ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22257 - 22274
Published: Aug. 9, 2024
Iron metabolism has emerged as a promising target for cancer therapy; however, the innate metabolic compensatory capacity of cells significantly limits effectiveness iron therapy. Herein, bioactive gallium sulfide nanodots (GaS
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 9, 2025
Metals have been used throughout history to manage disease. With the rising incidence of antibiotic-resistant bacterial strains, metal-based antimicrobials (MBAs) re-emerged as an alternative combat infections. Gallium nitrate has shown promising efficacy against several pathogens. Although its main toxicity mechanisms focused on oxidative stress and "trojan horse" iron mimetic strategy, there are still many knowledge gaps in full-systems response elicited counteract toxic effects, especially non-acute models that evaluate longer exposure times. In this study, we explore transcriptomic profile Escherichia coli K12 BW25113 when challenged grow planktonically for 10 h presence a sublethal inhibitory concentration gallium nitrate. 581 genes were significantly up-regulated, 791 down-regulated. Some affected biological systems identified our analysis include homeostasis, sulfate metabolism, nitrosative response, cysteine biosynthesis, anaerobic respiration, toxin-antitoxin interactions, DNA repair. Altogether, work provides valuable snapshot how E. acclimates MBA expands current sensitivity tolerance. This is significant step understanding bacteria can adjust their physiology coexist with concentrations metals.
Language: Английский
Citations
1
Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 101018 - 101018
Published: Jan. 10, 2025
Nitric oxide (NO) modulates several cancer-related physiological processes and has advanced the development of green methods for cancer treatment integrated platforms combination or synergistic therapies. Although a nanoengineering strategy been proposed to overcome deficiencies NO gas small donor molecules, such as short half-life, lipophilicity, non-selectivity, poor stability, it remains challenging prepare nanomedicines with simple composition, multiple functions enhanced therapeutic efficacy. Herein, we build liquid metal nanodroplet (LMND)-based nanogenerator (LMND@HSG) that is stabilized by bioreducible guanylated hyperbranched poly(amido amine) (HSG) ligand. Mechanically, tumor microenvironment specifically triggers cascade process glutathione elimination, reactive oxygen species (ROS) generation, release. According actual demand, ROS concentrations could be readily controlled tuning LMND HSG feed amounts. Along intrinsic anticancer property (ROS-mediated apoptosis anti-angiogenesis), LMND@HSG administration further enhance growth suppression compared alone. From this study, leveraging therapy provides more possibilities prospect LMND-based nanomedicines.
Language: Английский
Citations
1
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161120 - 161120
Published: Feb. 1, 2025
Language: Английский
Citations
1
Advanced Science, Journal Year: 2023, Volume and Issue: 11(37)
Published: Dec. 25, 2023
Abstract Phase change materials that can absorb or release large amounts of heat during phase transition, play a critical role in many important processes, including dissipation, thermal energy storage, and solar utilization. In general, are usually encapsulated passive modules to provide assurance for management. The shape mechanical changes these greatly ignored. An emerging class materials, liquid metals (LMs) have attracted significant interest beyond management, transformable robots, flexible electronics, soft actuators, biomedicine. Interestingly, the melting point LM is highly tunable around body temperature, allowing it experience considerable stiffness when interacting with human organisms solid–liquid change, which brings about novel phenomena, applied technologies, therapeutic methods, such as destruction tumors, neural electrode implantation technique, embolization therapy. This review focuses on technology, regulation, application process along diverse facilitate biomedical applications based influences versatile regulation strategies. Typical will also be categorized summarized. Lastly, advantages challenges using unique reversible biomedicine discussed.
Language: Английский
Citations
19
National Science Review, Journal Year: 2023, Volume and Issue: 11(2)
Published: Nov. 29, 2023
ABSTRACT Until now, significant healthcare challenges and growing urgent clinical requirements remain incompletely addressed by presently available biomedical materials. This is due to their inadequate mechanical compatibility, suboptimal physical chemical properties, susceptibility immune rejection, concerns about long-term biological safety. As an alternative, liquid metal (LM) opens up a promising class of biomaterials with unique advantages like biocompatibility, flexibility, excellent electrical conductivity, ease functionalization. However, despite the successful explorations LM in fields, widespread translations applications LM-based medical products limited. article summarizes current status future prospects biomaterials, interprets healthcare, imaging, bone repair, nerve interface, tumor therapy, etc. Opportunities translate materials into medicine obstacles encountered practices are discussed. Following that, we outline blueprint for clinics, emphasizing potential making new-generation artificial organs. Last, core translation, including bio-safety, material stability, ethical also Overall, progress, translational bottlenecks, perspectives signify immense drive breakthroughs thus open novel avenues upcoming practices.
