Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single‐Component Organic Phototherapeutic Agents

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Photodynamic therapy (PDT) and photothermal (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic nononcologic diseases. Single‐component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, enhanced reproducibility. Nonetheless, how further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies performance PDT PTT by optimizing structural design SCOPAs. These encompass augmenting reactive oxygen species (ROS) generation, mitigating dependence, elevating light absorption capacity, broadening region, enhancing conversion efficiency (PCE). Additionally, this also underscores ideal for developing with balanced PTT. Furthermore, synergies are highlighted between other modalities such ferroptosis, gas therapy, chemotherapy, immunotherapy. By providing comprehensive analysis these strategies, aspires serve valuable resource clinicians researchers, facilitating wider application advancement SCOPAs‐mediated

Language: Английский

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Triphenylamine‐Substituted Nile Red Derivatives with Efficient Reactive Oxygen Species Generation for Robust and Broad‐Spectrum Antimicrobial Photodynamic Therapy and Abscess Wound Healing

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Infections caused by drug‐resistant bacteria represent a major contributor to high mortality rates, underscoring the urgent need for effective non‐antibiotic drugs and alternative therapies. Antimicrobial photodynamic therapy (aPDT) emerges as an innovative treatment due its minimal drug resistance. Herein, series of Nile Red derivatives is synthesized donor engineering strategy. Notably, NTPA featuring triphenylamine (TPA) electron‐donating group, exhibited highest production reactive oxygen species (ROS). The enhanced electron donating‐accepting (D‐A) property effectively reduced energy gap between S 1 T (ΔE S‐T ), facilitating intersystem crossing (ISC) with larger spin‐orbit coupling (SOC) constant. Furthermore, twisted conformation profoundly suppressed quenching ROS. As expected, over 470‐fold increase in ROS observed, predominantly comprising type‐I nanoparticles (NPs) exceptional vitro killing ability against various bacteria, inhibition efficiency even reaching 99.9%. In methicillin‐resistant staphylococcus aureus (MRSA)‐induced abscess model, NPs facilitated complete wound healing within just 8 days following single administration irradiation, highlighting their bactericidal wound‐healing promotion capabilities. Overall, this work inspired construction efficient Red‐based photosensitizers (PSs) development new broad‐spectrum aPDT method treatment.

Language: Английский

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Glutathione‐Driven Disassembly of Planar Organic Phototherapeutic Agents to Enhance Photodynamic‐Photothermal Therapy Performance for Nasopharyngeal Carcinoma

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

The self-assembly of hydrophobic organic phototherapeutic agents (OPTAs) with expansive planar structures into nanoparticles (NPs) represents a pivotal strategy to bolster their biocompatibility. However, the tight molecular packing within these NPs significantly influences generation reactive oxygen species (ROS) and photothermal conversion efficiency (PCE), posing substantial hurdle elevating efficacy photodynamic therapy (PDT) (PTT) for such NPs. In this article, three OPTAs by donor engineering are synthesized. Notably, 4,8-Bis (5-phenylthiophen-2-yl)-6-(2-ethylhexyl)-[1,2,5] thiadiazole [3,4-F] benzotriazole (BTBT), which incorporates benzene ring as donor, exhibits highest ROS optimal capability. To further augment overall phototheranostic potential BTBT NPs, glutathione (GSH)-driven disassembly is employed. This not only alleviates aggregation-caused quenching (ACQ) effect on but also facilitates enhanced free rotation. As result, production sees tenfold increase, temperature rises 8.3 °C, achieving PCE 77.03%. summary, versatile proposed that concurrently enhances performance both PDT PTT in OPTAs, while advancing state-of-the-art nasopharyngeal carcinoma (NPC) treatment.

Language: Английский

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Pyrrolopyrrole Cyanine J-Aggregates with Amplified Superoxide Radical Generation, GSH Depletion, and Photothermal Action for Hypoxic Cancer Phototherapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The elevated glutathione (GSH) level and hypoxia in tumor cells are two key obstacles to realizing the high performance of phototherapy. Herein, electron-donating rotors introduced wings electron-withdrawing pyrrolopyrrole cyanine (PPCy) form donor-acceptor-donor structure

Language: Английский

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Donor Modulation Brings All-In-One Phototheranostics for NIR-II Imaging-Guided Type-I Photodynamic/Photothermal Synergistic Cancer Therapy

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel all-in-one phototheranostics OTAB was synthesized by modifying the donor and regulating band gap for NIR-II imaging-guided synergistic type-I PDT/PTT therapy.

Language: Английский

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A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(11), P. 2831 - 2840

Published: Jan. 1, 2024

A chemicobiology toolbox for type I and II photodynamic therapy.

Language: Английский

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Multifunctional ZnO@DOX/ICG-LMHP Nanoparticles for Synergistic Multimodal Antitumor Activity

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(2), P. 35 - 35

Published: Jan. 30, 2024

Multifunctional nanoparticles are of significant importance for synergistic multimodal antitumor activity. Herein, zinc oxide (ZnO) was used as pH-sensitive loading the chemotherapy agent doxorubicin (DOX) and photosensitizer indocyanine green (ICG), biocompatible low-molecular-weight heparin (LMHP) gatekeepers photothermal therapy/photodynamic therapy/chemotherapy/immunotherapy. ZnO decomposed into cytotoxic Zn2+ ions, leading to a tumor-specific release ICG DOX. simultaneously produced oxygen (O2) reactive species (ROS) photodynamic therapy (PDT). The released under laser irradiation ROS PDT raised tumor temperature (PTT). DOX directly caused cell death chemotherapy. Both also induced immunogenic (ICD) immunotherapy. in vivo vitro results presented superior inhibition progression, metastasis recurrence. Therefore, this study could provide an efficient approach designing multifunctional therapy.

Language: Английский

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Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry and π-bridge effect design philosophy

Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is appealing yet challenging task. In this study, we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry the design philosophy π -bridge effect. Through systematic comparative analysis their fluorescence properties, water solubility, molecular conformation, electrostatic potential, revealed fundamental principles governing optical behavior biological selectivity these probes. Notably, probe TPhIQ-CNTh demonstrated extended near-infrared region, significant aggregation-induced emission (AIE) effect, ability to distinguish tumor cells from normal cells. Moreover, it efficiently generated reactive oxygen species (ROS) specifically labeled lipid droplets, enabling precise staining killing cancer This study presents practical strategy for designing treatments integrate efficient imaging-guided photodynamic (PDT) harnessing unique properties AIE materials.

Language: Английский

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Diketopyrrolopyrrole-Based Nanoparticles with Near-Infrared Absorption for Tumor Photothermal Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: 8(4), P. 2054 - 2061

Published: Jan. 17, 2025

Diketopyrrolopyrrole (DPP) is now widely used in the phototherapy of tumors, but most reported DPP molecules have no absorption near-infrared (NIR) region. In this study, 3 derivatives with donor–acceptor–donor (D-A-D) structures were designed and synthesized, which named OODPP, OSDPP, SSDPP according to number thione groups. Their spectra are gradually red-shifted an increase However, after preparation nanoparticles (NPs), OSDPP NPs show maximum red shift peak at 786 nm excellent photothermal performance under NIR laser irradiation. addition, could more effectively inhibit tumor growth Therefore, work provides a feasible method for design DPP-based phototherapeutic agents therapy.

Language: Английский

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Rational design of AIEgens through π-bridge engineering for dual-modal photodynamic and photothermal therapy

Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 119, P. 118081 - 118081

Published: Jan. 23, 2025

Language: Английский

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