Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

Abstract Millions of people worldwide have inflammatory bowel disease (IBD). Self‐driven micro/nanorobots (MNRs) are efficient in the treatment IBD. However, their lack controllability regarding direction motion organism and inability to achieve continuous navigation limits further application. In this study, polydopamine is wrapped around magnetite surface, loaded with an anti‐inflammatory drug resveratrol, pH‐responsive sodium alginate obtain magnetic MNRs. MNRs can be driven by fields directional movement targeted transportation. addition, effectively remove reactive oxygen species from inflammation site, repair intestinal damage, inhibit cellular pathway pro‐inflammatory factors, such as MAPK NF‐κB pathways, restore flora, thereby relieving IBDs. safe effective for vivo IBD proven a promising therapeutic platform. This strategy provides new insights into comprehensive therapy.

Language: Английский

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Amelioration of radiation cystitis by tetrahedral framework nucleic acid nanostructures functionalized with quercetin

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152736 - 152736

Published: June 1, 2024

Language: Английский

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Boronic ester bonding integrated dextran-based hydrogel patch for diabetic peripheral nerve injury treatment

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155336 - 155336

Published: Aug. 30, 2024

Language: Английский

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Mitochondria-targeted delivery of zinc-coordinated resveratrol nanoparticles rescues the osteogenic potential of periodontal ligament stem cells compromised by inflammation for periodontal wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158296 - 158296

Published: Dec. 4, 2024

Language: Английский

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Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Tetrahedral framework nucleic acids (tFNAs) are renowned for their controllable self-assembly, exceptional programmability, and excellent biocompatibility, which have led to widespread application in the biomedical field. Beyond these features, tFNAs demonstrate unique chemical biological properties including high cellular uptake efficiency, structural bio-stability, tissue permeability, derived from distinctive 3D structure. To date, an extensive range of tFNA-based nanostructures intelligently designed developed various applications such as drug delivery, gene therapy, biosensing, engineering, among other emerging fields. In addition role delivery systems, also possess intrinsic that render them highly effective therapeutic agents treatment complex diseases, arthritis, neurodegenerative disorders, cardiovascular diseases. This dual functionality significantly enhances utility research, presenting valuable opportunities development next-generation medical technologies across diverse diagnostic platforms. Consequently, this review comprehensively introduces latest advancements field, with a focus on benefits nanoplatforms, inherent capabilities agents. Furthermore, current limitations, challenges, future perspectives explored.

Language: Английский

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Exploring the potential anti-diabetic peripheral neuropathy mechanisms of Huangqi Guizhi Wuwu Decoction by network pharmacology and molecular docking

Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 40(1)

Published: Nov. 20, 2024

Language: Английский

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Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110241 - 110241

Published: July 1, 2024

Language: Английский

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Biodegradable microspheres via orally deliver celastrol with ameliorated neuropathic pain in diabetes rats

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The treatment of peripheral neuropathy resulting from diabetes primarily emphasizes neurotrophic medications. However, a growing body clinical studies indicates that neuroinflammation plays significant role in the pathogenesis neuropathic pain. This has spurred active exploration strategies leveraging nanomedicine for diseases, aiming superior therapeutic outcomes. In this context, we have developed biodegradable nanoparticles made polylactic-co-glycolic acid, loaded with triptolide (pCel), designed to alleviate somatic cell pain induced by diabetes. Treatment pCel notably reduced levels reactive oxygen species and apoptosis vitro. Furthermore, progression streptozotocin-induced diabetes, characterized elevated renal function indices (blood urea nitrogen, creatinine), liver (bilirubin, alkaline phosphatase) decreased albumin globulin, was mitigated following administration. Importantly, oral significantly inhibited mechanical allodynia activation sciatic glial cells diabetic rats. These findings indicate synthetic, exhibits excellent stability, biocompatibility catalytic activity, making it promising innovative approach management chronic conditions associated neuropathy.

Language: Английский

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Dracocephalum Moldavica L.-Derived carbon dots for effective periodontitis treatment via reprogramming energy metabolism in Macrophages

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 501, P. 157433 - 157433

Published: Nov. 5, 2024

Language: Английский

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The construction of a peptide vaccine with multifunctional DNA tetrahedron exoskeleton

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157911 - 157911

Published: Nov. 1, 2024

Language: Английский

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