CpG-mediated TLR9 signalling enhances the efficacy of the OprF/PcrV DNA vaccine with cGAS-STING-activating properties DOI Creative Commons
Linxia Tian,

Hongxi He,

Han Liu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Abstract Background Pseudomonas aeruginosa (PA) infection poses a major global threat to health care. DNA vaccines, which induce humoral and cellular immunity, are promising for preventing treating PA infection. However, the low immunogenicity of vaccines has limited its clinical application. Therefore, this study seeks explore whether OprF/PcrV vaccine can activate cGAS-STING pathway boost by combining CpG adjuvant presumably activates TLR9 pathway. Results We found that DNA-OprF/PcrV + could pathways, innate immune responses, stimulate BMDC maturation. In addition, in vivo data revealed strong antigen-specific responses protect mice with pneumonia from PAO1 reducing bacterial burden lungs lung inflammation. Finally, showed reliable biosafety. Conclusion This conclusively demonstrated vaccine, when combined CpG, effectively stimulated response through subsequently enhancing adaptive response. synergistic combination not only triggers robust immunity but also enhances indicating may serve as option against both intracellularly extracellularly.

Language: Английский

Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment DOI Creative Commons

Yunheng Liu,

Lei Si, Yuxuan Jiang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 705 - 721

Published: Jan. 1, 2025

The metabolic activity of tumor cells leads to the acidification surrounding microenvironment, which provides new strategies for application nanotechnology in cancer therapy.Researchers have developed various types pH-responsive nanomaterials based on acidic microenvironment.This review an in-depth discussion design mechanisms, drug-loading strategies, and pathways microenvironment-responsive nanodrug delivery systems.These materials trigger drug release upon reaching enhancing therapeutic targeting reducing toxicity healthy cells.pH-responsive include organic nanomaterials, inorganic composite nanomaterials.Additionally, this outlines prospects, challenges aiming promote development clinical translation field.

Language: Английский

Citations

3
Exploring the immuno-nano nexus: A paradigm shift in tumor vaccines DOI Open Access
Yuanyuan Li, Yuxing Xu,

Wenwen Su

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117897 - 117897

Published: Feb. 7, 2025

Language: Английский

Citations

1
Robust Cu2+-Modified Black Phosphorus Nanoplatform for Enhanced Drug Delivery and Synergistic Multimodal Tumor Therapy via Metal Ion-Assisted π–π Interactions DOI
Kai Ling,

Jianlan Bu,

Weijie Huang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The application of 2D nanomaterials for drug delivery via π-π interactions has been extensively investigated. However, these often lack robustness in the presence blood proteins due to competitive binding proteins, which results from strong π-π-stacking with aromatic protein residues. This can lead premature release and diminished therapeutic efficacy. To address this challenge, we developed a robust delivery/therapeutic biomimetic nanoplatform that enhances adsorption affinity targeted efficiency chemotherapeutic doxorubicin (DOX) by utilizing Cu2+-modified black phosphorus nanosheets (BP@Cu2+) through metal ion-assisted interactions. synergistic between π-electrons BP DOX, mediated Cu2+ coordination, form stable sandwiched π-cation-π stacking complex (BP@Cu2+/DOX). metal-ion-bridged architecture significantly DOX loading capacity minimizes serum. In acidic tumor microenvironment, interaction is disrupted, enabling controlled both ions. Furthermore, encapsulation within cell membranes targeting, resulting (BP@Cu2+/DOX-CMs). Combined near-infrared laser irradiation, achieves multimodal therapy integrating phototherapy, chemotherapy, chemodynamic therapy, cuproptosis enhance antitumor study highlights potential development advanced nanoplatforms, thereby paving way innovative biomedical applications conventional nanomaterials.

Language: Английский

Citations

1
Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment DOI
Yutang Li, Yandong Wang, Zhao Li

et al.

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(18), P. 4275 - 4310

Published: Jan. 1, 2024

This comprehensive review systematically summarizes the intrinsic mechanism of different metal ion (such as Fe 3+ /Fe 2+ , Cu /Cu + Ca Zn Mn Na /K and Mg )-mediated interference therapies their research progress in cancer treatment.

Language: Английский

Citations

7
2D nanomaterials-based delivery systems and their potentials in anticancer synergistic photo-immunotherapy DOI

Yankun Luo,

Ming Chen, Ting Zhang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114074 - 114074

Published: July 4, 2024

Language: Английский

Citations

5
Bifunctional cascaded single-atom nanozymes for enhanced photodynamic immunotherapy through dual-depressing PD-L1 and regulating hypoxia DOI
Jiansen Li, Chen Cao, Xinlu Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123106 - 123106

Published: Jan. 11, 2025

Language: Английский

Citations

0
HIFU postoperative hypoxia enables metal-organic frameworks amplifying banoxantrone and STING activation for enhanced immunotherapy DOI
Ying‐Lin Zhou,

Xinchang Huang,

Dezhou Wu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159704 - 159704

Published: Jan. 1, 2025

Language: Английский

Citations

0
Spatially Targeted Triple Amplification of Oxidative Stress for Enhanced Tumor Therapy via Effective Modulation of Metal Ion Valence States DOI

Jing Yu,

Chen Wang,

Fan Zhao

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Metal coordination polymer nanoparticles for cancer therapy DOI Creative Commons
Zhengzheng Zhang, Isra Rana, Jutaek Nam

et al.

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)

Published: April 10, 2025

Metal ions are essential elements in biological processes and immune homeostasis. They can regulate cancer cell death through multiple distinct molecular pathways stimulate cells implicated antitumor responses, suggesting opportunities to design novel metal ion-based therapies. However, their small size high charge density result poor target uptake, uncontrolled biodistribution, rapid clearance from the body, reducing therapeutic efficacy increasing potential off-target toxicity. coordination polymer nanoparticles (MCP NPs) nanoscale networks composed of organic ligands linked via noncovalent interactions. MCP NPs offer a promising nanoplatform for reshaping into more drug-like formulations, improving vivo pharmacological performance index therapy applications. This review provides comprehensive overview inherent functions therapy, showcasing examples NP systems designed preclinical applications where drug delivery principles play critical role enhancing outcomes. versatile ion engineering approaches using selected ions, various ligands, functional payloads, enabling on-demand nano-drug designs that significantly improve reduce side effects effective therapy.

Language: Английский

Citations

0
Endogenous Nanoplatforms for Tumor Photoimmunotherapy: Hypoxia Modulation and STING Pathway Activation DOI

Yongqing Yang,

Ni Shao,

Qiao Luo

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0