Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(29), P. 11682 - 11689
Published: July 9, 2024
Cell
death
is
a
fundamental
biological
process
with
different
modes
including
apoptosis
and
necrosis.
In
contrast
to
programmed
apoptosis,
necrosis
was
previously
considered
disordered
passive,
but
it
now
being
realized
be
under
regulation
by
certain
pathways.
However,
the
intracellular
dynamics
that
coordinates
cellular
structure
changes
during
remains
unknown,
limiting
our
understanding
of
principles
Here,
we
characterized
spatiotemporal
diffusion
in
cells
undergoing
necrosis,
using
three-dimensional
single-particle
tracking
quantum
dots.
We
found
temporally
increased
rates
necrotic
spatially
enhanced
heterogeneity
cell
periphery,
which
could
attributed
reduced
molecular
crowding
resulting
from
swelling
peripheral
blebbing,
respectively.
Moreover,
transits
strong
anisotropy
nearly
isotropy,
suggesting
remodeling
cytoarchitecture
relieves
axial
constraint
on
Our
results
reveal
remarkable
alterations
biophysical
properties
providing
insight
into
well-organized
nonequilibrium
perspective.
Nano-Micro Letters,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Feb. 6, 2025
Abstract
The
advancement
of
materials
has
played
a
pivotal
role
in
the
human
civilization,
and
emergence
artificial
intelligence
(AI)-empowered
science
heralds
new
era
with
substantial
potential
to
tackle
escalating
challenges
related
energy,
environment,
biomedical
concerns
sustainable
manner.
exploration
development
are
poised
assume
critical
attaining
technologically
advanced
solutions
that
environmentally
friendly,
energy-efficient,
conducive
well-being.
This
review
provides
comprehensive
overview
current
scholarly
progress
intelligence-powered
its
cutting-edge
applications.
We
anticipate
AI
technology
will
be
extensively
utilized
material
research
development,
thereby
expediting
growth
implementation
novel
materials.
serve
as
catalyst
for
innovation,
turn,
advancements
innovation
further
enhance
capabilities
AI-powered
science.
Through
synergistic
collaboration
between
science,
we
stand
realize
future
propelled
by
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(6), P. 4862 - 4870
Published: Jan. 17, 2024
Frequent
outbreaks
of
viral
diseases
have
brought
substantial
negative
impacts
on
society
and
the
economy,
they
are
very
difficult
to
detect,
as
concentration
aerosols
in
air
is
low
composition
complex.
The
traditional
detection
method
manually
collection
re-detection,
being
cumbersome
time-consuming.
Here
we
propose
a
virus
aerosol
based
microfluidic
inertial
separation
spectroscopic
analysis
technology
rapidly
accurately
detect
particles
air.
chip
designed
principles
laminar
flow
characteristics,
resulting
an
average
efficiency
95.99%
for
2
μm
particles.
We
build
composite
spectrometer
platform
capture
spectral
information
dynamically.
By
employing
machine-learning
techniques,
can
classify
different
types
entire
experiment
took
less
than
30
min
compared
with
hours
by
PCR
detection.
Furthermore,
our
model
achieves
accuracy
97.87%
identifying
aerosols,
which
comparable
results
obtained
from
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 17, 2024
As
a
transdermal
drug
delivery
method,
microneedles
offer
minimal
invasiveness,
painlessness,
and
precise
in-situ
treatment.
However,
current
rely
on
passive
diffusion,
leading
to
uncontrollable
penetration.
To
overcome
this,
we
developed
pneumatic
microneedle
patch
that
uses
live
Enterobacter
aerogenes
as
microengines
actively
control
delivery.
These
microbes
generate
gas,
driving
drugs
into
deeper
tissues,
with
adjustable
glucose
concentration
allowing
over
the
process.
Our
results
showed
this
microorganism-powered
system
increases
depth
by
200%,
reaching
up
1000
μm
below
skin.
In
psoriasis
animal
model,
technology
effectively
delivered
calcitriol
subcutaneous
offering
rapid
symptom
relief.
