness present real-world success stories from field studies citizen initiatives. Additionally, address challenges associated with transitioning lab field. Finally, outlook for propose strategies usefulness various fields.
Language: Английский
Citations
5
Biosensors, Journal Year: 2024, Volume and Issue: 14(4), P. 165 - 165
Published: March 29, 2024
The screen-printed carbon electrode (SPCE) is a useful technology that has been widely used in the practical application of biosensors oriented to point-of-care testing (POCT) due its characteristics cost-effectiveness, disposability, miniaturization, wide potential window, and simple design. Compared with gold or platinum electrodes, surface modification difficult because chemically physically stable. Oxygen plasma (O2) can easily produce carboxyl groups on surface, which act as scaffolds for covalent bonds. However, effect O2-plasma treatment performance remains be investigated from an electrochemical perspective, sensor improved by clarifying conditions plasma-treated biosensors. In this research, we compared antibody physical adsorption, using our novel immunosensor based nanoparticles (AuNPs). Consequently, produced changed properties owing electrostatic interactions. study, following four cases SPCE modification: O2-plasma-treated electrode/covalent-bonded (a); electrode/physical adsorbed (b); bare (c); absorbed (d). limits detection (LOD) were 0.50 ng/mL (a), 9.7 (b), 0.54 (c), 1.2 slopes linear response range 0.039, 0.029, 0.014, 0.022. LOD (a) was 2.4 times higher than conventional condition (d), slope showed sensitivity other (b~d). This generated many increased number adsorption sites. summary, found modify improve amount modifications. future, could method modifying various molecular recognition elements printed electrodes.
Language: Английский
Citations
4