Phototherapy in cancer treatment: strategies and challenges DOI Creative Commons

Yeyu Cai,

Tian Chai,

William Nguyen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 2, 2025

Abstract Phototherapy has emerged as a promising modality in cancer treatment, garnering considerable attention for its minimal side effects, exceptional spatial selectivity, and optimal preservation of normal tissue function. This innovative approach primarily encompasses three distinct paradigms: Photodynamic Therapy (PDT), Photothermal (PTT), Photoimmunotherapy (PIT). Each these modalities exerts antitumor effects through unique mechanisms—specifically, the generation reactive oxygen species (ROS), heat, immune responses, respectively. However, significant challenges impede advancement clinical application phototherapy. These include inadequate ROS production rates, subpar photothermal conversion efficiency, difficulties tumor targeting, unfavorable physicochemical properties inherent to traditional phototherapeutic agents (PTs). Additionally, hypoxic microenvironment typical tumors complicates therapeutic efficacy due limited agent penetration deep-seated lesions. To address limitations, ongoing research is fervently exploring solutions. The advantages offered by nano-PTs nanocarrier systems aim enhance approaches’ effectiveness. Strategies such generating situ within or inhibiting mitochondrial respiration while targeting HIF-1α pathway may alleviate hypoxia. Moreover, utilizing self-luminescent materials, near-infrared excitation sources, non-photoactivated sensitizers, wireless light delivery can improve penetration. Furthermore, integrating immunoadjuvants modulating immunosuppressive cell populations deploying checkpoint inhibitors holds promise enhancing immunogenic death PIT. review seeks elucidate fundamental principles biological implications phototherapy discussing dominant mechanisms advanced strategies designed overcome existing challenges—ultimately illuminating pathways future aimed at amplifying this intervention’s efficacy.

Language: Английский

Ternary heterostructure-driven photoinduced electron-hole separation enhanced oxidative stress for triple-negative breast cancer therapy DOI Creative Commons
Shuqing Dong, Yuqi Huang,

Hanrong Yan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 12, 2024

Abstract Zinc oxide nanoparticles (ZnO NPs) stand as among the most significant metal in trigger formation of reactive oxygen species (ROS) and induce apoptosis. Nevertheless, utilization ZnO NPs has been limited by shallowness short-wavelength light constrained production ROS. To overcome these limitations, a strategy involves achieving red shift towards near-infrared (NIR) spectrum, promoting separation restraining recombination electron-hole (e − -h + ) pairs. Herein, hybrid plasmonic system Au@ZnO (AZ) with graphene quantum dots (GQDs) doping (AZG) nano heterostructures is rationally designed for optimal NIR-driven cancer treatment. Significantly, multifold increase ROS generation can be achieved through following creative initiatives: (i) Au nanorods expands photocatalytic capabilities AZG into NIR domain, offering foundation NIR-induced clinical utilization; (ii) elaborate design mesoporous core-shell AZ structures facilitates redistribution pairs; (iii) incorporation GQDs structure could efficiently restrain e (iv) Modification hyaluronic acid (HA) enhance CD44 receptor mediated targeted triple-negative breast (TNBC). In addition, introduced NRs present catalysts enhancing photothermal therapy (PTT), effectively inducing apoptosis tumor cells. The resulting HA-modified (AZGH) exhibits efficient hot electron injection separation, affording unparalleled convenience enabling PDT treanment. As result, our well-designed AZGH photosensitizers exhibit excellent efficacy.

Language: Английский

Citations

6
Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies DOI Creative Commons
Bin Gu, Qin Zhao, Yiran Ao

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1057 - 1057

Published: Aug. 25, 2024

In recent decades, immunotherapy has been considered a promising treatment approach. The modulatable enhancement or attenuation of the body's immune response can effectively suppress tumors. However, challenges persist in clinical applications due to lack precision antigen presentation cells, escape mechanisms, and immunotherapy-mediated side effects. As potential delivery system for drugs immunomodulators, mesoporous silica attracted extensive attention recently. Mesoporous nanoparticles (MSNs) possess high porosity, large specific surface area, excellent biocompatibility, facile modifiability, making them suitable as multifunctional carriers immunotherapy. This article summarizes latest advancements application MSNs cancer immunotherapy, aiming stimulate further exploration immunomodulatory mechanisms development immunotherapeutics based on MSNs.

Language: Английский

Citations

5
Degradable bifunctional phototherapy composites based on upconversion nanoparticle-metal phenolic network for multimodal tumor therapy in the near-infrared biowindow DOI
Fangfang Liu, Yong Li, Wei Qin

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 663, P. 436 - 448

Published: Feb. 24, 2024

Language: Английский

Citations

4
Thermal Enhancement of Upconversion in Sub‐10 nm Yb3+/Er3+/Na+ Tridoped Cs2ZrF6 Nanocrystals for Ratiometric Temperature Sensing DOI

Changhe Hu,

X.G. Li,

Wenfeng Xie

et al.

