Lymphatic system regulation of anti-cancer immunity and metastasis DOI Creative Commons
Pin‐Ji Lei, Cameron Fraser,

Dennis Jones

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

Cancer dissemination to lymph nodes (LN) is associated with a worse prognosis, increased incidence of distant metastases and reduced response therapy. The LN microenvironment puts selective pressure on cancer cells, creating cells that can survive in as well providing survival advantages for metastatic spread. Additionally, the presence leads an immunosuppressive microenvironment, favoring evasion anti-cancer immune surveillance. However, recent studies have also characterized previously unrecognized roles tumor-draining (TDLNs) immunotherapy response, including acting reservoir pre-exhausted CD8+ T stem-like cells. In this review, we will discuss spread through lymphatic system, TDLNs metastasis responses, therapeutic opportunities challenges targeting metastasis.

Language: Английский

Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives DOI Creative Commons
Eliana B. Souto, Cristina Blanco-Llamero, Karolline Krambeck

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 180, P. 1 - 17

Published: April 10, 2024

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.

Language: Английский

Citations

34
Cancer vaccines: platforms and current progress DOI Creative Commons
Wanting Lei, Kexun Zhou,

Ye Lei

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 10, 2025

Abstract Cancer vaccines, crucial in the immunotherapeutic landscape, are bifurcated into preventive and therapeutic types, both integral to combating oncogenesis. Preventive cancer like those against HPV HBV, reduce incidence of virus-associated cancers, while vaccines aim activate dendritic cells cytotoxic T lymphocytes for durable anti-tumor immunity. Recent advancements vaccine platforms, such as synthetic peptides, mRNA, DNA, cellular, nano-vaccines, have enhanced antigen presentation immune activation. Despite US Food Drug Administration approval several full potential remains unrealized due challenges selection, tumor-mediated immunosuppression, optimization delivery systems. This review provides a comprehensive analysis aims implications vaccine, innovative discovery neoantigens enhancing specificity, latest strides platforms. It also critically evaluates role adjuvants immunogenicity mitigating immunosuppressive tumor microenvironment. The further examines synergistic combining with other therapies, chemotherapy, radiotherapy, checkpoint inhibitors, improve outcomes. Overcoming barriers effective identification, microenvironments, adverse effects is critical advancing development. By addressing these challenges, can offer significant improvements patient outcomes broaden scope personalized immunotherapy.

Language: Английский

Citations

2
Lymphoid organ-targeted nanomaterials for immunomodulation of cancer, inflammation, and beyond DOI
Jessica C. Hsu, Peng Liu, Yangmeihui Song

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(15), P. 7657 - 7680

Published: Jan. 1, 2024

Nanomaterials exhibit significant potential for stimulating immune responses, offering both local and systemic modulation across a variety of diseases. The lymphoid organs, such as the spleen lymph nodes, are home to various cells, including monocytes dendritic which contribute progression prevention/treatment Consequently, many nanomaterial formulations being rationally designed target these organs engage with specific cell types, thereby inducing therapeutic protective effects. In this review, we explore crucial cellular interactions processes involved in regulation highlight innovative nano-based immunomodulatory approaches. We outline essential considerations design an emphasis on their impact biological interactions, targeting capabilities, treatment efficacy. Through selected examples, illustrate strategic therapeutically active nanomaterials subsequent immunomodulation infection resistance, inflammation suppression, self-antigen tolerance, cancer immunotherapy. Additionally, address current challenges, discuss emerging topics, share our outlook future developments field.

Language: Английский

Citations

10
Identification of PLAC1 as a prognostic biomarker and molecular target in clear cell renal cell carcinoma DOI Creative Commons
Ying Kong,

Zongming Jia,

Yizhang Sun

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: 127, P. 111606 - 111606

Published: Jan. 13, 2025

Clear cell renal carcinoma (ccRCC) is a common clinical tumor of the urinary system. The lack effective diagnostic and treatment options poses serious challenge to treatment. Therefore, identifying molecular targets has become one potential means treat this disease. Firstly, analysis TCGA database found that PLAC1 was abnormally highly expressed in ccRCC negatively correlated with patient prognosis. Western blotting immunofluorescence experiments further verified patients, knockdown inhibited development vitro. Last, high-throughput virtual screening technology (HTVS) performed identify two inhibitors ，AmB Cana, which were able reduce expression progression ccRCC. In conclusion, current investigation indicated could serve as prognostic biomarker, AmB Cana inhibit by reducing PLAC1, making it therapeutic option for

