Biomimetic nanocarriers in cancer therapy: based on intercellular and cell-tumor microenvironment communication DOI Creative Commons
Mengyuan He, Aixue Li, Yongwei Gu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 6, 2024

Inspired by the concept of "natural camouflage," biomimetic drug delivery systems have emerged to address limitations traditional synthetic nanocarriers, such as poor targeting, susceptibility identification and clearance, inadequate biocompatibility, low permeability, systemic toxicity. Biomimetic nanocarriers retain proteins, nucleic acids, other components parent cells. They not only facilitate but also serve communication media inhibit tumor This paper delves into mechanisms between various cell-derived cells, microenvironment, well their applications in delivery. In addition, additional capabilities conferred on modified targeting environmental responsiveness, are outlined. Finally, we propose future development directions for hoping inspire researchers design efforts ultimately achieve clinical translation.

Language: Английский

Lymph-targeted high-density lipoprotein-mimetic nanovaccine for multi-antigenic personalized cancer immunotherapy DOI Creative Commons
Mingqi Liu, Yang Feng, Yougong Lu

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(11)

Published: March 13, 2024

Cancer vaccines show huge potential for cancer prevention and treatment. However, their efficacy remains limited due to weak immunogenicity regarding inefficient stimulation of cytotoxic T lymphocyte (CTL) responses. Inspired by the unique characteristic biological function high-density lipoprotein (HDL), we here develop an HDL-mimicking nanovaccine with commendable lymph-targeted capacity potently elicit antitumor immunity using lipid nanoparticle that is co-loaded specific cytomembrane harboring a collection tumor-associated antigens immune adjuvant. The nanoparticulate impact explored on efficiency lymphatic targeting dendritic cell uptake. optimized promotes co-delivery adjuvants lymph nodes maintains antigen presentation cells, resulting in long-term surveillance as elevated frequency CTLs within lymphoid organs tumor tissue. Immunization suppresses formation growth augments therapeutic checkpoint inhibitors notably high-stemness melanoma mouse models.

Language: Английский

Citations

33
Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics DOI Open Access
Andrés Fernández-Borbolla, Lorena García‐Hevia, Mónica L. Fanárraga

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2071 - 2071

Published: Feb. 8, 2024

Nanoencapsulation has become a recent advancement in drug delivery, enhancing stability, bioavailability, and enabling controlled, targeted substance delivery to specific cells or tissues. However, traditional nanoparticle faces challenges such as short circulation time immune recognition. To tackle these issues, cell membrane-coated nanoparticles have been suggested practical alternative. The production process involves three main stages: lysis membrane fragmentation, isolation, coating. Cell membranes are typically fragmented using hypotonic with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. Coating can be achieved extrusion, sonication, combination of both methods. Notably, this analysis reveals the absence universally applicable method for coating, stages differ significantly their procedures. This review explores current developments approaches nanoparticles, highlighting potential an effective alternative various therapeutic applications.

Language: Английский

Citations

15
Biomimetic Gold Nanorods‐Manganese Porphyrins with Surface‐Enhanced Raman Scattering Effect for Photoacoustic Imaging‐Guided Photothermal/Photodynamic Therapy DOI
Huihui Liu, Cunji Gao,

Peijing Xu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(42)

Published: June 20, 2024

Abstract Surface‐enhanced Raman scattering (SERS) imaging integrating photothermal and photodynamic therapy (PTT/PDT) is a promising approach for achieving accurate diagnosis effective treatment of cancers. However, most available reporters show multiple signals in the fingerprint region, which overlap with background from cellular biomolecules. Herein, 4T1 cell membrane‐enveloped gold nanorods‐manganese porphyrins system (GMCMs) designed successfully fabricated as biomimetic theranostic nanoplatform. Manganese are adsorbed on surface Au nanorods via terminal alkynyl group. Cell membrane encapsulation protects manganese falling off nanorods. The GMCMs confirm specific homologous targeting to cells good dispersibility, excellent photoacoustic (PA) properties, preferable 1 O 2 generation performance. exhibit distinct SERS silent region without endogenous biomolecule interference both vitro vivo. ions could not only quench fluorescence enhance effect but also deplete GSH increase yield. Both vivo studies demonstrate that effectively eradicate tumors through SERS/PA imaging‐guided PTT/PDT. This study provides feasible strategy augmenting effects group GSH‐depletion PTT/PDT efficacy.

