Potentiating dual-directional immunometabolic regulation with nanomedicine to enhance anti-tumor immunotherapy following incomplete photothermal ablation DOI Creative Commons
Qinqin Jiang, Bin Qiao, Jun Zheng

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 24, 2024

Abstract Photothermal therapy (PTT) is a promising cancer treatment method due to its ability induce tumor-specific T cell responses and enhance therapeutic outcomes. However, incomplete PTT can leave residual tumors that often lead new metastases decreased patient survival in clinical scenarios. This primarily the release of ATP, damage-associated molecular pattern quickly transforms into immunosuppressive metabolite adenosine by CD39, prevalent tumor microenvironment, thus promoting immune evasion. study presents photothermal nanomedicine fabricated electrostatic adsorption among Fe-doped polydiaminopyridine (Fe-PDAP), indocyanine green (ICG), CD39 inhibitor sodium polyoxotungstate (POM-1). The constructed Fe-PDAP@ICG@POM-1 (FIP) immunogenic death when exposed near-infrared laser. Significantly, it inhibit ATP-adenosine pathway dual-directional immunometabolic regulation, resulting increased ATP levels synthesis, which ultimately reverses microenvironment increases susceptibility checkpoint blockade (aPD-1) therapy. With aid aPD-1, regulation strategy mediated FIP effectively suppress/eradicate primary distant evoke long-term solid immunological memory. an control offer salvage option for treating following PTT.

Language: Английский

Applications of Aggregation-Induced Emission Materials in Immunology: From Diagnostics to Immunotherapy DOI Creative Commons

Langyi Yang,

Ling‐Hong Xiong, Xuewen He

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Aggregation-induced emission (AIE) materials, due to their unique ability significantly enhance optical in aggregated states, have demonstrated vast potential immunology, particularly early disease diagnosis and immunotherapy. AIE materials can serve as highly efficient fluorescent probes for biomarker detection, providing critical insights diagnosis. Additionally, they act cancer vaccines, enhancing the effectiveness of immunotherapy through photodynamic therapy, photothermal or activation immune cells. This review highlights applications focusing on recent advancements diagnostics while also discussing challenges face directions future development.

Language: Английский

Citations

0
Functionalization of Nucleic Acid Molecular Machines under Physiological Conditions: A Review DOI
Mo Zhou,

Hongzhen Peng,

Shihua Luo

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

In-situ fabrication of nucleic acid molecular machines in biological environments is desirable for smart theranostic applications. However, given the complex nature environments, integration multiple functional modules into a coordinated machine remains challenging. Recent advances nanotechnology offer solutions to these challenges. Here, we outline design principles acid–based tailored physiological conditions, drawing on recent examples. We review cutting-edge technologies that facilitate their functionalization settings, particularly presynthesis modifications using unnatural bases and postsynthesis via bioorthogonal chemistry noncovalent interactions. discuss advantages limitations suggest future directions overcome existing

Language: Английский

Citations

0
Self-degradable nanoparticles hybrid hydrogel with cascade thermal control and spontaneous ion release for complex bone defect regeneration DOI
Shuhan Yang, Zheng Zheng, Min Zhang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162653 - 162653

Published: April 1, 2025

Language: Английский

Citations

0
Crystal Violet-Loaded Bi(III)-Based Metal–Organic Framework Boosting Enhanced Photothermal Effect for Breast Cancer Treatment DOI
Xue Wu, Shun Yang, Mingyu Li

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Recently, metal-organic frameworks (MOFs) have emerged as promising platforms to fabricate photothermal therapeutic materials cure tumors, but the toxic heavy metals in many MOFs may pose great threats normal cells. In consideration of low toxicity bismuth, herein we made efforts synthesize porous bismuth-based (Bi-MOFs) construct conversion for cancer treatment. By reaction 4,4',4''-tricarboxylic triphenylamine (H3TCA) and Bi(NO3)3 under solvothermal conditions, a Bi-MOF was obtained with formula {[Bi2(TCA)2(H2O)3]·6DMF·21H2O}n (Bi-TCA). Structural analysis revealed that complex Bi-TCA displayed three-dimensional (3D) coordination framework featuring abundant accessible channels cages porosity 73.3% according calculating results PLATON. Due high porosity, could effectively encapsulate dye crystal violet (CV) into voids resulting dye-loaded composite CV@Bi-TCA exhibited extended red-shifted light-absorbing property enhanced capability 455 nm laser irradiation. Further anticancer experiments demonstrated efficiently inhibit growth breast cells both vitro vivo This work promote investigations on low-toxicity Bi-MOFs therapy.

Language: Английский

Citations

0
Protein click chemistry and its potential for medical applications DOI
Ahmad Amiri, Sedigheh Abedanzadeh, Bagher Davaeil

et al.