Advanced Optical Materials, Journal Year: 2024, Volume and Issue: 12(18)

Published: March 18, 2024

Abstract Alkaline zirconium fluorides (A x Zr y F x+y , A = Li, Na, and K), featuring unique crystallographic structures, have recently emerged as a class of attractive hosts for fabricating lanthanide (Ln 3+ )‐doped upconversion nanocrystals (UCNCs) that exhibited distinct morphology, luminescence (UCL) performance, physicochemical property. In this paper, the first time controlled preparation Yb /Er ‐doped UCNCs is reported based on trigonal Cs 2 ZrF 6 host, leading to tunable morphology size resulting by varying reaction temperature time. By further incorporating Na + ions into crystal lattice, sub‐10 nm /Na tridoped with highly improved crystallinity thus greatly enhanced UCL intensity are obtained. Moreover, these display abnormal thermal enhancement over range from 333 493 K, enabling fabrication supersensitive luminescent nanothermometers sensing. Based ratio two nonthermally coupled levels (i.e., 4 9/2 H 11/2 ) Er as‐prepared :Yb/Er/Na exhibit an extremely large absolute sensitivity 177.3% K −1 considerably high relative 1.52% at K. These results unambiguously demonstrate suitable host material preparing small‐sized Ln nanothermometer high‐performance ratiometric

Language: Английский

Citations

4
Prussian blue-decorated indocyanine green-loaded mesoporous silica nanohybrid for synergistic photothermal-photodynamic-chemodynamic therapy against methicillin-resistant Staphylococcus aureus DOI

Chenyang Qi,

Guitao Tan,

Haonan Hu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 241, P. 114065 - 114065

Published: June 27, 2024

Language: Английский

Citations

4
Silica nanoparticles in medicine: overcoming pathologies through advanced drug delivery, diagnostics, and therapeutic strategies DOI Open Access

Carmen-Larisa Nicolae,

Diana-Cristina Pîrvulescu,

Alexandru Mihai Antohi

et al.

Romanian Journal of Morphology and Embryology, Journal Year: 2024, Volume and Issue: 65(2), P. 173 - 184

Published: July 15, 2024

Over the last decades, silica nanoparticles (SiNPs) have been studied for their applications in biomedicine as an alternative used conventional diagnostics and treatments. Since properties can be modified adjusted desired use, they many different potential medicine: diagnosis because of ability to loaded with dyes increased selectivity sensitivity, which improve quality diagnostic process. SiNPs functionalized by targeting ligands or molecules detect certain cellular processes biomarkers better precision. Targeted delivery is another fundamental use SiNPs. They could drug systems (DDS) since structure allows loading therapeutic agents other compounds, studies demonstrated biocompatibility. When are DDS, drug’s toxicity off-target effects reduced significantly, treat conditions like cancer neurological diseases even aid regenerative processes, such wound healing bone repair. However, safety concerns must considered before extensively clinical practice NPs cause accumulate at undesired locations. Therefore, overview that medicine, well concerns, will covered this review paper.

Language: Английский

Citations

4
Cu-Doped MnO2 Nanoparticles Loaded with Docetaxel Synergistically Enhance Chemodynamic Therapy through Ferroptosis and Cuproptosis DOI

Lekang Liu,

Mingbo Shao,

Linna Guo

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We have developed an innovative Cu-doped and DTX-loaded Cu-MnO2@DTX@FA (MCDF) nanodrug designed to strategically alter tumor microenvironment (TME) by harnessing the synergistic effects of chemodynamic therapy (CDT), chemotherapeutic agents, induction ferroptosis cuproptosis. The MCDF efficiently degrades, releasing abundant Mn4+, Cu2+, DTX. conversion Cu2+ Cu+ facilitated FDX1 initiates cuproptosis, while, similar Mn2+, reacts with hydrogen peroxide (H2O2) generate hydroxyl radicals (·OH). Mn4+ oxidize glutathione (GSH), significantly depleting GSH levels in cells inactivating GPX4, which further promotes ferroptosis. release intensifies DTX effectively disrupts cell division cycle, thereby inhibiting proliferation spread cells. FA-modified is evade immune detection while selectively targeting tissues, ensuring precision treatment delivery. This cutting-edge material not only provides a multifunctional therapeutic strategy but also sets stage for next generation tumor-targeting nanomedicines.

Language: Английский

Citations

0
Catalase-assembled nanoparticles for PA/CT dual-modality imaging and repair of acute alcoholic gastritis DOI

Hongchang Yu,

Can Chen, Wei Feng

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 169, P. 214181 - 214181

Published: Jan. 9, 2025

Language: Английский

Citations

0
Chlorin e6: a promising photosensitizer of anti-tumor and anti-inflammatory effects in PDT DOI

Hai-Rong Yu,

Ziling Huang,

Jiale Wu

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 29, 2025

Photodynamic therapy (PDT) involves the activation of photosensitizers (PSs) by visible laser light at target site to catalyze production reactive oxygen species, resulting in tumor cell death and blood vessel closure. The efficacy PDT depends on PSs, amount oxygen, intensity excitation laser. PSs have been extensively researched, great efforts made develop an ideal photosensitizer. Chlorin-e6 is FDA-approved second-generation that has attracted widespread research interest medical field, especially with respect antitumor anti-inflammatory activity. possesses advantages a large absorption coefficient, high strength, low residue body, relatively safety thus promising application prospects. Here we review use chlorin-e6 discuss prospects further development this technology.

Language: Английский

Citations

0
Understanding the interplay between pH and charges for theranostic nanomaterials DOI Creative Commons

Valerie Ow,

Qianyu Lin, Joey Hui Min Wong

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Nanotechnology enables targeted theranostics by enhancing imaging and therapy. This review explores advances in pH-induced charge-switchable nanomaterials, their role drug delivery contrast, future directions the field.

Language: Английский

Citations

0