Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 6, 2025
Neutrophil
extracellular
traps
(NETs)
participate
in
both
host
defense
and
the
pathogenesis
of
various
diseases,
such
as
infections,
thrombosis,
tumors.
While
they
help
capture
eliminate
pathogens,
NETs'
excessive
or
dysregulated
formation
can
lead
to
tissue
damage
disease
progression.
Therapeutic
strategies
targeting
NET
modulation
have
shown
potential,
but
challenges
remain,
particularly
achieving
precise
drug
delivery
maintaining
stability.
Nanoparticle
(NP)-based
systems
offer
innovative
solutions
for
overcoming
limitations
conventional
therapies.
This
review
explores
biological
mechanisms
formation,
their
interactions
with
NPs,
therapeutic
applications
NP-based
modulating
NETs.
We
discuss
how
NPs
be
designed
either
promote
inhibit
provide
a
comprehensive
analysis
potential
treating
NET-related
diseases.
Additionally,
we
address
current
future
prospects
therapies
research,
aiming
bridge
gap
between
nanotechnology
development
novel
approaches.
Experimental & Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
56(4), P. 836 - 849
Published: April 1, 2024
Abstract
Exosomes,
which
are
nanosized
vesicles
secreted
by
cells,
attracting
increasing
interest
in
the
field
of
biomedical
research
due
to
their
unique
properties,
including
biocompatibility,
cargo
loading
capacity,
and
deep
tissue
penetration.
They
serve
as
natural
signaling
agents
intercellular
communication,
inherent
ability
carry
proteins,
lipids,
nucleic
acids
endows
them
with
remarkable
therapeutic
potential.
Thus,
exosomes
can
be
exploited
for
diverse
applications,
chemotherapy,
gene
therapy,
photothermal
therapy.
Moreover,
capacity
homotypic
targeting
self-recognition
provides
opportunities
personalized
medicine.
Despite
advantages
novel
agents,
there
several
challenges
optimizing
efficiency
structural
stability
defining
exosome
origins.
Future
should
include
development
large-scale,
quality-controllable
production
methods,
refinement
drug
strategies,
extensive
vivo
studies
clinical
trials.
unresolved
difficulties,
use
efficient,
stable,
safe
delivery
systems
is
an
interesting
area
research.
Therefore,
this
review
describes
summarizes
cutting-edge
published
high-impact
journals
that
have
introduced
or
enhanced
effects
using
a
system
past
2
years.
We
provide
informative
overview
current
state
research,
highlighting
properties
applications
exosomes.
also
emphasize
future
directions,
underscoring
importance
addressing
key
issues
field.
With
review,
we
encourage
researchers
further
develop
exosome-based
drugs
application,
such
may
among
most
promising
next-generation
therapeutics.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
In
designing
aerosolized
drugs,
the
challenge
lies
in
achieving
optimal
penetration
and
retention.
Existing
delivery
systems
prioritize
larger
particles
for
prolonged
intrapulmonary
retention,
compromising
speed.
Conversely,
smaller
nanoparticles
face
rapid
clearance
limited
RNA
sponges
featuring
multiple
microRNA
binding
sites
exhibit
promising
potential
gene
expression
regulation.
However,
complex
structure
of
frequently
utilized
cyclic
sponge
impedes
cellular
uptake,
restricting
its
application.
This
study
proposes
an
innovative
approach
using
a
compact
tetrahedral
framework
nucleic
acid
to
construct
inhalable
sponge.
Distinguished
by
simplified
structure,
this
ensures
effective
inhibition,
tissue
penetration,
residency
through
prompt
endocytosis.
Validated
acute
lung
inflammation
models,
demonstrates
swift
restoration
local
immune
homeostasis.
design
addresses
critical
need
aerosol
vehicles
that
balance
efficient
sustained
offering
solution
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(32)
Published: Sept. 25, 2023
Extracellular
vesicles
(EVs),
involved
in
essential
physiological
and
pathological
processes
of
the
organism,
have
emerged
as
powerful
tools
for
disease
treatment
owing
to
their
unique
natural
biological
characteristics
artificially
acquired
advantages.
However,
limited
targeting
ability,
insufficient
production
yield,
low
drug-loading
capability
simplex
EVs
greatly
hindered
development
clinical
translation.
Therefore,
establishment
multifunctional
hybrid
membrane
nanovesicles
(HMNVs)
with
favorable
adaptability
flexibility
has
become
key
expanding
practical
application
EVs.
This
timely
review
summarizes
current
progress
HMNVs
biomedical
applications.
Different
preparation
strategies
including
physical,
chemical,
chimera
approaches
are
first
discussed.
then
individually
describes
diverse
types
based
on
homologous
or
heterologous
cell
substances,
a
fusion
liposome,
well
bacterial
membrane.