Language: Английский

Citations

15
At the crossroad of nanotechnology and cancer cell membrane coating: Expanding horizons with engineered nanoplatforms for advanced cancer therapy harnessing homologous tumor targeting DOI
Huachun Pan, Shumin Yang, Lun Gao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215712 - 215712

Published: Feb. 15, 2024

Language: Английский

Citations

14
Heterocyclic-Modified Imidazoquinoline Derivatives: Selective TLR7 Agonist Regulates Tumor Microenvironment against Melanoma DOI
Jiaxin Ou, Lu Zheng, Yanlin Chen

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 3321 - 3338

Published: Feb. 16, 2024

Immunotherapy targeting the toll-like receptor 7 (TLR7) is a promising strategy for cancer treatment. Herein, we describe design and synthesis of series imidazoquinoline-based TLR7 agonists assess NF-κB pathway activation using HEK-Blue hTLR7 cells to identify most potent small-molecule agonist, SMU-L11 (EC50 = 0.024 ± 0.002 μM). In vitro experiments demonstrated that specifically activated TLR7, resulting in recruitment MyD88 adaptor protein MAPK signaling pathways. Moreover, was found exert immune-enhancing effects by significantly inducing secretion proinflammatory cytokines murine dendritic cells, macrophages, human peripheral blood mononuclear while promoting M1 macrophage polarization. vivo studies B16-F10 mouse tumor model showed enhanced immune cell augmented CD4+ T CD8+ T-cell proliferation, directly killing inhibiting growth.

Language: Английский

Citations

8
Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances DOI

Gaoli Niu,

Hong Wang, Yanhong Zhai

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102286 - 102286

Published: May 6, 2024

Language: Английский

Citations

7
Enzyme-responsive design combined with photodynamic therapy for cancer treatment DOI

Siying Zhi,

Meixin Huang,

Kui Cheng

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(5), P. 103965 - 103965

Published: March 27, 2024

Language: Английский

Citations

6
Engineering Bimetallic Polyphenol for Mild Photothermal Osteosarcoma Therapy and Immune Microenvironment Remodeling by Activating Pyroptosis and cGAS‐STING Pathway DOI
Kaiyuan Liu,

Pengfei Zan,

Zihua Li

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 1, 2024

Abstract The immunosuppressive tumor microenvironment (ITME) of osteosarcoma (OS) poses a significant obstacle to the efficacy existing immunotherapies. Despite attempt novel immune strategies such as checkpoint inhibitors and vaccines, their effectiveness remains suboptimal due inherent difficulty in mitigating ITME simultaneously from both system. promotion anti‐tumor immunity through induction immunogenic cell death activation cGAS‐STING pathway has emerged potential counter stimulate systemic antitumor responses. Here, bimetallic polyphenol‐based nanoplatform (Mn/Fe‐Gallate nanoparticles coated with membranes is presented, MFG@TCM) which combines mild photothermal therapy (PTT) for reversing via inducing pyroptosis OS cells activating dendritic (DCs). immunostimulatory pathways, syngeneic effect, exerted substantial positive impact on promoting secretion damage‐associated molecular patterns (DAMPs) proinflammatory cytokines, favors remodeling microenvironment. Consequently, effector T led notable response, effectively inhibiting growth primary distant tumors. This study proposes new method treating using PTT mudulation, showing promise overcoming current treatment limitations.

Language: Английский

Citations

6
Engineered biological nanoparticles as nanotherapeutics for tumor immunomodulation DOI Creative Commons

Juwita N. Rahmat,

Jiayi Liu,

Taili Chen

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5862 - 5903

Published: Jan. 1, 2024

Schematic of the immunomodulatory approaches for tipping balance towards anti-cancer immunity. This image was created with BioRender.com.

Language: Английский

Citations

6
Cell Membrane-Coated Nanoparticles for Precision Medicine: A Comprehensive Review of Coating Techniques for Tissue-Specific Therapeutics DOI Open Access
Andrés Fernández-Borbolla, Lorena García‐Hevia, Mónica L. Fanárraga

et al.

Published: Feb. 2, 2024

Nanoencapsulation has emerged as a recent improvement in the delivery of drugs, offering and improving stability bioavailability, allowing for controlled targeted substances to specific cells or tissues. However, traditional nanoparticle faces challenges such short circulation time immune recognition. To address these issues, cell membrane-coated nanoparticles have been proposed promising alternative. The production involves three key stages: lysis membrane fragmentation, isolation, coating. Typically, membranes are fragmented using hypotonic combination with homogenization sonication. Subsequent fragments isolated through multiple centrifugation steps. coating can be achieved extrusion, sonication, both methods. This analysis shows absence universally applicable method coating, stages exhibit notable differences their procedures. Here we review ongoing developments approaches that position this technology alternative effective drug many other therapeutic applications.

Language: Английский

Citations

5