Safe transportation and targeted destruction: Albumin encapsulated aggregation‐induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage‐triggered pyroptosis DOI Creative Commons
Juanmei Cao, Yong Qu, Shaojie Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Abstract Photodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because of their normal tissue distribution and reduction antitumor resulting from aggregation‐caused quenching effects. The present study developed novel nano‐formulated aggregation‐induced emission (AIE)‐characteristic PS, nab‐TTVPHE, which composed human serum albumin carrier TTVPHE therapeutic agent, more effective cancer with lower Notably, the reactive oxygen species generated by were shielded nanoaggregate structure, photodynamic activity was after nanostructure dissociation. Nab‐TTVPHE actively internalized tumor cells via secreted protein, acidic rich cysteine released to form nanoaggregates. accumulated mitochondria, where it triggered mitochondrial damage under light irradiation its induced pyroptosis caspase‐3/gasdermin E (GSDME) signaling pathway kill cells. Therefore, this AIE‐characteristic PS provides an innovative strategy effect ability boost potential immunity GSDME‐mediated pyroptosis.

Language: Английский

Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy DOI Creative Commons

Zeyan Zhuang,

Jianqing Li,

Pingchuan Shen

et al.

Aggregate, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 10, 2024

Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.

Language: Английский

Citations

38
Zwitterionic Photosensitizer‐Assembled Nanocluster Produces Efficient Photogenerated Radicals via Autoionization for Superior Antibacterial Photodynamic Therapy DOI Open Access

Ping He,

Mingxuan Jia,

Linfang Yang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Photodynamic therapy (PDT) holds significant promise for antibacterial treatment, with its potential markedly amplified when using Type I photosensitizers (PSs). However, developing PSs remains a challenge due to lack of reliable design strategy. Herein, PS nanocluster is developed via self‐assembly zwitterionic small molecule (C3TH) superior PDT in vivo. Mechanism studies demonstrate that unique cross‐arranged C3TH within not only shortens intermolecular distance but also inhibits electronic‐vibrational coupling, thus facilitating photoinduced electron transfer form radical cation and anion autoionization reaction. Subsequently, these highly oxidizing or reducing radicals engage cascade photoredox generate efficient ·OH O 2 ‾·. As result, nanoclusters achieve 97.6% efficacy against MRSA at an ultralow dose, surpassing the commercial antibiotic Vancomycin by more than 8.8‐fold. These findings deepen understanding PDT, providing novel strategy PSs.

Language: Английский

Citations

2
Membrane-anchoring clickable Iridium(III) nanosonosensitizer in situ evokes PANoptosis for augmented tumor sono-immunotherapy DOI
Xiaoyu Xu,

Shayibai Shabiti,

Xu Zhang

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 56, P. 102270 - 102270

Published: April 15, 2024

Language: Английский

Citations

15
Manipulation of Nonradiative Process Based on the Aggregation Microenvironment to Customize Excited-State Energy Conversion DOI
Guan Wang, Ben Zhong Tang, Xinggui Gu

et al.

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(9), P. 1360 - 1371

Published: April 26, 2024

ConspectusNonradiative processes with the determined role in excited-state energy conversion, such as internal conversion (IC), vibrational relaxation (VR), intersystem crossing (ISC), and or electron transfer (ET eT), have exerted a crucial effect on biological functions nature. Inspired by these, nonradiative process manipulation has been extensively utilized to develop organic functional materials fields of biomedicine. Therefore, comprehensive knowledge effective sophisticated for achieving high-efficiency are quintessential. So far, many strategies focused molecular engineering demonstrated tremendous potential manipulating tailor conversion. Besides, aggregation considerably affects due their ultrasensitivity, thus providing us another essential approach processes, famous aggregation-induced emission. However, weak interactions established upon aggregation, namely, microenvironment (AME), possess hierarchical, dynamic, systemic characteristics extremely complicated elucidate. Revealing relationship between AME employing it customize would greatly promote advanced utilization, biomedicine, etc., but remain huge challenge. Our group devoted much effort this goal.In Account, we focus our recent developments based AME. First, provide insight into terms its steric electronic regulation, illustrating possibility through modulation. Second, distinct enhanced is crystallization heterogeneous polymerization conduct crystallization-induced reversal from dark bright excited states dynamic hardening-triggered suppression highly efficient luminescence. Meanwhile, promoting ISC stabilizing triplet state also manipulated crystal polymer matrix induce room-temperature phosphorescence. Furthermore, employed exploit photothermy photosensitization reviewed. For photothermal besides weakened promoted motions, new strategy involving introduction diradicals narrow band gap enhance intermolecular put forward facilitate IC VR photosensitization, both rigid regulation electron-rich ISC, ET, eT superior photosensitization. Finally, explore existing challenges future directions modulation customized We hope that Account will be wide interest readers different disciplines.

