Safe transportation and targeted destruction: Albumin encapsulated aggregation‐induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage‐triggered pyroptosis DOI Creative Commons
Juanmei Cao, Yong Qu, Shaojie Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Abstract Photodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because of their normal tissue distribution and reduction antitumor resulting from aggregation‐caused quenching effects. The present study developed novel nano‐formulated aggregation‐induced emission (AIE)‐characteristic PS, nab‐TTVPHE, which composed human serum albumin carrier TTVPHE therapeutic agent, more effective cancer with lower Notably, the reactive oxygen species generated by were shielded nanoaggregate structure, photodynamic activity was after nanostructure dissociation. Nab‐TTVPHE actively internalized tumor cells via secreted protein, acidic rich cysteine released to form nanoaggregates. accumulated mitochondria, where it triggered mitochondrial damage under light irradiation its induced pyroptosis caspase‐3/gasdermin E (GSDME) signaling pathway kill cells. Therefore, this AIE‐characteristic PS provides an innovative strategy effect ability boost potential immunity GSDME‐mediated pyroptosis.

Language: Английский

An Albumin‐Photosensitizer Supramolecular Assembly with Type I ROS‐Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy DOI Creative Commons
Jingtian Zhang,

Di Jiao,

Xinwen Qi

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness hypoxic solid tumor is limited by the oxygen‐dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, study reports a supramolecular photosensitizer, BSA@TPE‐BT‐SCT NPs, through encapsulating aggregation‐enhanced emission photosensitizer bovine serum albumin (BSA) to significantly enhance ROS, particularly less oxygen‐dependent I ROS for photodynamic immunotherapy. The abundant generated NPs induce multiple forms programmed cell death, including apoptosis, pyroptosis, ferroptosis. These multifaceted deaths synergistically facilitate release damage‐associated molecular patterns antitumor cytokines, thereby provoking robust immunity. Both vitro vivo experiments confirmed that elicited immunogenic dendritic maturation, activate T cell, reduce myeloid‐derived suppressor cells, leading inhibition both primary distant tumors. Additionally, BSA@TPE‐BT‐SCP also exhibited excellent performance humanized mice model, evidenced reduction senescent cells among these activated cells. findings advance development photosensitizers unveil important role enhancing immunogenicity.

Language: Английский

Citations

0
Enhanced efficiency and selectivity in reactive oxygen species generation using thiazolo[5,4-d]thiazole-based supramolecular photosensitizers DOI
Guang Wang,

Tongfei Qi,

Xianjun Yin

et al.

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
Construction of supramolecular dimer photosensitizers based on triphenylamine derivatives and cucurbit[8]uril for photocatalysis DOI
Xinlong Li,

Cheng Dongliang,

Kai‐Kai Niu

et al.

Journal of Materials Chemistry A, Journal Year: 2023, Volume and Issue: 11(45), P. 24911 - 24917

Published: Jan. 1, 2023

We have designed and constructed supramolecular dimers between triphenylamine derivatives with AIE properties CB[8] through host–guest interactions, which can be used as photosensitizers for photooxidation reactions of thioanisole.

Language: Английский

Citations

10
A Heterocyclic Strategy for Regulating the Proportion of Type I and Type II of Photodynamic Therapy DOI
Hui Tang, Ning Ma, Xiaochun Liu

et al.

Materials Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 8(17), P. 2866 - 2873

Published: Jan. 1, 2024

(Yield of ROS) TPO > (yield TPS TPP , (proportion type I .

Language: Английский

Citations

3
Safe transportation and targeted destruction: Albumin encapsulated aggregation‐induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage‐triggered pyroptosis DOI Creative Commons
Juanmei Cao, Yong Qu, Shaojie Zhu

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Abstract Photodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because of their normal tissue distribution and reduction antitumor resulting from aggregation‐caused quenching effects. The present study developed novel nano‐formulated aggregation‐induced emission (AIE)‐characteristic PS, nab‐TTVPHE, which composed human serum albumin carrier TTVPHE therapeutic agent, more effective cancer with lower Notably, the reactive oxygen species generated by were shielded nanoaggregate structure, photodynamic activity was after nanostructure dissociation. Nab‐TTVPHE actively internalized tumor cells via secreted protein, acidic rich cysteine released to form nanoaggregates. accumulated mitochondria, where it triggered mitochondrial damage under light irradiation its induced pyroptosis caspase‐3/gasdermin E (GSDME) signaling pathway kill cells. Therefore, this AIE‐characteristic PS provides an innovative strategy effect ability boost potential immunity GSDME‐mediated pyroptosis.

Language: Английский

Citations

3