Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157911 - 157911
Published: Nov. 1, 2024
Language: Английский
JACS Au, Journal Year: 2025, Volume and Issue: 5(2), P. 486 - 520
Published: Feb. 10, 2025
Tetrahedral framework nucleic acids (tFNAs) represent a promising advancement in acid nanotechnology due to their unique structural properties, high biocompatibility, and multifaceted biomedical applications. Constructed through one-pot annealing method, four single-stranded DNAs self-assemble into stable, three-dimensional tetrahedral nanostructures with enhanced mechanical robustness physiological stability, resisting enzymatic degradation. Their ability permeate mammalian cells without transfection agents, coupled modifiable surfaces, positions tFNAs as versatile carriers for drug gene delivery systems. The tFNA-based platforms exhibit superior therapeutic efficacy, including antioxidative anti-inflammatory effects, alongside efficient cellular uptake tissue penetration. These features underpin role precision medicine, enabling targeted of diverse agents such synthetic compounds, peptides, acids. Additionally, demonstrate significant potential regenerative immune modulation, antibacterial strategies, oncology. By addressing challenges translational integration, stand poised accelerate the development research clinical applications, fostering novel therapies enhancing outcomes across wide spectrum diseases. This Perspective thoroughly details attributes applications critically evaluates tFNAs' potential, outlining inherent implementation exploring solutions these obstacles.
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: April 1, 2024
Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical
Language: Английский
Citations
10
Cell Proliferation, Journal Year: 2024, Volume and Issue: 57(6)
Published: Jan. 28, 2024
Abstract Clinicians and researchers have always faced challenges in performing surgery for rotator cuff tears (RCT) due to the intricate nature of tendon‐bone gradient limited long‐term effectiveness. At same time, occurrence an inflammatory microenvironment further aggravates tissue damage, which has a negative impact on regeneration process mesenchymal stem cells (MSCs) eventually leads production scar tissue. Tetrahedral framework nucleic acids (tFNAs), novel nanomaterials, shown great potential biomedicine their strong biocompatibility, excellent cellular internalisation ability, unparalleled programmability. The objective this research was examine if tFNAs positive effect after RCTs. Experiments conducted controlled environment demonstrated that hindered assembly inflammasomes macrophages, resulting decrease release factors. Next, were exert protective osteogenic chondrogenic differentiation bone marrow MSCs under conditions. vitro results also regulatory tendon‐related protein expression levels tenocytes stimulation. Finally, intra‐articular injection into rat RCT model showed improved tendon‐to‐bone healing, suggesting may be promising agents treatment
Language: Английский
Citations
8
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 7269 - 7286
Published: July 8, 2024
Abstract Diabetic peripheral neuropathy (DPN) is caused by several factors, including reactive free oxygen radicals (ROS)-induced excessive Ca 2+ influx. Transient receptor potential (TRP) vanilloid 4 (TRPV4) a member of the -permeable TRP superfamily. Resveratrol (RESV) has been extensively utilized in channel regulation due to its pharmacological properties, which include antioxidant and inhibitory effects. The protective function RESV contribution TRPV4 streptozotocin (STZ)-induced neuropathic pain mice are still unclear. Here, we evaluated effects through modulation on influx, ROS-mediated pain, apoptosis, oxidative damage mouse dorsal root ganglion (DRGs). From 32 mice, four groups were induced: control, RESV, STZ, STZ + RESV. We found that injection reduced changes STZ-induced stimulation TRPV4, turn increased mechanical/thermal cytosolic current density, oxidants (lipid peroxidation, mitochondrial ROS, ROS), apoptotic markers (caspase-3, -8, -9). also STZ-mediated reduction viability DRG amounts glutathione, glutathione peroxidase, vitamin A, β-carotene, E brain, erythrocytes, plasma, liver, kidney. All these findings suggest generates neurotoxicity, apoptosis diabetic mice. On other hand, neurotoxicity downregulation carried out injection. Graphical An overview how resveratrol inhibits modulate diabetes mellitus-induced (DPN). Ruthenium red (RuR) while GSK1016790A (GSK) (ROS) activate it. In mitochondria DRGs, glucose oxidation brought mellitus (STZ) causes an intracellular Zn influx excess dependent TRPV4. administration leads becoming more depolarized (ΔΨm), increase caspases caspase-8, caspase-9) downregulating enzymatic (glutathione GSH-Px) non-enzymatic (GSH), E) antioxidants. mice’s molecular pathways diminished injections. (Increase (↑); diminish (↓))