Language: Английский
Citations
17
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 329, P. 103183 - 103183
Published: May 16, 2024
Gallium-based liquid metals (GaLMs) have garnered monumental attention from the scientific community due to their diverse actuation characteristics. These possess remarkable characteristics, including high surface tension, excellent electrical and thermal conductivity, phase transformation behaviour, minimal viscosity vapour pressure, lack of toxicity, biocompatibility. In addition, GaLMs melting points that are either lower or near room temperature, making them incredibly beneficial when compared solid since they can be easily deformed. Thus, there has been significant progress in developing multifunctional devices using GaLMs, bio-devices, flexible self-healing circuits, actuators. Despite numerous reports on these (LMs), is an urgent need for consolidated coherent literature regarding principles linked targeted application. This will ensure reader gets flavour physics behind mechanism how it utilized fields. Moreover, scattered literature, thus, primary motive this review provide a one-stop solution associated dynamics while directing readers specialized literature. addressing issue, we thoroughly examine present detailed account mechanisms highlighting science them. We also discuss various morphologies crucial physical characteristics which decide Furthermore, delve into commonly held beliefs about such as toxicity antibacterial properties, offer more accurate understanding. Finally, explored several key unanswered aspects LM should future research. The core strength lies its simplistic approach offering starting point researchers venturing innovative field, make use existing develop comprehensive
Language: Английский
Citations
8
Science Advances, Journal Year: 2024, Volume and Issue: 10(42)
Published: Oct. 18, 2024
Wearable haptics serve as an enhanced media to connect humans and VR/robots. The inevitable sweating issue in all wearables creates a bottleneck for wearable haptics, the sweat/moisture accumulated skin/device interface can substantially affect feedback accuracy, comfortability, create hygienic problems. Nowadays, typically gain performance at cost of sacrificing breathability, comfort, biocompatibility. Here, we developed fully integrated breathable haptic textile (FIBHT) solve these trade-off issues, where FIBHT exhibits high-level integration 128 pixels over palm, great stretchability 400%, superior permeability 657 g/m 2 /day (moisture) 40 mm/s (air). It is stand-alone system totally composed stretchable, breathable, bioadhesive materials, which empowers it with precise, sweating/movement-insensitive dynamic feedback, makes powerful virtual touching broad scenarios.
Language: Английский
Citations
7
Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 59, P. 104992 - 104992
Published: Feb. 14, 2024
Language: Английский
Citations
6
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(31)
Published: Oct. 11, 2023
Abstract Liquid metals, particularly non‐toxic gallium‐based alloys, have emerged as promising materials for future soft electronics due to their unique properties, including fluidity, excellent electrical and thermal conductivities, surface reactivity. They demonstrate adaptability, responsivity, self‐healing abilities, offering a platform innovative electronic devices. Embodied in droplet form factor, liquid metal droplets (LMDs) combine the traits of metals with advantages miniaturized structures, high tension, area, mobility, functionalization. This review discusses inherent properties LMDs, which driven substantial research interest across various fields, such sensors, robotics, circuits, energy harvesters, drug delivery, microfluidics systems, among others. Effective fabrication processing techniques are detailed illustrating role applications previously challenging conventional materials, reconfigurable, self‐healing, transient electronics. Existing challenges directions this growing field discussed. extensive seeks further understanding LMDs potential, roadmap journey from niche key material
Language: Английский
Citations
16
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 479, P. 147894 - 147894
Published: Dec. 8, 2023
Because of their high electrical conductivity, fluidic deformability, self-healing properties, and the possibility recycling, Ga-based liquid metal alloys like eutectic gallium indium (EGaIn) have tremendous potential as electrodes for stretchable energy storage devices. However, EGaIn droplets could never be used in thin-film supercapacitors (SCs) at desired micro/nano scale, because they rapidly coalesce into bulk when contacting acidic/alkaline electrolytes. Here, we show that coating with only 0.08 wt% reduced graphene oxide (GO) nanosheets tremendously improves chemical stability. We fabricated binder-free GO-coated nanocomposite excellent stability a strong alkaline electrolyte. demonstrated symmetric soft-matter pseudo-SC areal capacitances 1200mF/[email protected] mA/cm2 220mF/cm2@1mA/cm2, which is > 10 × compared to previous SCs based on EGaIn. This SC retains 98.4 % initial capacitance after 4000 electrochemical cycles exhibits comparable self-discharge rates state-of-the-art flexible pseudo-SCs. Surprisingly, applying mechanical strain results improved capacitance. demonstrate rapid, laser-based fabrication wirelessly chargeable elastic film an integrated harvesting antenna energy-storage can wearable biomonitoring patches, e-textiles. Finally, recovery metals from disposed through electrowinning technique.
Language: Английский
Citations
14