Language: Английский

Citations

1
Components, Formulations, Deliveries, and Combinations of Tumor Vaccines DOI
Tengfei Liu,

Wenyan Yao,

Wenyu Sun

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 18801 - 18833

Published: July 9, 2024

Tumor vaccines, an important part of immunotherapy, prevent cancer or kill existing tumor cells by activating restoring the body's own immune system. Currently, various formulations vaccines have been developed, including cell membrane DNA mRNA polypeptide virus-vectored and tumor-in-situ vaccines. There are also multiple delivery systems for such as liposomes, vesicles, viruses, exosomes, emulsions. In addition, to decrease risk escape tolerance that may exist with a single vaccine, combination therapy radiotherapy, chemotherapy, checkpoint inhibitors, cytokines, CAR-T therapy, photoimmunotherapy is effective strategy. Given critical role in here, we look back history discuss antigens, adjuvants, formulations, systems, mechanisms, future directions

Language: Английский

Citations

7
Personalized Nanovaccines Enhance Lymph Node Accumulation and Reprogram the Tumor Microenvironment for Improved Photodynamic Immunotherapy DOI
Ruoning Wang, Jinge Li, Xiaohong Wang

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(24), P. 7432 - 7442

Published: May 20, 2024

Tumor immunotherapy has emerged as an efficacious therapeutic approach that mobilizes the patient's immune system to achieve durable tumor suppression. Here, we design a photodynamic therapy-motivated nanovaccine (Dex-HDL/ALA-Fe

Language: Английский

Citations

6
Navigating the intricate in-vivo journey of lipid nanoparticles tailored for the targeted delivery of RNA therapeutics: a quality-by-design approach DOI Creative Commons

Ehsan Bitaraf Haghighi,

Samira Sadat Abolmaali, Ali Dehshahri

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for treating diverse diseases. However, their potential is commonly hindered by vulnerability to degradation poor cellular uptake, requiring effective delivery systems. Lipid nanoparticles (LNPs) have emerged a leading choice in vivo delivery, offering protection against degradation, enhanced facilitation of endosomal escape. LNPs encounter numerous challenges targeted vivo, demanding advanced particle engineering, surface functionalization with targeting ligands, profound comprehension the biological milieu which they function. This review explores structural physicochemical characteristics LNPs, in-vivo fate, customization therapeutics. We highlight quality-by-design (QbD) approach beyond liver, focusing on biodistribution, immunogenicity, toxicity. In addition, we explored current strategies associated ensuring repeated-dose efficacy, safety, tissue-specific gene delivery. Furthermore, provide insights into clinical applications various classes diseases finally prospects

Language: Английский

Citations

6
Recent Progress in Cancer Vaccines and Nanovaccines DOI
Kishwor Poudel,

Tulasi Vithiananthan,

Jong Oh Kim

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122856 - 122856

Published: Sept. 28, 2024

Language: Английский

Citations

4
Engineered Cancer Nanovaccines: A New Frontier in Cancer Therapy DOI Creative Commons
Yijie Wang,

Congrui Liu,

Chao Fang

et al.

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Sept. 30, 2024

Abstract Vaccinations are essential for preventing and treating disease, especially cancer nanovaccines, which have gained considerable interest recently their strong anti-tumor immune capabilities. Vaccines can prompt the system to generate antibodies activate various cells, leading a response against tumor tissues reducing negative effects recurrence risks of traditional chemotherapy surgery. To enhance flexibility targeting vaccines, nanovaccines utilize nanotechnology encapsulate or carry antigens at nanoscale level, enabling more controlled precise drug delivery responses. Cancer function by encapsulating tumor-specific tumor-associated within nanomaterials. The small size these nanomaterials allows T dendritic thereby eliciting potent response. In this paper, we focus on classification carriers roles different target clinically tested discussing strategies effectively inducing cytotoxic lymphocytes responses optimizing antigen presentation, while also looking ahead translational challenges moving from animal experiments clinical trials.

Language: Английский

Citations

4
Application of Nanomaterials in Early Imaging and Advanced Treatment of Atherosclerosis DOI Creative Commons
Qun Zhou, Yujie Wang, Guangxiang Si

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(2), P. 51 - 76

Published: Jan. 21, 2025

Atherosclerosis (AS) is a serious disease that poses significant threat to the global population. In this review, we analyze development of AS from multiple perspectives, aiming elucidate its molecular mechanisms. We also focus on imaging techniques and therapeutic approaches, highlighting crucial role nanomaterials in both therapy for AS. By leveraging their compatibility targeting capabilities, can be integrated with traditional medical agents achieve targeted drug delivery, controlled release, precise localization atherosclerotic plaques.

Language: Английский

Citations

0