Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 14, 2024
Language: Английский
Nano Today, Journal Year: 2024, Volume and Issue: 58, P. 102448 - 102448
Published: Aug. 23, 2024
Language: Английский
Citations
2
Small Science, Journal Year: 2024, Volume and Issue: unknown
Published: June 9, 2024
The highly efficient peroxidase‐like activity of platinum nanozymes (3–20 nm size) is exploited within the complex cellular environment to catalyze oxidation DAB substrate, producing an electron‐dense signal around nanozyme surface, upon osmium staining. It proved that such amplification can achieve a catalytic enhancement up 10‐fold, enabling quick detection Pt particles (even 3 by transmission electron microscopy (TEM) also at low magnification and across wide fields view in intricate intracellular milieu. developed procedure ideally suited overcome standard strategies currently used TEM analysis, as gold or silver enhancements. Furthermore, versatility Pt‐nanozyme probes imaging demonstrated immuno‐EM protein trafficking studies, showing their potential track subcellular localization target biomolecules both high magnifications. These results suggest use might represent paradigm shift conventional systems employed for analyses, offering enhanced capabilities.
Language: Английский
Citations
1
Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1579 - 1579
Published: July 16, 2024
This review article delves into the intricate roles of reactive oxygen species (ROS) in pathogenesis age-related macular degeneration (AMD). It presents a detailed analysis oxidative stress mechanisms that contribute to development and progression these diseases. The systematically explores dual nature ROS ocular physiology pathology, underscoring their essential cellular signaling detrimental effects when excess. In context AMD, focus is on impairment retinal pigment epithelium Bruch's membrane, culminating deterioration health. Central this evaluation various antioxidant strategies prevention management AMD. encompasses wide spectrum antioxidants, ranging from dietary nutrients like vitamins C E, lutein, zeaxanthin pharmacological agents with antioxidative properties. also addresses novel therapeutic approaches, including gene therapy nanotechnology-based delivery systems, aiming enhance defense tissues. concludes by synthesizing current research findings, clinical trial data, meta-analyses provide evidence-based recommendations. underscores need for further optimize therapies, considering individual patient factors disease stages. comprehensive thus serves as valuable resource clinicians, researchers, healthcare professionals ophthalmology, offering insights potential antioxidants mitigating burden
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 239 - 255
Published: Nov. 21, 2024
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138337 - 138337
Published: Dec. 5, 2024
Language: Английский
Citations
1
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: June 12, 2024
Abstract Topical eyedrop administration is identified as an ideal non‐invasive strategy for ocular drug delivery. However, multiple complex barriers greatly restrict their effectiveness in the treatment of posterior disease. Herein, a liposome‐based permeable eyedrops (pDrops) capable overcoming and achieving efficient delivery presented. pDrops have core‐shell structure which drugs are encapsulated inside liposome core with chitosan shell. This coating significantly enhances pDrops’ binding to mucin tears facilitates temporary opening tight junctions cornea/conjunctive epithelial cells, thereby prolonged preocular retention enhanced segment In this study, hydrophilic ganciclovir (GCV) hydrophobic curcumin (CUR) employed model drugs. Upon topical instillation, effectively overcome delivered GCV both rat rabbit eyes. Notably, CUR by demonstrates therapeutic efficacy light‐damaged retina mice. Considering that can deliver eye, it potentially become feasible platform various molecules improve efficiency diseases.
Language: Английский
Citations
0
Small, Journal Year: 2024, Volume and Issue: 20(43)
Published: June 26, 2024
Retinitis pigmentosa is the main cause of inherited human blindness and associated with dysfunctional photoreceptors (PRs). Compared traditional methods, optoelectronic stimulation can better preserve structural integrity genetic content retina. However, enhancing spatiotemporal accuracy challenging. Quantum dot-doped ZnIn
Language: Английский
Citations
0
Biophysics Reviews, Journal Year: 2024, Volume and Issue: 5(4)
Published: Nov. 5, 2024
Nanotechnology has demonstrated tremendous promise in the realm of ocular illnesses, with applications for disease detection and therapeutic interventions. The nanoscale features nanoparticles enable their precise interactions retinal tissues, allowing more efficient effective treatments. Because biological organs are compatible diverse nanomaterials, such as nanoparticles, nanowires, nanoscaffolds, hybrid nanostructures, usage biomedical applications, particularly increased. use nanotechnology medicine is advancing rapidly, recent advances nanomedicine-based diagnosis therapy techniques may provide considerable benefits addressing primary causes blindness related to illnesses. current state, prospects, challenges monitoring nanostructures or cells eye application regenerative ophthalmology have been discussed thoroughly reviewed. In this review, we build on our previously published review article 2021, where impact nano-biomaterials regeneration. However, extended focus incorporate discuss all diseases, a highlight diagnostic research studies.
Language: Английский
Citations
0
Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 264, P. 112794 - 112794
Published: Dec. 4, 2024
Language: Английский
Citations
0
Small Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 6, 2024
Nanozymes (NZs) are nanomaterials able to mimic natural enzymes, offering the advantages of better durability, wider range operational conditions, and easier functionalization. In addition, some NZs exhibit multiple enzyme‐like activities effective tandem/self‐cascade reactions. this context, metallic metal–oxide nanoparticles among most promising candidates for biomedical/biotechnological applications, thanks their efficient oxidoreductase activities. However, characterizing is challenging because experimental set‐up different assays strongly influence performances. Consequently, currently available literature provides limited understanding characteristics various NZs, especially in terms activity‐related performance, hindering optimal selection applicative potential. Here, leveraging on accurate characterization methodology, we report a direct comparison several (gold‐Au, platinum‐Pt, palladium‐Pd, ceria, iron oxide) possessing multi‐enzymatic Our main findings indicate that 1) PtNZs outperform other tested catalase‐like activity; 2) Pt PdNZs present superior superoxide dismutase‐like 3) peroxidase‐ oxidase‐like activity, best‐performing NZ substrate‐dependent; 4) competitive reactions multifunctional play key role specific AuNZs can be choice peroxidase/oxidase configurations; 5) more than metal‐oxide ones, but 6) ceria presents unique phosphatase‐like activity.
Language: Английский
Citations
0