Quarterly Reviews of Biophysics, Journal Year: 2024, Volume and Issue: 57

Published: Jan. 1, 2024

Abstract A revolution in chemical biology occurred with the introduction of click chemistry. Click chemistry plays an important role protein modifications, providing specific, sensitive, rapid, and easy-to-handle methods. Under physiological conditions, often overlaps bioorthogonal chemistry, defined as reactions that occur rapidly selectively without interfering biological processes. is used for posttranslational modification proteins based on covalent bond formations. With contribution reactions, selective would be developed, representing alternative to other technologies preparing new or enzymes studying specific functions different Click-modified have potential diverse applications such imaging, labeling, sensing, drug design, enzyme technology. Due promising disease diagnosis therapy, this review aims highlight growing strategies over last two decades, a special emphasis medicinal applications.

Language: Английский

Citations

3
Laser-activable murine ferritin nanocage for chemo-photothermal therapy of colorectal cancer DOI Creative Commons

Jin-mei Cheng,

Jiaxin Li, Qilin Yu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 29, 2024

Abstract Chemotherapy, as a conventional strategy for tumor therapy, often leads to unsatisfied therapeutic effect due the multi-drug resistance and serious side effects. Herein, we genetically engineered thermal-responsive murine Ferritin (mHFn) specifically deliver mitoxantrone (MTO, chemotherapeutic photothermal agent) tissue chemotherapy combined therapy of colorectal cancer, thanks high affinity mHFn transferrin receptor that highly expressed on cells. The thermal-sensitive channels allowed effective encapsulation MTO in vitro laser-controlled release vivo. Upon irradiation with 660 nm laser, raised temperature triggered opening channel nanocage, resulting controlled rapid MTO. Consequently, significant amount reactive oxygen species was generated, causing mitochondrial collapse cell death. photothermal-sensitive release, low systemic cytotoxicity, excellent synergistic eradication ability vivo made mHFn@MTO promising candidate chemo-photothermal combination against cancer. Graphical

Language: Английский

Citations

3
Manganese-doped liquid metal nanoplatforms for cellular uptake and glutathione depletion-enhanced photothermal and chemodynamic combination tumor therapy DOI
Shuai Wang, Yang Zou, Liefeng Hu

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

3
Recent Advances in Aggregation-Induced Emission Bioconjugates DOI
Guiquan Zhang,

Daming Zhou,

Rong Hu

et al.

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Fluorescence imaging technology is playing increasing roles in modern personalized and precision medicine. Thanks to their excellent photophysical properties, organic luminogens featuring aggregation-induced emission (AIE) characteristics (AIEgens) have attracted considerable attention over the past two decades. Because of superior biocompatibility, ease processing functionalization, water solubility, high responsiveness, exceptional signal-to-noise ratio (SNR) for biotargets, AIE bioconjugates, formed by covalently linking AIEgens with biomolecules, emerged as an ideal candidate bioapplications. In this review, we summarize progress preparation, application bioconjugates last five years. Moreover, challenges opportunities are also briefly discussed.

Language: Английский

Citations

0
Construction of multifunctional nanozymes with amplified immunogenic death effect as a long-term anti-tumor nanoplatform DOI

Kexin Luo,

Sasha You,

Jingyu Chen

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214336 - 214336

Published: May 1, 2025

Language: Английский

Citations

0
Metal‐free click and bioorthogonal reactions of aggregation‐induced emission probes for lighting up living systems DOI
S. Segawa, Xuewen He, Ben Zhong Tang

et al.

Luminescence, Journal Year: 2023, Volume and Issue: 39(1)

Published: Nov. 21, 2023

Abstract In 2002, two transformative research paradigms emerged: ‘click chemistry’ and ‘aggregation‐induced emission (AIE),’ both leaving significant impacts on early 21st‐century academia. Click chemistry, which describes the straightforward reliable reactions for linking building blocks, has simplified complex molecular syntheses functionalization, propelling advancements in polymer, material, life science. particular, nontoxic, metal‐free click involving abiotic functional groups have matured into bioorthogonal reactions. These are organic ligations capable of selective efficient operations even congested living systems, therefore enabling vitro to vivo biomolecular labelling. Concurrently, AIE, a fluorogenic phenomenon twisted π‐conjugated compounds upon aggregation, offered profound insight solid‐state photophysics promoted creation aggregate materials. The inherent fluorogenicity aggregate‐emission properties AIE luminogens found extensive application biological imaging, characterized by their high‐contrast photostable fluorescent signals. As such, convergence these domains yield labelling with excellent fluorescence images is an anticipated progression recent science research. this review, we intend showcase synergetic applications probes or reactions, highlighting achievements unexplored avenues promising field.

Language: Английский

Citations

7