Language: Английский

Citations

11
Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy DOI
Dongfang Liu,

Mengyun Liang,

Yongyou Tao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122610 - 122610

Published: May 11, 2024

Language: Английский

Citations

11
Calcination-Induced Tight Nano-Heterointerface for Highly Effective Eradication of Rib Fracture-Related Infection by Near-Infrared Irradiation DOI

Yingde Xu,

Honggang Xia,

Chaofeng Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Rib fracture-related infection is a challenging complication of thoracic trauma due to the difficulty treating it with antibiotics alone and need for second operation remove infected fixator sterilize surrounding tissue. In this study, inspired by photocatalytic performance ion release from silver-based materials, including Ag3PO4 Ag2S, hybrid Ag3PO4-Ag2S heterojunction was prepared based on in situ anion exchange one-step calcination process design nonantibiotic coating aimed at preventing rib short-term 808 nm near-infrared irradiation. Calcination 250 °C enhanced inductive effect phosphate radical led formation tight nanoheterogeneous interface between thereby promoting interfacial electron transfer reducing recombination photogenerated carriers. The result improved photodynamic coating. Moreover, metal-Ag3PO4-Ag2S had significant photothermal released only small amount Ag+. synergy endowed high antibacterial efficacy, eliminating 99.90 ± 0.05 99.95 0.03% Staphylococcus aureus Escherichia coli, respectively, after 15 min NIR irradiation vitro, 99.66 0.13% vivo. This biocompatible exhibited superb efficacy associated inflammation.

Language: Английский

Citations

1
Donor Modulation Brings All-In-One Phototheranostics for NIR-II Imaging-Guided Type-I Photodynamic/Photothermal Synergistic Cancer Therapy DOI Creative Commons
Yuxin Ren, Xinyi Zhang, Ling Li

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel all-in-one phototheranostics OTAB was synthesized by modifying the donor and regulating band gap for NIR-II imaging-guided synergistic type-I PDT/PTT therapy.

Language: Английский

Citations

1
Atomic Engineering and Aggregation Effect to Regulate Synergistically Type I Reactive Oxygen Species of AIE‐Active Deep Red/Near Infrared Red Photosensitizer DOI Open Access

Y. H. Zheng,

Yin Li, Xue Bai

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract “Molecular science” has long been regarded as the golden rule to guide design of organic materials’ performances in past many years, but some interesting phenomena conventional aggregation‐caused fluorescence quenching and new aggregation‐induced emission reflect that properties would be changed from “molecule” “aggregate”. Therefore, “molecular theory faces certain limitations regulating performance materials at aggregation. In this work, it is discovered photosensitizer's contain reactive oxygen species, which could affected by changing molecular atoms aggregation form. The introduction selenium redshift improve species (ROS) efficiency. addition atomic effect, ROS efficiency photosensitizers after coating a polymeric shell, is, production type II singlet ( 1 O 2 ) suppressed, while I superoxide anion (O −• improved. This work discovers are relevant effect discussing deeply influence mechanism, important research significance for modulating precisely promoting development photodynamic therapy.

Language: Английский

Citations

1
Mechanistic analysis of viscosity-sensitive fluorescent probes for applications in diabetes detection DOI

M.M. Sreejaya,

Vineeth M. Pillai,

A. Ayesha

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(12), P. 2917 - 2937

Published: Jan. 1, 2024

This review focuses on fluorescence mechanisms for viscosity responsiveness, highlighting some important probes like coumarin, BODIPY, and xanthene as well the application of these viscosity-sensitive successful diabetes detection.

Language: Английский

Citations

7
Anthraquinone-Centered Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Tumor-Targeted Two-Photon Photodynamic Therapy DOI
Wenguang Zhang, Xue Li,

Miaomiao Kang

et al.

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(6), P. 2174 - 2185

Published: May 6, 2024

Exploring advanced photodynamic strategies to surmount the firm reliance on oxygen and limited penetration depth of excitation light is great significance in tumor therapy. Herein, a two-photon excitable type I photosensitizer with aggregation-induced emission characteristics, namely tBuT2AQ, rationally designed by simply equipping an anthraquinone (AQ) acceptor rotor-type electron-donating triphenylamine derivatives. The AQ moiety good electron-withdrawing ability significant spin–orbit coupling effect could facilitate generation triplet excitons triggering multichannel intersystem crossing. These further undergo electron transfer processes enable massive production reactive species because redox cycling behaviors mediated carbonyl groups moiety. Moreover, planar structure beneficial for allows deep into biological tissues. After being formulated nanoparticles acid-responsive charge-reversible polymers, tBuT2AQ can be accumulated at sites efficiently performs highly effective treatment.

Language: Английский

Citations

7