Language: Английский
Citations
7
Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 385 - 399
Published: July 30, 2024
Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating infections. However, the excess ROS infection site after treatments may cause irreversible damage healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrO
Language: Английский
Citations
7
Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 634 - 648
Published: Aug. 19, 2024
Articular cartilage injury (ACI) remains one of the key challenges in regenerative medicine, as current treatment strategies do not result ideal regeneration hyaline-like cartilage. Enhancing endogenous repair via microRNAs (miRNAs) shows promise a therapy. miRNA-140 and miRNA-455 are two promising candidates for regulating chondrogenic differentiation mesenchymal stem cells (MSCs). In this study, we innovatively synthesized multifunctional tetrahedral framework which nucleic acid (tFNA)-based targeting miRNA codelivery system, named A-T-M, was used. With tFNAs vehicles, miR-140 miR-455 were connected to modified on tFNAs, while Apt19S (a DNA aptamer MSCs) directly integrated into nanocomplex. The relevant results showed that A-T-M efficiently delivered MSCs subsequently regulated MSC through corresponding mechanisms. Interestingly, synergistic effect between revealed. Furthermore, successfully enhanced capacity articular vivo effectively inhibited hypertrophic chondrocyte formation. provides new perspective strategy cartilage, showing strong clinical application value future ACI.
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159618 - 159618
Published: Jan. 15, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 29, 2025
Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote
Language: Английский
Citations
0
Small, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Abstract Type I hypersensitivity reactions are the most common type of and can cause various symptoms in different body systems. Currently, there is no standard treatment for manifestations at sites. To address this challenge, a nanocomposite named tFNAs‐siRNA‐siRNA (TSS) designed based on tetrahedral framework nucleic acids (tFNAs). It loaded with two siRNAs enter through multi‐route administration. In terms realization siRNAs’ functions, TSS successfully delivers them downregulates expression Gab2 Syk, thereby inhibiting migration release granules to extracellular space RBL‐2H3 cells. Interestingly, also exhibits effect hindering Ca 2+ efflux from mitochondria stabilize energy metabolism. passive cutaneous anaphylaxis allergic rhinitis model, shows excellent anti‐allergic ability, demonstrates an advantage intraperitoneal injection, transdermal, transnasal routes sum, offers new therapeutic strategy multiple symptoms, highlighting application potential acids‐based administration delivery system.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Abstract Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes. Although studies have previously investigated metabolic disruptions in nervous system (PNS), exact mechanisms underlying DPN remain largely unknown. Herein, a specific form remodeling involving aberrant ketogenesis within Schwann cells (SCs) streptozotocin (STZ)‐induced type I diabetes mellitus identified. The PNS adapts poorly to such ketogenesis, resulting disrupted energy metabolism, mitochondrial damage, and homeostatic decompensation, ultimately contributing DPN. Additionally, maladaptive highly dependent on cannabinoid type‐1 receptor (CB 1 R)‐Hmgcs2 axis. Silencing CB R reprogrammed metabolism SCs by blocking rebalanced reduced histopathological changes, improved neuropathic symptoms. Moreover, this reprogramming can be induced pharmacologically using JD5037, blocker. These findings revealed new mechanism DPN, promoted as promising therapeutic target for
Language: Английский
Citations
0