Subsequently,
specific
emphasis
is
placed
highlight
applications
toward
various
diseases
representative
examples.
Finally,
ongoing
challenges
prospects
currently
developed
translational
briefly
presented.
will
not
only
stimulate
broad
interest
among
researchers
from
disciplines
but
also
provide
valuable
insights
promising
nanoplatforms
precision
medicine.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1509 - 1538
Published: Feb. 1, 2024
Abstract:
Lungs
experience
frequent
interactions
with
the
external
environment
and
have
an
abundant
supply
of
blood;
therefore,
they
are
susceptible
to
invasion
by
pathogenic
microorganisms
tumor
cells.
However,
limited
pharmacokinetics
conventional
drugs
in
lungs
poses
a
clinical
challenge.
The
emergence
different
nano-formulations
has
been
facilitated
advancements
nanotechnology.
Inhaled
nanomedicines
exhibit
better
targeting
prolonged
therapeutic
effects.
Although
great
potential,
still
present
several
unknown
risks.
Herein,
we
review
(1)
physiological
anatomy
their
biological
barriers,
(2)
toxicology
nanomaterial
formulations
lungs;
(3)
current
nanomaterials
that
can
be
applied
respiratory
system
related
design
strategies,
(4)
applications
inhaled
treating
disorders,
vaccine
design,
imaging
detection
based
on
characteristics
nanomaterials.
Finally,
(5)
analyze
summarize
challenges
prospects
for
disease
applications.
We
believe
nanomaterials,
particularly
nano-formulations,
excellent
application
diseases.
emphasize
simultaneous
toxic
side
effects
must
considered
during
these
emerging
medicines.
This
study
aims
offer
comprehensive
guidelines
valuable
insights
conducting
research
domain
system.
Keywords:
nanoparticles,
system,
lungs,
nanotechnology
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 18, 2024
Abstract
Acute
lung
injury
(
ALI
)
is
a
common
complication
in
patients
with
severe
burns
and
has
complex
pathogenesis
high
morbidity
mortality
rates.
A
variety
of
drugs
have
been
identified
the
clinic
for
treatment
ALI,
but
they
toxic
side
effects
caused
by
easy
degradation
body
distribution
throughout
body.
In
recent
years,
as
understanding
mechanism
underlying
improved,
scholars
developed
new
nanomaterials
that
can
be
safely
effectively
targeted
ALI.
Most
these
methods
involve
such
lipids,
organic
polymers,
peptides,
extracellular
vesicles
or
cell
membranes,
inorganic
nanoparticles
other
nanomaterials,
which
are
to
reach
tissues
perform
their
functions
through
active
targeting
passive
targeting,
process
involves
cells
organelles.
this
review,
first,
mechanisms
pathophysiological
features
occurrence
after
burn
reviewed,
potential
therapeutic
targets
summarized,
existing
classified,
possible
problems
challenges
discussed
provide
reference
development
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 2317 - 2338
Published: Feb. 1, 2025
Severe
acute
pancreatitis
associated
with
lung
injury
(SAP-ALI)
is
a
critical
condition
high
mortality
rate.
Investigating
the
pathogenesis
of
SAP-ALI
and
developing
effective
treatments
are
urgently
needed.
Chaihuang
Qingfu
Pills
(CHQF),
traditional
Chinese
medicine
modified
from
Qingyi
Decoction,
has
been
approved
for
treating
(AP).
However,
its
role
in
underlying
mechanisms
remain
unclear.
92
AP
patients
were
enrolled
to
observe
protective
effect
CHQF
on
AP-ALI.
L-arginine
was
used
establish
animal
model.
UHPLC-MS/MS
identify
components
absorbed
into
serum.
Transcriptomics
analysis,
network
pharmacology,
proteomics
approaches
explore
molecular
mechanism.
In
vivo
vitro
experiments
conducted
validate
relevant
findings.
Clinical
data
indicated
reduced
incidence
ALI
58.33%
36.36%
patients.
Animal
demonstrated
that
decreased
mortality,
attenuated
organ
damage,
inhibited
systemic
inflammation
pathological
SAP
mice.
Differential
expression
analysis
weighted
gene
co-expression
(WGCNA)
identified
146
SAP-related
differentially
expressed
genes
(DEGs)
GSE194331
dataset.
acquired
26
blood
271
therapeutic
targets.
Integrated
obtained
52
core
targets
SAP.
Proteomic
216
proteins
treatment
SAP-ALI.
Joint
found
MMP9
NLRP3
only
common
Both
confirmed
levels
pyroptosis
alveolar
macrophages
(AMs)
under
conditions.
Moreover,
inhibitor
suppressed
AMs
pyroptosis.
exerted
by
inhibiting
macrophage
through
MMP9-NLRP3
pathway,
providing
novel
strategy