This
innovation
addresses
limitations
of
conventional
microneedles,
enhancing
efficiency,
permeability,
introducing
creative
paradigm
for
on-demand
controlled
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 24, 2024
Organoid
tumor
models
have
emerged
as
a
powerful
tool
in
the
fields
of
biology
and
medicine
such
3D
structures
grown
from
cells
recapitulate
better
characteristics,
making
these
tumoroids
unique
for
personalized
cancer
research.
Assessment
their
functional
behavior,
particularly
protein
secretion,
is
significant
importance
to
provide
comprehensive
insights.
Here,
label-free
spectroscopic
imaging
platform
presented
with
advanced
integrated
optofluidic
nanoplasmonic
biosensor
that
enables
real-time
secretion
analysis
single
tumoroids.
A
novel
two-layer
microwell
design
isolates
tumoroids,
preventing
signal
interference,
microarray
configuration
allows
concurrent
multiple
The
dual
capability
combining
time-lapse
plasmonic
spectroscopy
bright-field
microscopy
facilitates
simultaneous
observation
dynamics,
motility,
morphology.
demonstrated
colorectal
derived
both
cell
lines
patient
samples
investigate
vascular
endothelial
growth
factor
(VEGF-A)
growth,
movement
under
various
conditions,
including
normoxia,
hypoxia,
drug
treatment.
This
platform,
by
offering
approach
nanophotonics
monitor
can
pave
way
new
applications
fundamental
biological
studies,
screening,
development
therapies.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(11)
Published: March 13, 2024
The
transmission
of
viral
diseases
is
highly
unstable
and
contagious.
As
the
carrier
virus
transmission,
cell
an
important
factor
to
explore
mechanism
disease.
However,
there
still
a
lack
effective
means
continuously
monitor
process
infection
in
cells,
no
rapid,
high-throughput
method
assess
status
infection.
On
basis
light
diffraction
fingerprint
we
applied
gray
co-occurrence
matrix,
set
two
parameters
effectively
distinguish
time
visualized
cells
high
throughput.
We
provide
efficient
nondestructive
testing
for
selection
excellent
livestock
poultry
breeds
at
cellular
level.
Meanwhile,
our
work
provides
detection
methods
recessive
human-to-human,
animal-to-animal,
zoonotic
inhibit
block
their
further
development.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(2), P. e0317426 - e0317426
Published: Feb. 21, 2025
Terahertz
(THz)
waves,
positioned
between
microwave
and
infrared
in
the
electromagnetic
spectrum,
have
promising
applications
medical
imaging
biomedicine.
In
this
study,
terahertz
irradiation
at
2.52
THz
(100
mW/cm
2
)
did
not
alter
proliferation
of
human
umbilical
vein
endothelial
cells
(HUVECs),
but
significantly
enhanced
their
angiogenic
capacity.
This
enhancement
was
accompanied
by
increased
levels
angiogenesis-related
proteins
such
as
VEGF
culture
supernatant.
ATAC
sequencing
RNA
revealed
a
significant
increase
expression
cytoskeleton-associated
genes,
including
PDXP
SH3BP1,
post-irradiation.
Additionally,
intracellular
calcium
concentration,
closely
linked
to
angiogenesis,
markedly
following
exposure.
However,
diltiazem
mitigated
capacity
induced
irradiation.
conclusion,
promotes
angiogenesis
HUVECs,
partly
activating
signaling
pathway
through
fluxes.
Advanced
biosensors
must
exhibit
high
sensitivity,
reliability,
and
convenience,
making
them
suitable
for
detecting
trace
samples
in
biological
or
medical
applications.
Currently,
biometric
identification
is
the
predominant
method
clinical
practice,
but
it
complex
time-consuming.
In
this
study,
we
propose
an
optical
metasurface
utilizing
Fano
resonance
effect,
which
exhibits
a
sharp
with
transmittance
of
32%
at
0.65
THz.
The
dip
has
narrow
bandwidth
0.07
THz
